ID
45961
Description
Principal Investigator: Thomas Vaughan, MD, MPH, Fred Hutchinson Cancer Research Center, Seattle, WA, USA MeSH: Esophageal Neoplasms,Barrett Esophagus https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000869 BEAGESS is a genome-wide association study (GWAS) which takes advantage of the extensive data collected by investigators in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON, http://beacon.tlvnet.net), representing many of the high-quality population-based and other epidemiologic studies of BE and EA in the world. The overall goal of our research is to evaluate the influence of genetic susceptibility on risk of EA and its main precancerous condition, BE. The primary aims of the study are to identify tagSNPs most strongly associated with risk of esophageal adenocarcinoma (EA) and Barrett's esophagus (BE). In the secondary aims we will evaluate the extent to which the most significant associations vary according to key environmental and host factors for these conditions, including gender, obesity and cigarette smoking. These results will guide additional exploratory analyses examining ways in which individual SNP results might be aggregated to shed light in the importance of specific pathways relevant to the etiology of BE and EA, and to identify possible epistatic effects.
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Versions (1)
- 3/16/24 3/16/24 - Madita Rudolph
Copyright Holder
Thomas Vaughan, MD, MPH, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Uploaded on
March 16, 2024
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License
Creative Commons BY 4.0
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dbGaP phs000869 Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)
Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- StudyEvent: SEV1
- Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- Family ID, subject ID, mother ID, father ID, and sex of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- Subject ID, sex, age in 5 year categories, race, BMI, cigarette smoking status, pack year of smoking, continent of study participants, and analysis of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- Sample ID, superfamily, subject type, body site where sample was collected, tumor status, histological type of sample, and genotyping center of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
Similar models
Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- StudyEvent: SEV1
- Subject ID, consent group, subject source, source subject ID, and affection status of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- Family ID, subject ID, mother ID, father ID, and sex of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- Subject ID, sex, age in 5 year categories, race, BMI, cigarette smoking status, pack year of smoking, continent of study participants, and analysis of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
- Sample ID, superfamily, subject type, body site where sample was collected, tumor status, histological type of sample, and genotyping center of participants with or without Barrett's and esophageal adenocarcinoma and involved in the "Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)" project.
C0441833 (UMLS CUI [1,2])
C0549184 (UMLS CUI [1,2])
C0009797 (UMLS CUI [1,3])
C0205257 (UMLS CUI [1,4])
C2700399 (UMLS CUI [1,5])
C0030761 (UMLS CUI [1,6])
C5418626 (UMLS CUI [2,1])
C0549184 (UMLS CUI [2,2])
C0009797 (UMLS CUI [2,3])
C0205257 (UMLS CUI [2,4])
C2700399 (UMLS CUI [2,5])
C0017431 (UMLS CUI [2,6])
C4553389 (UMLS CUI [2,7])
C0242481 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,2])
C0681850 (UMLS CUI [1,3])
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,3])