Information:
Fel:
ID
45952
Beskrivning
Principal Investigator: Jared Roach, Institute for Systems Biology MeSH: Bipolar Disorder https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000866 This study examined the segregation of variants with phenotype in pedigrees harboring bipolar disorder.
Länk
Nyckelord
Versioner (1)
- 2024-03-16 2024-03-16 - Madita Rudolph
Rättsinnehavare
Jared Roach, Institute for Systems Biology
Uppladdad den
16 mars 2024
DOI
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Licens
Creative Commons BY 4.0
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dbGaP phs000866 Family Genomics of Bipolar Disorder
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
- Family ID, subject ID, mother ID, father ID, and sex variable of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
- Subject ID, sample ID, and sample use variable of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
- Subject ID, sex, and case or control subject status of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
- Sample ID, body site where sample was obtained, analyte type, tumor status, histological type, and sequencing center of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
- Family ID, subject ID, mother ID, father ID, and sex variable of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
- Subject ID, sample ID, and sample use variable of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
- Subject ID, sex, and case or control subject status of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
- Sample ID, body site where sample was obtained, analyte type, tumor status, histological type, and sequencing center of participants with or without bipolar disorder and involved in the "Family Genomics of Bipolar Disorder" project.
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
Elig.phs000866.v1.p1.1
Item
We chose a subset of individuals within each pedigree so as to maximize power under the most likely inheritance mode, as follows: (i) We sequenced a single affected individual and a single unaffected individual from pedigrees with a suggestive per-pedigree linkage peak and predicted dominant inheritance. (ii) We sequenced a parent-child trio or quartet from pedigrees with a single, suggestive per-pedigree linkage peak and either dominant or recessive inheritance. In pedigrees for which polygenic inheritance was more likely, we sequenced either (iii) a subset of affected individuals and 0-1 unaffected individuals or (iv) all available individuals.
boolean
C1516637 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,2])