ID
45996
Descripción
Principal Investigator: Stacey Gabriel, PhD, Broad Institute, Boston, MA, USA MeSH: Coronary Artery Disease https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000917 The Pakistan Risk of Myocardial Infarction (PROMIS) study is a retrospective multicenter case-control cohort study of individuals with and without coronary heart disease from Pakistan. Multiple biological samples have been collected from the participants including DNA, plasma, serum, and whole blood. The goal of the study is to recruit 20,000 cases and 20,000 controls of Pakistani descent. All exome sequencing was performed at the Broad Institute of Harvard and MIT; samples sequence capture was performed using either Agilent's SureSelect Human All Exon Kit v2 or Illumina's ICE capture reagent; and sequencing was performed on an Illumina HiSeq 2000 or 2500.
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Versiones (1)
- 14/4/24 14/4/24 - Madita Rudolph
Titular de derechos de autor
Stacey Gabriel, PhD, Broad Institute, Boston, MA, USA
Subido en
14 de abril de 2024
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs000917 MIGen_ExS: PROMIS
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent file contains subject IDs, consent group information, and affection status. Eligible cases were individuals age 30-80 who presented to the emergency department of a participating recruitment center in Pakistan with clinical symptoms consistent with a myocardial infarction (MI), ECG changes consistent with MI, elevated troponin levels consistent with MI, and no prior history of cardiovascular disease. Controls were individuals of Pakistani descent who did not have a self-reported history of cardiovascular disease.
- This subject sample mapping file contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype data table contains gender of participants.
- This sample attributes data table includes sample analyte type.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent file contains subject IDs, consent group information, and affection status. Eligible cases were individuals age 30-80 who presented to the emergency department of a participating recruitment center in Pakistan with clinical symptoms consistent with a myocardial infarction (MI), ECG changes consistent with MI, elevated troponin levels consistent with MI, and no prior history of cardiovascular disease. Controls were individuals of Pakistani descent who did not have a self-reported history of cardiovascular disease.
- This subject sample mapping file contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype data table contains gender of participants.
- This sample attributes data table includes sample analyte type.
C0680251 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,2])
C1706256 (UMLS CUI [2,1])
C0001779 (UMLS CUI [2,2])
C0205210 (UMLS CUI [2,3])
C1457887 (UMLS CUI [2,4])
C1623258 (UMLS CUI [2,5])
C0523953 (UMLS CUI [2,6])
C0332290 (UMLS CUI [2,7])
C0027051 (UMLS CUI [2,8])
C0332288 (UMLS CUI [2,9])
C0455539 (UMLS CUI [2,10])
C0009932 (UMLS CUI [3,1])
C0332288 (UMLS CUI [3,2])
C0007222 (UMLS CUI [3,3])
C2700446 (UMLS CUI [3,4])