ID

45943

Descripción

Principal Investigator: Andrea A. Baccarelli, MD, MPH, PhD, Harvard School of Public Health, Boston, MA, USA MeSH: Mortality,DNA Methylation https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000853 The Normative Aging Study (NAS) is a longitudinal study established by the United States Department of Veterans Affairs in 1963. Participants were male residents and free of chronic disease at the time of recruitment. Participants were invited to undergo an in-person examination every 3-5 years. Participants provided information on medical history, lifestyle and demographic factors and underwent a physical examination and laboratory tests, at each visit. Participants provided written informed consent at each visit, and the VA Boston Healthcare System Institutional Review Board approved the study.

Link

dbGaP study=phs000853

Palabras clave

  1. 10-03-24 10-03-24 - Madita Rudolph
Titular de derechos de autor

Andrea A. Baccarelli, MD, MPH, PhD, Harvard School of Public Health, Boston, MA, USA

Subido en

10 maart 2024

DOI

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Licencia

Creative Commons BY 4.0

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dbGaP phs000853 Normative Aging Study (NAS)

The dataset includes data of presence/absence of diagnoses of coronary heart disease, diabetes, hypertension, different types of white blood cells, e.g. basophils, eosinophils, lymphocytes, monocytes, neutrophiles, the ApoE4e status, the Hannum and Horvath predictor values per 5 years of methylation age, age at death (variable=Time_to_Death_NAS), as well as smoking status and basic sociodemographic data.

pht004429
Descripción

pht004429

Alias
UMLS CUI [1,1]
C3846158
De-identified Subject ID
Descripción

Subject_id_NAS

Tipo de datos

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
Death
Descripción

Death_Status_NAS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0011065
Time to death
Descripción

Time_to_Death_NAS

Tipo de datos

float

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C1301931
Years
Subject's age
Descripción

Age_in_years_NAS

Tipo de datos

float

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
Years
Education in years
Descripción

Years_Education_NAS

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0013658
Years
Diabetes
Descripción

Diabetes_NAS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0011849
Hypertension
Descripción

Hypertension_NAS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0020538
Coronary Hearth Diease
Descripción

Coronary_Heart_Disease_NAS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0010068
Number of Neutrophils
Descripción

Neutrophils_NAS

Tipo de datos

float

Unidades de medida
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0948762
1000 cells/mcL
Number of Lymphocytes
Descripción

Lymphocytes_NAS

Tipo de datos

float

Unidades de medida
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0200635
1000 cells/mcL
Number of Monocytes
Descripción

Monocytes_NAS

Tipo de datos

float

Unidades de medida
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0200637
1000 cells/mcL
Number of Eosinophils
Descripción

Eosinophils_NAS

Tipo de datos

float

Unidades de medida
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0200638
1000 cells/mcL
Number of basophils
Descripción

Basophils_NAS

Tipo de datos

float

Unidades de medida
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0200641
1000 cells/mcL
Smoking status
Descripción

Smoking_categories_NAS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1519386
APOE-e4 allele status
Descripción

APOEe4_NAS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1446118
Hannum predictor per 5 years of methylation age acceleration
Descripción

Hannum_5yr_NAS

Tipo de datos

float

Unidades de medida
  • Hannum/5 years of methylation age acceleration
Alias
UMLS CUI [1,1]
C2698872
UMLS CUI [1,2]
C0025723
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0000894
Hannum/5 years of methylation age acceleration
Horvath predictor per 5 years of methylation age acceleration
Descripción

Horvath_5yr_NAS

Tipo de datos

float

Unidades de medida
  • Horvath/5 years of methylation age acceleration
Alias
UMLS CUI [1,1]
C2698872
UMLS CUI [1,2]
C0025723
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0000894
Horvath/5 years of methylation age acceleration

Similar models

The dataset includes data of presence/absence of diagnoses of coronary heart disease, diabetes, hypertension, different types of white blood cells, e.g. basophils, eosinophils, lymphocytes, monocytes, neutrophiles, the ApoE4e status, the Hannum and Horvath predictor values per 5 years of methylation age, age at death (variable=Time_to_Death_NAS), as well as smoking status and basic sociodemographic data.

Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
pht004429
C3846158 (UMLS CUI [1,1])
Subject_id_NAS
Item
De-identified Subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
Item
Death
text
C0011065 (UMLS CUI [1,1])
Code List
Death
CL Item
No (0)
CL Item
Yes (1)
Time_to_Death_NAS
Item
Time to death
float
C1301931 (UMLS CUI [1,1])
Age_in_years_NAS
Item
Subject's age
float
C0001779 (UMLS CUI [1,1])
Years_Education_NAS
Item
Education in years
text
C0013658 (UMLS CUI [1,1])
Item
Diabetes
text
C0011849 (UMLS CUI [1,1])
Code List
Diabetes
CL Item
No (0)
CL Item
Yes (1)
Item
Hypertension
text
C0020538 (UMLS CUI [1,1])
Code List
Hypertension
CL Item
No (0)
CL Item
Yes (1)
Item
Coronary Hearth Diease
text
C0010068 (UMLS CUI [1,1])
Code List
Coronary Hearth Diease
CL Item
No (0)
CL Item
Yes (1)
Neutrophils_NAS
Item
Number of Neutrophils
float
C0948762 (UMLS CUI [1,1])
Lymphocytes_NAS
Item
Number of Lymphocytes
float
C0200635 (UMLS CUI [1,1])
Monocytes_NAS
Item
Number of Monocytes
float
C0200637 (UMLS CUI [1,1])
Eosinophils_NAS
Item
Number of Eosinophils
float
C0200638 (UMLS CUI [1,1])
Basophils_NAS
Item
Number of basophils
float
C0200641 (UMLS CUI [1,1])
Item
Smoking status
text
C1519386 (UMLS CUI [1,1])
Code List
Smoking status
CL Item
Never (0)
CL Item
Ever (1)
Item
APOE-e4 allele status
text
C1446118 (UMLS CUI [1,1])
Code List
APOE-e4 allele status
CL Item
No (0)
CL Item
Yes (1)
CL Item
Not applicable (NA)
C1272460 (UMLS CUI [1,1])
Hannum_5yr_NAS
Item
Hannum predictor per 5 years of methylation age acceleration
float
C2698872 (UMLS CUI [1,1])
C0025723 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0000894 (UMLS CUI [1,4])
Horvath_5yr_NAS
Item
Horvath predictor per 5 years of methylation age acceleration
float
C2698872 (UMLS CUI [1,1])
C0025723 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0000894 (UMLS CUI [1,4])

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