ID

45893

Descrizione

Principal Investigator: Stephen T. McGarvey, PhD, MPH, Brown University, Providence, RI, USA MeSH: Obesity,Adiposity,Lipids,Blood Pressure https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000972 The individuals sequenced here represent a small subset of the parent study (described below) and were carefully selected for the purpose of creating a Samoan-specific reference panel for imputation back into the parent study. The INFOSTIP algorithm of Gusev et. al. (2012) (PMID: 22135348) was used to optimally choose the individuals for sequencing. The research goal of the parent study (dbGaP ID phs000914) is to identify genetic variation that increases susceptibility to obesity and cardiometabolic phenotypes among adult Samoans using genome-wide association (GWAS) methods. DNA from peripheral blood and phenotypic information were collected from 3,119 adult Samoans, 23 to 70 years of age. The participants reside throughout the independent nation of Samoa, which is experiencing economic development and the nutrition transition. Genotyping was performed with the Affymetrix Genome-Wide Human SNP 6.0 Array using a panel of approximately 900,000 SNPs. Anthropometric, fasting blood biomarkers and detailed dietary, physical activity, health and socio-demographic variables were collected. We are replicating the GWAS findings in an independent sample of 2,500 Samoans from earlier studies. After replication of genomic regions and informative SNPs in those regions, we will determine sequences of the important genes, and determine the specific genetic variants in the sequenced genes that are associated with adiposity and related cardiometabolic conditions. We will also identify gene by environment interactions, focusing on dietary intake patterns and nutrients.

collegamento

dbGaP study = phs000972

Keywords

versioni (1)
  1. 01/12/23 01/12/23 - Simon Heim
Titolare del copyright

Stephen T. McGarvey, PhD, MPH, Brown University, Providence, RI, USA

Caricato su

1 dicembre 2023

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
Commenti del modello :

Puoi commentare il modello dati qui. Tramite i fumetti nei gruppi di articoli e articoli è possibile aggiungere commenti a quelli in modo specifico.

Torna ai commenti del modello
Commenti del gruppo di articoli per :

Commenti dell'articolo per :

Per scaricare i modelli di dati devi essere registrato. Per favore accesso o registrati GRATIS.

dbGaP phs000972 NHLBI TOPMed: Genome-Wide Association Study of Adiposity in Samoans

Inglese

Eligibility Criteria

4 moduli  
Inclusion and exclusion criteria
Descrizione

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
Participants were eligible for inclusion in the parent study (from which these sequenced individuals were selected) if they self-reported having four Samoan grandparents, if they were 23-70 years of age, not pregnant, able to complete questionnaires and anthropometric measures, and able and willing to complete the interview portions of the study in Samoan. For more detail, please see the following publication, which describes the origin of the parent dataset: Hawley NL, Minster RL, Weeks DE, Viali S, Reupena MS, Sun G, Cheng H, Deka R, McGarvey ST. Prevalence of Adiposity and Associated Cardiometabolic Risk Factors in the Samoan Genome-Wide Association Study. Am J Human Biol 2014. 26: 491-501. DOI: 10.1002/jhb.22553. PMID: 24799123. PMCID: PMC4292846. The individuals sequenced here represent a subset of the parent study and were carefully selected for the purpose of creating a Samoan-specific reference panel for imputation back into the parent study. The INFOSTIP algorithm of Gusev et. al. (2012) (PMID: 22135348) was used to optimally choose the individuals for sequencing.
Descrizione

Participants were eligible for inclusion in the parent study (from which these sequenced individuals were selected) if they self-reported having four Samoan grandparents, if they were 23-70 years of age, not pregnant, able to complete questionnaires and anthropometric measures, and able and willing to complete the interview portions of the study in Samoan. For more detail, please see the following publication, which describes the origin of the parent dataset: Hawley NL, Minster RL, Weeks DE, Viali S, Reupena MS, Sun G, Cheng H, Deka R, McGarvey ST. Prevalence of Adiposity and Associated Cardiometabolic Risk Factors in the Samoan Genome-Wide Association Study. Am J Human Biol 2014. 26: 491-501. DOI: 10.1002/jhb.22553. PMID: 24799123. PMCID: PMC4292846. The individuals sequenced here represent a subset of the parent study and were carefully selected for the purpose of creating a Samoan-specific reference panel for imputation back into the parent study. The INFOSTIP algorithm of Gusev et. al. (2012) (PMID: 22135348) was used to optimally choose the individuals for sequencing.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0013893
UMLS CUI [1,2]
C2699423
UMLS CUI [1,3]
C0947630
UMLS CUI [1,4]
C1707391
UMLS CUI [1,5]
C5707708
UMLS CUI [1,6]
C1556103
UMLS CUI [1,7]
C0337471
UMLS CUI [1,8]
C0001779
UMLS CUI [1,9]
C0232973
UMLS CUI [1,10]
C0085732
UMLS CUI [1,11]
C0600109
UMLS CUI [1,12]
C0034394
UMLS CUI [1,13]
C2598146
UMLS CUI [1,14]
C0574401
UMLS CUI [1,15]
C1704324
UMLS CUI [1,16]
C0150098
UMLS CUI [2,1]
C0033105
UMLS CUI [2,2]
C1563743
UMLS CUI [2,3]
C5392236
UMLS CUI [2,4]
C2350277
UMLS CUI [2,5]
C0242537
UMLS CUI [3,1]
C1294197
UMLS CUI [3,2]
C1882932
UMLS CUI [3,3]
C1515021
UMLS CUI [3,4]
C2699423
UMLS CUI [3,5]
C0947630
UMLS CUI [3,6]
C0242802
UMLS CUI [3,7]
C4266518
UMLS CUI [3,8]
C1556103
UMLS CUI [4,1]
C0002045
UMLS CUI [4,2]
C0242802
UMLS CUI [4,3]
C1294197
Ritorna all'inizio della pagina

Similar models

Eligibility Criteria

4 moduli
Name
genere
Description | Question | Decode (Coded Value)
Tipo di dati
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Participants were eligible for inclusion in the parent study (from which these sequenced individuals were selected) if they self-reported having four Samoan grandparents, if they were 23-70 years of age, not pregnant, able to complete questionnaires and anthropometric measures, and able and willing to complete the interview portions of the study in Samoan. For more detail, please see the following publication, which describes the origin of the parent dataset: Hawley NL, Minster RL, Weeks DE, Viali S, Reupena MS, Sun G, Cheng H, Deka R, McGarvey ST. Prevalence of Adiposity and Associated Cardiometabolic Risk Factors in the Samoan Genome-Wide Association Study. Am J Human Biol 2014. 26: 491-501. DOI: 10.1002/jhb.22553. PMID: 24799123. PMCID: PMC4292846. The individuals sequenced here represent a subset of the parent study and were carefully selected for the purpose of creating a Samoan-specific reference panel for imputation back into the parent study. The INFOSTIP algorithm of Gusev et. al. (2012) (PMID: 22135348) was used to optimally choose the individuals for sequencing.
Item
Participants were eligible for inclusion in the parent study (from which these sequenced individuals were selected) if they self-reported having four Samoan grandparents, if they were 23-70 years of age, not pregnant, able to complete questionnaires and anthropometric measures, and able and willing to complete the interview portions of the study in Samoan. For more detail, please see the following publication, which describes the origin of the parent dataset: Hawley NL, Minster RL, Weeks DE, Viali S, Reupena MS, Sun G, Cheng H, Deka R, McGarvey ST. Prevalence of Adiposity and Associated Cardiometabolic Risk Factors in the Samoan Genome-Wide Association Study. Am J Human Biol 2014. 26: 491-501. DOI: 10.1002/jhb.22553. PMID: 24799123. PMCID: PMC4292846. The individuals sequenced here represent a subset of the parent study and were carefully selected for the purpose of creating a Samoan-specific reference panel for imputation back into the parent study. The INFOSTIP algorithm of Gusev et. al. (2012) (PMID: 22135348) was used to optimally choose the individuals for sequencing.
boolean
C0013893 (UMLS CUI [1,1])
C2699423 (UMLS CUI [1,2])
C0947630 (UMLS CUI [1,3])
C1707391 (UMLS CUI [1,4])
C5707708 (UMLS CUI [1,5])
C1556103 (UMLS CUI [1,6])
C0337471 (UMLS CUI [1,7])
C0001779 (UMLS CUI [1,8])
C0232973 (UMLS CUI [1,9])
C0085732 (UMLS CUI [1,10])
C0600109 (UMLS CUI [1,11])
C0034394 (UMLS CUI [1,12])
C2598146 (UMLS CUI [1,13])
C0574401 (UMLS CUI [1,14])
C1704324 (UMLS CUI [1,15])
C0150098 (UMLS CUI [1,16])
C0033105 (UMLS CUI [2,1])
C1563743 (UMLS CUI [2,2])
C5392236 (UMLS CUI [2,3])
C2350277 (UMLS CUI [2,4])
C0242537 (UMLS CUI [2,5])
C1294197 (UMLS CUI [3,1])
C1882932 (UMLS CUI [3,2])
C1515021 (UMLS CUI [3,3])
C2699423 (UMLS CUI [3,4])
C0947630 (UMLS CUI [3,5])
C0242802 (UMLS CUI [3,6])
C4266518 (UMLS CUI [3,7])
C1556103 (UMLS CUI [3,8])
C0002045 (UMLS CUI [4,1])
C0242802 (UMLS CUI [4,2])
C1294197 (UMLS CUI [4,3])
Ritorna all'inizio della pagina 

Contatto

Si prega di utilizzare questo modulo per feedback, domande e suggerimenti per miglioramenti.

I campi contrassegnati da * sono obbligatori.

Aiuto

Do you need help on how to use the search function? Please watch the corresponding tutorial video for more details and learn how to use the search function most efficiently.

Watch Tutorial