ID

45943

Beschrijving

Principal Investigator: Andrea A. Baccarelli, MD, MPH, PhD, Harvard School of Public Health, Boston, MA, USA MeSH: Mortality,DNA Methylation https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000853 The Normative Aging Study (NAS) is a longitudinal study established by the United States Department of Veterans Affairs in 1963. Participants were male residents and free of chronic disease at the time of recruitment. Participants were invited to undergo an in-person examination every 3-5 years. Participants provided information on medical history, lifestyle and demographic factors and underwent a physical examination and laboratory tests, at each visit. Participants provided written informed consent at each visit, and the VA Boston Healthcare System Institutional Review Board approved the study.

Link

dbGaP study=phs000853

Trefwoorden

  1. 10-03-24 10-03-24 - Madita Rudolph
Houder van rechten

Andrea A. Baccarelli, MD, MPH, PhD, Harvard School of Public Health, Boston, MA, USA

Geüploaded op

10 maart 2024

DOI

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Licentie

Creative Commons BY 4.0

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dbGaP phs000853 Normative Aging Study (NAS)

The dataset includes data of presence/absence of diagnoses of coronary heart disease, diabetes, hypertension, different types of white blood cells, e.g. basophils, eosinophils, lymphocytes, monocytes, neutrophiles, the ApoE4e status, the Hannum and Horvath predictor values per 5 years of methylation age, age at death (variable=Time_to_Death_NAS), as well as smoking status and basic sociodemographic data.

pht004429
Beschrijving

pht004429

Alias
UMLS CUI [1,1]
C3846158
De-identified Subject ID
Beschrijving

Subject_id_NAS

Datatype

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
Death
Beschrijving

Death_Status_NAS

Datatype

text

Alias
UMLS CUI [1,1]
C0011065
Time to death
Beschrijving

Time_to_Death_NAS

Datatype

float

Maateenheden
  • Years
Alias
UMLS CUI [1,1]
C1301931
Years
Subject's age
Beschrijving

Age_in_years_NAS

Datatype

float

Maateenheden
  • Years
Alias
UMLS CUI [1,1]
C0001779
Years
Education in years
Beschrijving

Years_Education_NAS

Datatype

text

Maateenheden
  • Years
Alias
UMLS CUI [1,1]
C0013658
Years
Diabetes
Beschrijving

Diabetes_NAS

Datatype

text

Alias
UMLS CUI [1,1]
C0011849
Hypertension
Beschrijving

Hypertension_NAS

Datatype

text

Alias
UMLS CUI [1,1]
C0020538
Coronary Hearth Diease
Beschrijving

Coronary_Heart_Disease_NAS

Datatype

text

Alias
UMLS CUI [1,1]
C0010068
Number of Neutrophils
Beschrijving

Neutrophils_NAS

Datatype

float

Maateenheden
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0948762
1000 cells/mcL
Number of Lymphocytes
Beschrijving

Lymphocytes_NAS

Datatype

float

Maateenheden
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0200635
1000 cells/mcL
Number of Monocytes
Beschrijving

Monocytes_NAS

Datatype

float

Maateenheden
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0200637
1000 cells/mcL
Number of Eosinophils
Beschrijving

Eosinophils_NAS

Datatype

float

Maateenheden
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0200638
1000 cells/mcL
Number of basophils
Beschrijving

Basophils_NAS

Datatype

float

Maateenheden
  • 1000 cells/mcL
Alias
UMLS CUI [1,1]
C0200641
1000 cells/mcL
Smoking status
Beschrijving

Smoking_categories_NAS

Datatype

text

Alias
UMLS CUI [1,1]
C1519386
APOE-e4 allele status
Beschrijving

APOEe4_NAS

Datatype

text

Alias
UMLS CUI [1,1]
C1446118
Hannum predictor per 5 years of methylation age acceleration
Beschrijving

Hannum_5yr_NAS

Datatype

float

Maateenheden
  • Hannum/5 years of methylation age acceleration
Alias
UMLS CUI [1,1]
C2698872
UMLS CUI [1,2]
C0025723
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0000894
Hannum/5 years of methylation age acceleration
Horvath predictor per 5 years of methylation age acceleration
Beschrijving

Horvath_5yr_NAS

Datatype

float

Maateenheden
  • Horvath/5 years of methylation age acceleration
Alias
UMLS CUI [1,1]
C2698872
UMLS CUI [1,2]
C0025723
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0000894
Horvath/5 years of methylation age acceleration

Similar models

The dataset includes data of presence/absence of diagnoses of coronary heart disease, diabetes, hypertension, different types of white blood cells, e.g. basophils, eosinophils, lymphocytes, monocytes, neutrophiles, the ApoE4e status, the Hannum and Horvath predictor values per 5 years of methylation age, age at death (variable=Time_to_Death_NAS), as well as smoking status and basic sociodemographic data.

Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Item Group
pht004429
C3846158 (UMLS CUI [1,1])
Subject_id_NAS
Item
De-identified Subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
Item
Death
text
C0011065 (UMLS CUI [1,1])
Code List
Death
CL Item
No (0)
CL Item
Yes (1)
Time_to_Death_NAS
Item
Time to death
float
C1301931 (UMLS CUI [1,1])
Age_in_years_NAS
Item
Subject's age
float
C0001779 (UMLS CUI [1,1])
Years_Education_NAS
Item
Education in years
text
C0013658 (UMLS CUI [1,1])
Item
Diabetes
text
C0011849 (UMLS CUI [1,1])
Code List
Diabetes
CL Item
No (0)
CL Item
Yes (1)
Item
Hypertension
text
C0020538 (UMLS CUI [1,1])
Code List
Hypertension
CL Item
No (0)
CL Item
Yes (1)
Item
Coronary Hearth Diease
text
C0010068 (UMLS CUI [1,1])
Code List
Coronary Hearth Diease
CL Item
No (0)
CL Item
Yes (1)
Neutrophils_NAS
Item
Number of Neutrophils
float
C0948762 (UMLS CUI [1,1])
Lymphocytes_NAS
Item
Number of Lymphocytes
float
C0200635 (UMLS CUI [1,1])
Monocytes_NAS
Item
Number of Monocytes
float
C0200637 (UMLS CUI [1,1])
Eosinophils_NAS
Item
Number of Eosinophils
float
C0200638 (UMLS CUI [1,1])
Basophils_NAS
Item
Number of basophils
float
C0200641 (UMLS CUI [1,1])
Item
Smoking status
text
C1519386 (UMLS CUI [1,1])
Code List
Smoking status
CL Item
Never (0)
CL Item
Ever (1)
Item
APOE-e4 allele status
text
C1446118 (UMLS CUI [1,1])
Code List
APOE-e4 allele status
CL Item
No (0)
CL Item
Yes (1)
CL Item
Not applicable (NA)
C1272460 (UMLS CUI [1,1])
Hannum_5yr_NAS
Item
Hannum predictor per 5 years of methylation age acceleration
float
C2698872 (UMLS CUI [1,1])
C0025723 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0000894 (UMLS CUI [1,4])
Horvath_5yr_NAS
Item
Horvath predictor per 5 years of methylation age acceleration
float
C2698872 (UMLS CUI [1,1])
C0025723 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0000894 (UMLS CUI [1,4])

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