ID
45975
Description
Principal Investigator: Immaculata De Vivo, PhD, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA and Harvard TH Chan School of Public Health, Boston, MA, USA MeSH: Carcinoma, Endometrioid,Endometrial Neoplasms,Uterine Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000893 Endometrial cancer, the most common gynecological malignancy in the United States, has both an environmental and genetic component. To this end, we conducted a genome-wide association study to identify genes involved in endometrial cancer using studies from the NCI-supported Epidemiology of Endometrial Cancer Consortium (E2C2). For the discovery stage we included samples from 6 cohort and 7 case control studies through 2007. The total number of cases genotyped were 2,307, white women of European descent, and 2,307 matched controls using the Illumina HumanOmniExpress platform. We conducted the replication using the Infinium HumanExome BeadChip, which successfully genotyped 177,139 variants in 1055 cases and 1778 controls from four ethnically diverse studies that are part of the Epidemiology of Endometrial Cancer Consortium (E2C2). The overall goal is to determine whether certain genotypes are predictive of future endometrial cancer risk, and whether the genotypes interact with established endometrial risk factors.
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Keywords
Versions (1)
- 4/2/24 4/2/24 - Madita Rudolph
Copyright Holder
Immaculata De Vivo, PhD, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA and Harvard TH Chan School of Public Health, Boston, MA, USA
Uploaded on
April 2, 2024
DOI
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License
Creative Commons BY 4.0
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dbGaP phs000893 Genome-Wide Association Study of Endometrial Cancer in E2C2
Subject ID, study for which samples were generated, and consent group of participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, study for which samples were generated, and consent group of participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- Subject ID, sample ID, and sample use variable obtained from participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- Subject ID, disease status, age at diagnosis, study from which samples were generated, endometrial cancer subtype, and eigenvector 1 - 10 of participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- Subject ID, disease status, age at diagnosis, and principal component 1-4 of participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- Sample ID, body site, analyte type, and tumor status of samples obtained from participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
Similar models
Subject ID, study for which samples were generated, and consent group of participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, study for which samples were generated, and consent group of participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- Subject ID, sample ID, and sample use variable obtained from participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- Subject ID, disease status, age at diagnosis, study from which samples were generated, endometrial cancer subtype, and eigenvector 1 - 10 of participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- Subject ID, disease status, age at diagnosis, and principal component 1-4 of participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
- Sample ID, body site, analyte type, and tumor status of samples obtained from participants with or without endometrial cancer and involved in the "Genome-Wide Association Study of Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)" project.
C0441833 (UMLS CUI [1,2])
C0242481 (UMLS CUI [1,2])
C0242481 (UMLS CUI [1,2])
C1285573 (UMLS CUI [1,2])