ID
45976
Descrizione
Principal Investigator: Dan Roden, MD, Vanderbilt University Medical Center, Nashville, TN, USA MeSH: Acute Kidney Injury https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000894 The goal of this study was to identify genetic variants associated with risk for acute kidney injury (AKI) in patients being treated with vancomycin and genetic variants associated with variability in vancomycin pharmacokinetics. AKI is a common adverse drug event and known complication of vancomycin therapy. Known risk factors fail to accurately predict renal toxicity. Our hypothesis, that genetic variants modify the risk of AKI, was tested by performing genome-wide association and linear regression in 429 patients of European descent using the outcome of peak serum creatinine while on vancomycin. We also tested the hypothesis that genetic variants associate with vancomycin pharmacokinetics, using vancomycin trough levels and calculated renal elimination rate constant as outcomes.
collegamento
Keywords
versioni (1)
- 02/04/24 02/04/24 - Madita Rudolph
Titolare del copyright
Dan Roden, MD, Vanderbilt University Medical Center, Nashville, TN, USA
Caricato su
2 aprile 2024
DOI
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Licenza
Creative Commons BY 4.0
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dbGaP phs000894 Genome Wide Study of Vancomycin
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject - Consent - Affection Status Information (All participating subjects are cases - on Vancomycin therapy)
- Subject - Sample Mapping
- The dataset provides data of the quantitative outcome variable (i.e. highest serum creatinine levels measured in the first 2 weeks of intravenous vancomycin therapy, after at least three doses administered), and basic socio-demographic information (age, gender, race).
- Sample - Attribute Information
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject - Consent - Affection Status Information (All participating subjects are cases - on Vancomycin therapy)
- Subject - Sample Mapping
- The dataset provides data of the quantitative outcome variable (i.e. highest serum creatinine levels measured in the first 2 weeks of intravenous vancomycin therapy, after at least three doses administered), and basic socio-demographic information (age, gender, race).
- Sample - Attribute Information
C0680251 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,2])
C0042313 (UMLS CUI [1,3])
C3174092 (UMLS CUI [1,4])
C0086749 (UMLS CUI [1,5])
C1301725 (UMLS CUI [1,6])
C0680251 (UMLS CUI [2,1])
C0001779 (UMLS CUI [2,2])
C0015031 (UMLS CUI [2,3])
C0034378 (UMLS CUI [2,4])