ID

45942

Beschreibung

Principal Investigator: E. Jane Costello, PhD, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA MeSH: Substance-Related Disorders https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000852 1. Great Smoky Mountains Study (GSMS; Costello et al. 1996, 1997) Three cohorts of boys and girls, aged 9, 11, and 13 years at intake in 1993, were selected from a rural population of some 20,000 children using a household equal probability design. A two-phase procedure was used for White and African-American youth to increase power by oversampling children at risk for psychiatric and SUDs. Parents (usually mothers) of the first stage random population sample completed a questionnaire about their child's behavioral problems. Of 4,195 subjects selected, 95% (N=3,896) of parents completed the screen. All children scoring above a predetermined threshold (the top 25% of the total scores), plus a 10% random sample of the remaining 75%, were recruited for detailed interviews. Results can be back-weighted to population levels for analyses. Half of the sample consists of females, and 6% are African Americans, reflecting the population of the study area. The interviewed sample of white and African-American subjects was 1,070 (80% of those recruited). American Indian youth were oversampled (100%) because they are an understudied group known to be at high risk for stressful events, substance disorders, and mood disorders. Of 431 age-eligible children, 350 (81% boys, 49% girls) participated. Thus, the size of total GSMS sample is 1,070 + 350 = 1,420. Data collection is complete for ages 9-26, and age 30 interviews are in progress. By age 26 a total of 9,858 interviews had been completed; the average number of interviews per subject was seven, and by age 26, 97.3% completed two or more interviews. 2. The Caring for Children in the Community Study (CCC; Angold et al., 2002) This representative study of psychiatric illness and service use in African-American and White youth took place in four rural counties in the southeastern USA. The two-stage sampling design and methods are similar to those used in the GSMS. Of 4,500 youth randomly selected from the 17,117 9- to 17-year-olds in the public school's database, 3,613 (80.0%) were successfully contacted and agreed to complete the behavioral screen. Of the 1,302 selected to participate in the study, 920 (70.7%) interviews were completed. Because CCC was also the only study in GEDI to contain more than a very few African-American participants, these were omitted from the multi-site analyses. Reprinted with permission from Cambridge University Press from Costello et al., 2013: PMID: 23461817 References: Costello et al., 1996: PMID: 8956679 Costello et al., 1997: PMID: 9184514 Angold et al., 2002: PMID: 12365876

Link

dbGaP study=phs000852

Stichworte

  1. 10.03.24 10.03.24 - Madita Rudolph
Rechteinhaber

E. Jane Costello, PhD, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA

Hochgeladen am

10. März 2024

DOI

Für eine Beantragung loggen Sie sich ein.

Lizenz

Creative Commons BY 4.0

Modell Kommentare :

Hier können Sie das Modell kommentieren. Über die Sprechblasen an den Itemgruppen und Items können Sie diese spezifisch kommentieren.

Itemgroup Kommentare für :

Item Kommentare für :

Um Formulare herunterzuladen müssen Sie angemeldet sein. Bitte loggen Sie sich ein oder registrieren Sie sich kostenlos.

dbGaP phs000852 GEDI: A Developmental Model of Gene-Environment Interplay in SUDs

Eligibility Criteria

Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
In each of the samples, single nucleotide polymorphisms (SNPs) with missing rate > 0.01, minor allele frequency (MAF) < 0.05, or extreme deviation (p < 1-6) from the Hardy-Weinberg equilibrium (HWE) were removed from further analysis. Subjects with missing rate > 0.01 or unusual genome-wide homozygosity (|normalized homozygosity rate| > 5) were excluded.
Beschreibung

Elig.phs000852.v1.p1.1

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0752046
UMLS CUI [1,3]
C1285573
UMLS CUI [1,4]
C1705236
Reprinted with permission from Cambridge University Press from Costello et al., 2013: PMID: 23461817.
Beschreibung

Elig.phs000852.v1.p1.2

Datentyp

boolean

Alias
UMLS CUI [1,1]
C3846158

Ähnliche Modelle

Eligibility Criteria

Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs000852.v1.p1.1
Item
In each of the samples, single nucleotide polymorphisms (SNPs) with missing rate > 0.01, minor allele frequency (MAF) < 0.05, or extreme deviation (p < 1-6) from the Hardy-Weinberg equilibrium (HWE) were removed from further analysis. Subjects with missing rate > 0.01 or unusual genome-wide homozygosity (|normalized homozygosity rate| > 5) were excluded.
boolean
C0680251 (UMLS CUI [1,1])
C0752046 (UMLS CUI [1,2])
C1285573 (UMLS CUI [1,3])
C1705236 (UMLS CUI [1,4])
Elig.phs000852.v1.p1.2
Item
Reprinted with permission from Cambridge University Press from Costello et al., 2013: PMID: 23461817.
boolean
C3846158 (UMLS CUI [1,1])

Benutzen Sie dieses Formular für Rückmeldungen, Fragen und Verbesserungsvorschläge.

Mit * gekennzeichnete Felder sind notwendig.

Benötigen Sie Hilfe bei der Suche? Um mehr Details zu erfahren und die Suche effektiver nutzen zu können schauen Sie sich doch das entsprechende Video auf unserer Tutorial Seite an.

Zum Video