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ID

45960

Beschreibung

Principal Investigator: Javed Khan, National Institutes of Health, Bethesda, MD, USA MeSH: Neuroblastoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000868 Neuroblastoma is the most common extra-cranial solid tumor in children. It represents 8% to 10% of all childhood cancers. Stage 4 Neuroblastoma is characterized by its clinical heterogeneous outcome. The special category, stage 4S tumors (2-5% of all NB) are chemo-sensitive, and the patients show spontaneous regression. On the other hand, MYCN amplification (25-30% of all NB) is associated with poor outcome of neuroblastoma, thus we further categorize stage 4 neuroblastoma into MYCN non-amplified and MYCN amplified group. Here we use transcriptome sequencing to characterize the transcriptome in 29 stage 4 Neuroblastoma samples.

Link

dbGaP study=phs000868

Stichworte

  1. 16.03.24 16.03.24 - Madita Rudolph
Rechteinhaber

Javed Khan, National Institutes of Health, Bethesda, MD, USA

Hochgeladen am

16. März 2024

DOI

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Lizenz

Creative Commons BY 4.0

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    dbGaP phs000868 Transcriptome Sequencing of Pediatric Neuroblastoma

    This sample attributes table includes sample IDs, analyte type, tumor status, histological type, metastatic status, tumor stage and sequencing center.

    pht004590
    Beschreibung

    pht004590

    Alias
    UMLS CUI [1,1]
    C3846158 (Other Coding)
    LOINC
    LA4728-7
    De-identified Sample ID
    Beschreibung

    SAMPLE_ID

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C4684638 (De-identified Information)
    UMLS CUI [1,2]
    C1299222 (Sample identification number)
    SNOMED
    372274003
    Analyte Type
    Beschreibung

    ANALYTE_TYPE

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C4744818 (Analyte Type)
    Tumor status
    Beschreibung

    IS_TUMOR

    Datentyp

    text

    Alias
    UMLS CUI [1,1]
    C0475752 (Tumor status)
    SNOMED
    277058005
    Cell or tissue type or subtype of sample
    Beschreibung

    HISTOLOGICAL_TYPE

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C2347026 (Biospecimen)
    UMLS CUI [1,2]
    C0007634 (Cells)
    SNOMED
    4421005
    LOINC
    LP14738-6
    UMLS CUI [1,3]
    C0332307 (Type - attribute)
    SNOMED
    261664005
    UMLS CUI [2,1]
    C2347026 (Biospecimen)
    UMLS CUI [2,2]
    C0007634 (Cells)
    SNOMED
    4421005
    LOINC
    LP14738-6
    UMLS CUI [2,3]
    C0449560 (Subtype (attribute))
    SNOMED
    260837004
    UMLS CUI [3,1]
    C1292533 (Tissue specimen)
    SNOMED
    119376003
    UMLS CUI [3,2]
    C0332307 (Type - attribute)
    SNOMED
    261664005
    UMLS CUI [4,1]
    C1292533 (Tissue specimen)
    SNOMED
    119376003
    UMLS CUI [4,2]
    C0449560 (Subtype (attribute))
    SNOMED
    260837004
    Primary tumor, metastasis, or transformed cell line
    Beschreibung

    PRIMARY_METASTATIC_TUMOR

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C0677930 (Primary Neoplasm)
    UMLS CUI [2,1]
    C0027627 (Neoplasm Metastasis)
    LOINC
    LP35033-7
    UMLS CUI [3,1]
    C0007601 (Cell Line, Transformed)
    Tumor stage of sample
    Beschreibung

    TUMOR_STAGE

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1300072 (Tumor stage)
    SNOMED
    371508000
    UMLS CUI [1,2]
    C0370003 (Specimen)
    SNOMED
    123038009
    LOINC
    LP7593-9
    Name of the center which conducted sequencing
    Beschreibung

    SEQUENCING_CENTER

    Datentyp

    string

    Alias
    UMLS CUI [1,1]
    C1301943 (Institution name)
    SNOMED
    398321007
    UMLS CUI [1,2]
    C0565990 (Medical center)
    SNOMED
    288565001
    UMLS CUI [1,3]
    C1561491 (Sequencing)

    Ähnliche Modelle

    This sample attributes table includes sample IDs, analyte type, tumor status, histological type, metastatic status, tumor stage and sequencing center.

    Name
    Typ
    Description | Question | Decode (Coded Value)
    Datentyp
    Alias
    Item Group
    pht004590
    C3846158 (UMLS CUI [1,1])
    SAMPLE_ID
    Item
    De-identified Sample ID
    string
    C4684638 (UMLS CUI [1,1])
    C1299222 (UMLS CUI [1,2])
    ANALYTE_TYPE
    Item
    Analyte Type
    string
    C4744818 (UMLS CUI [1,1])
    Item
    Tumor status
    text
    C0475752 (UMLS CUI [1,1])
    Code List
    Tumor status
    CL Item
    Is not a tumor (N)
    C0027651 (UMLS CUI [1,1])
    C1518422 (UMLS CUI [1,2])
    CL Item
    Is Tumor (Y)
    C0027651 (UMLS CUI [1,1])
    HISTOLOGICAL_TYPE
    Item
    Cell or tissue type or subtype of sample
    string
    C2347026 (UMLS CUI [1,1])
    C0007634 (UMLS CUI [1,2])
    C0332307 (UMLS CUI [1,3])
    C2347026 (UMLS CUI [2,1])
    C0007634 (UMLS CUI [2,2])
    C0449560 (UMLS CUI [2,3])
    C1292533 (UMLS CUI [3,1])
    C0332307 (UMLS CUI [3,2])
    C1292533 (UMLS CUI [4,1])
    C0449560 (UMLS CUI [4,2])
    PRIMARY_METASTATIC_TUMOR
    Item
    Primary tumor, metastasis, or transformed cell line
    string
    C0677930 (UMLS CUI [1,1])
    C0027627 (UMLS CUI [2,1])
    C0007601 (UMLS CUI [3,1])
    TUMOR_STAGE
    Item
    Tumor stage of sample
    string
    C1300072 (UMLS CUI [1,1])
    C0370003 (UMLS CUI [1,2])
    SEQUENCING_CENTER
    Item
    Name of the center which conducted sequencing
    string
    C1301943 (UMLS CUI [1,1])
    C0565990 (UMLS CUI [1,2])
    C1561491 (UMLS CUI [1,3])

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