ID

45895

Beschreibung

Principal Investigator: Bernice Porjesz, PhD, SUNY Health Sciences Center, New York, NY, USA MeSH: Alcoholism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000976 COGA is a family study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US. COGA has gathered detailed, standardized data on study participants, including diagnostic and neurophysiological assessments. This sample has already proved successful in identifying several genes that influence the risk for alcoholism and neurophysiological endophenotypes, which have been independently replicated. COGA data were included as part of two Genetic Analysis Workshops, and the phenotypes are familiar to the genetics community. Alcoholic probands were recruited from treatment facilities, assessed by personal interview, and after securing permission, other family members were also assessed. A set of comparison families was drawn from the same communities as the families recruited through an alcoholic proband. Assessment involved a detailed personal interview developed for this project, the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), which gathers detailed information on alcoholism related symptoms along with other drugs and psychiatric symptoms. Many participants also came to the laboratories for electroencephalographic studies. Neurophysiological features that have been shown to be useful endophenotypes for which we have linkage and in some cases association results are included on a subset of the case-control sample: the beta power of the resting electroencephalogram (EEG), the P3(00) amplitude of the visual event-related potential (ERP), and the theta and delta event-related oscillations (EROs) underlying the P3. As part of COGA, a set of informative African American families were selected to have Genome-Wide Association data obtained within families. Genotyping was performed using the Illumina Omni2.5_080814_1 chip to genotype 3,438 subjects selected from densely affected families. Genotyping was performed at CIDR. This sample complements a set of densely affected European American families previously made available under dbGaP study accession phs000763. In addition, exome sequencing data on a subset of individuals with GWAS were added in version 2.

Link

dbGaP study = phs000976

Stichworte

Versionen (1)
  1. 08.12.23 08.12.23 - Simon Heim
Rechteinhaber

Bernice Porjesz, PhD, SUNY Health Sciences Center, New York, NY, USA

Hochgeladen am

8. Dezember 2023

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs000976 COGA: African American Family GWAS

Englisch

Eligibility Criteria

6 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
Beschreibung

COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.

Datentyp

boolean

Alias
UMLS CUI [1,1]
C2949735
UMLS CUI [1,2]
C0033873
UMLS CUI [1,3]
C0029921
UMLS CUI [1,4]
C0021562
UMLS CUI [1,5]
C2919052
UMLS CUI [2,1]
C0150543
UMLS CUI [2,2]
C0205197
A potential proband: must not have used intravenous drugs more than 30 times lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas:
Beschreibung

A potential proband: must not have used intravenous drugs more than 30 times lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas:

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1948021
UMLS CUI [1,2]
C3245505
UMLS CUI [1,3]
C2242868
UMLS CUI [1,4]
C1518422
UMLS CUI [1,5]
C0449809
UMLS CUI [1,6]
C0332168
UMLS CUI [2,1]
C1948021
UMLS CUI [2,2]
C3245505
UMLS CUI [2,3]
C2986417
UMLS CUI [2,4]
C3846017
UMLS CUI [2,5]
C0332300
UMLS CUI [2,6]
C0236664
UMLS CUI [2,7]
C0679247
UMLS CUI [2,8]
C0349464
UMLS CUI [2,9]
C0023890
UMLS CUI [3,1]
C1948021
UMLS CUI [3,2]
C3245505
UMLS CUI [3,3]
C2986417
UMLS CUI [3,4]
C0019693
UMLS CUI [4,1]
C1948021
UMLS CUI [4,2]
C3245505
UMLS CUI [4,3]
C1517194
UMLS CUI [4,4]
C0581906
UMLS CUI [4,5]
C0681784
UMLS CUI [4,6]
C0237096
Each COGA site recruited control families consisting of two living parents and three or more full siblings, aged 14 or older. The control probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were representative of the general population and did not have to be unaffected individuals. Therefore, a control family would not be eliminated if alcoholism was present among any of its members.
Beschreibung

Each COGA site recruited control families consisting of two living parents and three or more full siblings, aged 14 or older. The control probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were representative of the general population and did not have to be unaffected individuals. Therefore, a control family would not be eliminated if alcoholism was present among any of its members.

Datentyp

boolean

Alias
UMLS CUI [1,1]
C2825164
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0015576
UMLS CUI [1,4]
C0449961
UMLS CUI [1,5]
C0030551
UMLS CUI [1,6]
C0557094
UMLS CUI [1,7]
C0001779
UMLS CUI [2,1]
C1948021
UMLS CUI [2,2]
C0015576
UMLS CUI [2,3]
C0150105
UMLS CUI [2,4]
C0018720
UMLS CUI [2,5]
C0011344
UMLS CUI [3,1]
C1882932
UMLS CUI [3,2]
C0683971
UMLS CUI [3,3]
C0522476
UMLS CUI [3,4]
C2986417
We extended families through all affected, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affected members. If any of these relatives was affected, we extended to his/her first-degree relatives, and continued if any of them was affected. In addition, extension by leapfrogging over a living or dead unaffected went to a branch containing at least two first-degree "leapfrog" relatives who had 3 implications by history.
Beschreibung

We extended families through all affected, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affected members. If any of these relatives was affected, we extended to his/her first-degree relatives, and continued if any of them was affected. In addition, extension by leapfrogging over a living or dead unaffected went to a branch containing at least two first-degree "leapfrog" relatives who had 3 implications by history.

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1704788
UMLS CUI [1,2]
C0015576
UMLS CUI [1,3]
C1517194
UMLS CUI [1,4]
C1546956
UMLS CUI [1,5]
C2584946
UMLS CUI [1,6]
C2599718
UMLS CUI [1,7]
C0809949
UMLS CUI [2,1]
C0080103
UMLS CUI [2,2]
C0392760
UMLS CUI [2,3]
C0439792
UMLS CUI [2,4]
C2348561
UMLS CUI [2,5]
C1517194
UMLS CUI [3,1]
C0560435
UMLS CUI [3,2]
C0237401
UMLS CUI [3,3]
C2348562
UMLS CUI [3,4]
C0262926
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Ähnliche Modelle

Eligibility Criteria

6 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
Item
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
boolean
C2949735 (UMLS CUI [1,1])
C0033873 (UMLS CUI [1,2])
C0029921 (UMLS CUI [1,3])
C0021562 (UMLS CUI [1,4])
C2919052 (UMLS CUI [1,5])
C0150543 (UMLS CUI [2,1])
C0205197 (UMLS CUI [2,2])
A potential proband: must not have used intravenous drugs more than 30 times lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas:
Item
A potential proband: must not have used intravenous drugs more than 30 times lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas:
boolean
C1948021 (UMLS CUI [1,1])
C3245505 (UMLS CUI [1,2])
C2242868 (UMLS CUI [1,3])
C1518422 (UMLS CUI [1,4])
C0449809 (UMLS CUI [1,5])
C0332168 (UMLS CUI [1,6])
C1948021 (UMLS CUI [2,1])
C3245505 (UMLS CUI [2,2])
C2986417 (UMLS CUI [2,3])
C3846017 (UMLS CUI [2,4])
C0332300 (UMLS CUI [2,5])
C0236664 (UMLS CUI [2,6])
C0679247 (UMLS CUI [2,7])
C0349464 (UMLS CUI [2,8])
C0023890 (UMLS CUI [2,9])
C1948021 (UMLS CUI [3,1])
C3245505 (UMLS CUI [3,2])
C2986417 (UMLS CUI [3,3])
C0019693 (UMLS CUI [3,4])
C1948021 (UMLS CUI [4,1])
C3245505 (UMLS CUI [4,2])
C1517194 (UMLS CUI [4,3])
C0581906 (UMLS CUI [4,4])
C0681784 (UMLS CUI [4,5])
C0237096 (UMLS CUI [4,6])
Each COGA site recruited control families consisting of two living parents and three or more full siblings, aged 14 or older. The control probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were representative of the general population and did not have to be unaffected individuals. Therefore, a control family would not be eliminated if alcoholism was present among any of its members.
Item
Each COGA site recruited control families consisting of two living parents and three or more full siblings, aged 14 or older. The control probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were representative of the general population and did not have to be unaffected individuals. Therefore, a control family would not be eliminated if alcoholism was present among any of its members.
boolean
C2825164 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0015576 (UMLS CUI [1,3])
C0449961 (UMLS CUI [1,4])
C0030551 (UMLS CUI [1,5])
C0557094 (UMLS CUI [1,6])
C0001779 (UMLS CUI [1,7])
C1948021 (UMLS CUI [2,1])
C0015576 (UMLS CUI [2,2])
C0150105 (UMLS CUI [2,3])
C0018720 (UMLS CUI [2,4])
C0011344 (UMLS CUI [2,5])
C1882932 (UMLS CUI [3,1])
C0683971 (UMLS CUI [3,2])
C0522476 (UMLS CUI [3,3])
C2986417 (UMLS CUI [3,4])
We extended families through all affected, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affected members. If any of these relatives was affected, we extended to his/her first-degree relatives, and continued if any of them was affected. In addition, extension by leapfrogging over a living or dead unaffected went to a branch containing at least two first-degree "leapfrog" relatives who had 3 implications by history.
Item
We extended families through all affected, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affected members. If any of these relatives was affected, we extended to his/her first-degree relatives, and continued if any of them was affected. In addition, extension by leapfrogging over a living or dead unaffected went to a branch containing at least two first-degree "leapfrog" relatives who had 3 implications by history.
boolean
C1704788 (UMLS CUI [1,1])
C0015576 (UMLS CUI [1,2])
C1517194 (UMLS CUI [1,3])
C1546956 (UMLS CUI [1,4])
C2584946 (UMLS CUI [1,5])
C2599718 (UMLS CUI [1,6])
C0809949 (UMLS CUI [1,7])
C0080103 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0439792 (UMLS CUI [2,3])
C2348561 (UMLS CUI [2,4])
C1517194 (UMLS CUI [2,5])
C0560435 (UMLS CUI [3,1])
C0237401 (UMLS CUI [3,2])
C2348562 (UMLS CUI [3,3])
C0262926 (UMLS CUI [3,4])
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