ID
45964
Description
Principal Investigator: David Wheeler, Baylor College of Medicine, Human Genome Sequencing Center, Houston, TX, USA MeSH: Carcinoma, Neuroendocrine,Pancreatic islet cell tumors,Neuroendocrine tumors https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000871 Pancreatic neuroendocrine tumors (PNETs), often referred to as "islet cell tumors", are neuroendocrine neoplasms that arise from cells of the endocrine and nervous system within the pancreas. These rare tumors which originate from the pancreatic islet are divided into many categories and are often classified by the hormone most strongly secreted. With the collaboration of the Elkins Pancreatic Center, the Human Genome Sequencing Center (HGSC) at Baylor College of Medicine had access to approximately 30 untreated tumor specimens and matched normal blood samples. Since the onset and progression of cancer is driven by extensive mutation of the genome, we are combining enrichment of exonic DNA with next generation sequencing to detect and characterize the somatic mutation profile of patients with pancreatic neuroendocrine cancer. This work was done at the Human Genome Sequencing Center (HGSC) in collaboration with the Elkins Pancreatic Center at Baylor College of Medicine in Houston, TX and was supported by grant number 5U54HG003273 from National Human Genome Research Institute (NHGRI).
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- 3/26/24 3/26/24 - Madita Rudolph
Copyright Holder
David Wheeler, Baylor College of Medicine, Human Genome Sequencing Center, Houston, TX, USA
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March 26, 2024
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License
Creative Commons BY 4.0
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dbGaP phs000871 Whole Exome Sequencing of Pancreatic Neuroendocrine Tumors
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- pht004568.v1.p1
- Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with pancreatic neuroendocrine tumors and involved in the "Whole Exome Sequencing of Pancreatic Neuroendocrine Tumors at The Human Genome Sequencing Center, Baylor College of Medicine (HGSC-BCM)" project.
- Subject ID, age, sex, race, subject history of tobacco use, amount of subject smoked, subject alcohol usage, status of Diabetes Mellitus, BMI, family history of malignancy, type of malignancy in family, follow up period after surgery of participants with pancreatic neuroendocrine tumors and involved in the "Whole Exome Sequencing of Pancreatic Neuroendocrine Tumors at The Human Genome Sequencing Center, Baylor College of Medicine (HGSC-BCM)" project.
- Sample ID, tumor status of sample, histologic type of sample, location of tumor within of pancreas, tumor stage [pT, pN], presence of vascular invasion, presence of perineural growth, and analyte type of participants with pancreatic neuroendocrine tumors and involved in the "Whole Exome Sequencing of Pancreatic Neuroendocrine Tumors at The Human Genome Sequencing Center, Baylor College of Medicine (HGSC-BCM)" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- pht004568.v1.p1
- Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with pancreatic neuroendocrine tumors and involved in the "Whole Exome Sequencing of Pancreatic Neuroendocrine Tumors at The Human Genome Sequencing Center, Baylor College of Medicine (HGSC-BCM)" project.
- Subject ID, age, sex, race, subject history of tobacco use, amount of subject smoked, subject alcohol usage, status of Diabetes Mellitus, BMI, family history of malignancy, type of malignancy in family, follow up period after surgery of participants with pancreatic neuroendocrine tumors and involved in the "Whole Exome Sequencing of Pancreatic Neuroendocrine Tumors at The Human Genome Sequencing Center, Baylor College of Medicine (HGSC-BCM)" project.
- Sample ID, tumor status of sample, histologic type of sample, location of tumor within of pancreas, tumor stage [pT, pN], presence of vascular invasion, presence of perineural growth, and analyte type of participants with pancreatic neuroendocrine tumors and involved in the "Whole Exome Sequencing of Pancreatic Neuroendocrine Tumors at The Human Genome Sequencing Center, Baylor College of Medicine (HGSC-BCM)" project.
C0680251 (UMLS CUI [1,2])
C0206695 (UMLS CUI [1,2])
C0332155 (UMLS CUI [1,3])