ID
45981
Descrição
Principal Investigator: Francis McMahon, MD, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA MeSH: Bipolar Disorder,Psychotic Disorders,Depressive Disorder, Major https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000899 Bipolar affective disorder is a severe, heritable condition affecting about one percent of the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed.
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Versões (1)
- 02/04/2024 02/04/2024 - Madita Rudolph
Titular dos direitos
Francis McMahon, MD, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Transferido a
2 de abril de 2024
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs000899 NIMH Amish Mennonite Bipolar Genetics Study (AmBiGen)
This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This table also contains sample aliases.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject ID, consent information, and case control status of the subject for bipolar disorder.
- The subject pedigree table contains family ID, subject ID, mother ID, father ID, sex, monozygotic twin, and MZ twin ID.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This table also contains sample aliases.
- This subject phenotype table contains subject ID, sex, best estimate final diagnosis, participants with Amish ancestry or Mennonite ancestry.
- This sample attribute table contains sample ID, analyte type, histological type, tumor status, and name of the center where sequencing was conducted.
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This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This table also contains sample aliases.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject ID, consent information, and case control status of the subject for bipolar disorder.
- The subject pedigree table contains family ID, subject ID, mother ID, father ID, sex, monozygotic twin, and MZ twin ID.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This table also contains sample aliases.
- This subject phenotype table contains subject ID, sex, best estimate final diagnosis, participants with Amish ancestry or Mennonite ancestry.
- This sample attribute table contains sample ID, analyte type, histological type, tumor status, and name of the center where sequencing was conducted.
C0449416 (UMLS CUI [1,2])
C2347026 (UMLS CUI [1,3])
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,3])
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