ID

45873

Description

Principal Investigator: Patrick Ellinor, MD, PhD, Massachusetts General Hospital, Boston, MA, USA MeSH: Atrial Fibrillation https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001001 The Massachusetts General Hospital (MGH) Atrial Fibrillation Study was initiated in 2001. The study has enrolled serial probands, unaffected and affected family members with atrial fibrillation. At enrollment participants undergo a structured interview to systematically capture their past medical history, AF treatments, and family history. An electrocardiogram is performed; the results of an echocardiogram are obtained; and blood samples are obtained. *The Massachusetts General Hospital (MGH) Atrial Fibrillation Study is utilized in the following dbGaP substudies.* To view genotypes, analysis, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" box located on the right hand side of this top-level study page phs001001 Massachusetts General Hospital (MGH) Atrial Fibrillation Study.- phs001116 MGH AF CHARGE-S - phs001117 MGH AF Exome Sequencing - phs001118 MGH AF Medical Resequencing

Link

dbGaP study = phs001001

Keywords

  1. 10/27/23 10/27/23 - Simon Heim
Copyright Holder

Patrick Ellinor, MD, PhD, Massachusetts General Hospital, Boston, MA, USA

Uploaded on

October 27, 2023

DOI

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License

Creative Commons BY 4.0

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dbGaP phs001001 MGH Atrial Fibrillation Study

This subject phenotype data table includes subject's sex, race, ethnicity, atrial fibrillation status, age of diagnosis, status at enrollment for age, height, weight, hypertension, diabetes, heart failure, and myocardial infarction. Measurements included are cholesterol (TC, HDL, LDL, and triglycerides) and echocardiogram (PR, QRS, and QT intervals).

  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The subject consent data table contains subject IDs, consent group information, subject aliases, and affection status for atrial fibrillation (AF).
    3. This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use and substudy accession.
    4. This subject phenotype data table includes subject's sex, race, ethnicity, atrial fibrillation status, age of diagnosis, status at enrollment for age, height, weight, hypertension, diabetes, heart failure, and myocardial infarction. Measurements included are cholesterol (TC, HDL, LDL, and triglycerides) and echocardiogram (PR, QRS, and QT intervals).
    5. This MGH AF CHARGE-S sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    6. This MGH Exome Sequencing in Early AF sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    7. This MGH AF Resequencing sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    8. This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, and sex of subjects.
pht005655
Description

pht005655

Alias
UMLS CUI [1,1]
C3846158
De-identified Subject ID
Description

SUBJECT_ID

Data type

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
Race of participant
Description

race

Data type

string

Alias
UMLS CUI [1,1]
C0034510
AF status
Description

af_status

Data type

string

Alias
UMLS CUI [1,1]
C0004238
UMLS CUI [1,2]
C0449437
Age at enrollment
Description

age

Data type

float

Measurement units
  • years
Alias
UMLS CUI [1,1]
C5236162
years
Age at AF diagnosis
Description

age_diagnosis

Data type

float

Measurement units
  • years
Alias
UMLS CUI [1,1]
C1828181
UMLS CUI [1,2]
C0004238
years
Gender of participant
Description

sex

Data type

string

Alias
UMLS CUI [1,1]
C0079399
Ethnicity of participant
Description

ethnicity

Data type

string

Alias
UMLS CUI [1,1]
C5441552
Subject's height
Description

height

Data type

float

Measurement units
  • inches
Alias
UMLS CUI [1,1]
C0489786
inches
Subject's weight
Description

weight

Data type

float

Measurement units
  • pounds
Alias
UMLS CUI [1,1]
C0005910
pounds
Hypertension at enrollment
Description

hypertension

Data type

string

Alias
UMLS CUI [1,1]
C0020538
UMLS CUI [1,2]
C1442880
UMLS CUI [1,3]
C1516879
Diabetes at enrollment
Description

diabetes

Data type

string

Alias
UMLS CUI [1,1]
C0011849
UMLS CUI [1,2]
C1442880
UMLS CUI [1,3]
C1516879
Heart failure at enrollment
Description

heart_failure

Data type

string

Alias
UMLS CUI [1,1]
C0018801
UMLS CUI [1,2]
C1442880
UMLS CUI [1,3]
C1516879
Myocardial infarction at enrollment
Description

myocardial_infarction

Data type

string

Alias
UMLS CUI [1,1]
C0027051
UMLS CUI [1,2]
C1442880
UMLS CUI [1,3]
C1516879
Total cholesterol
Description

TC

Data type

float

Measurement units
  • milligrams per deciliter
Alias
UMLS CUI [1,1]
C1445957
milligrams per deciliter
High-density lipoprotein
Description

HDL

Data type

float

Measurement units
  • milligrams per deciliter
Alias
UMLS CUI [1,1]
C0392885
milligrams per deciliter
Low-density lipoprotein
Description

LDL

Data type

float

Measurement units
  • milligrams per deciliter
Alias
UMLS CUI [1,1]
C0202117
milligrams per deciliter
Triglycerides
Description

Triglycerides

Data type

float

Measurement units
  • milligrams per deciliter
Alias
UMLS CUI [1,1]
C0202236
milligrams per deciliter
ECG - PR Interval
Description

ECG_PR_int

Data type

float

Measurement units
  • milliseconds
Alias
UMLS CUI [1,1]
C0429087
milliseconds
ECG - QRS Interval
Description

ECG_QRS_int

Data type

float

Measurement units
  • milliseconds
Alias
UMLS CUI [1,1]
C0429025
milliseconds
ECG - QT Interval
Description

ECG_QT_int

Data type

float

Measurement units
  • milliseconds
Alias
UMLS CUI [1,1]
C1287082
milliseconds
ECG - ventricular rate
Description

ECG_ventricular_rate

Data type

float

Measurement units
  • beats per minute
Alias
UMLS CUI [1,1]
C2189285
beats per minute

Similar models

This subject phenotype data table includes subject's sex, race, ethnicity, atrial fibrillation status, age of diagnosis, status at enrollment for age, height, weight, hypertension, diabetes, heart failure, and myocardial infarction. Measurements included are cholesterol (TC, HDL, LDL, and triglycerides) and echocardiogram (PR, QRS, and QT intervals).

  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The subject consent data table contains subject IDs, consent group information, subject aliases, and affection status for atrial fibrillation (AF).
    3. This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use and substudy accession.
    4. This subject phenotype data table includes subject's sex, race, ethnicity, atrial fibrillation status, age of diagnosis, status at enrollment for age, height, weight, hypertension, diabetes, heart failure, and myocardial infarction. Measurements included are cholesterol (TC, HDL, LDL, and triglycerides) and echocardiogram (PR, QRS, and QT intervals).
    5. This MGH AF CHARGE-S sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    6. This MGH Exome Sequencing in Early AF sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    7. This MGH AF Resequencing sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    8. This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, and sex of subjects.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
pht005655
C3846158 (UMLS CUI [1,1])
SUBJECT_ID
Item
De-identified Subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
race
Item
Race of participant
string
C0034510 (UMLS CUI [1,1])
af_status
Item
AF status
string
C0004238 (UMLS CUI [1,1])
C0449437 (UMLS CUI [1,2])
age
Item
Age at enrollment
float
C5236162 (UMLS CUI [1,1])
age_diagnosis
Item
Age at AF diagnosis
float
C1828181 (UMLS CUI [1,1])
C0004238 (UMLS CUI [1,2])
sex
Item
Gender of participant
string
C0079399 (UMLS CUI [1,1])
ethnicity
Item
Ethnicity of participant
string
C5441552 (UMLS CUI [1,1])
height
Item
Subject's height
float
C0489786 (UMLS CUI [1,1])
weight
Item
Subject's weight
float
C0005910 (UMLS CUI [1,1])
hypertension
Item
Hypertension at enrollment
string
C0020538 (UMLS CUI [1,1])
C1442880 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
diabetes
Item
Diabetes at enrollment
string
C0011849 (UMLS CUI [1,1])
C1442880 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
heart_failure
Item
Heart failure at enrollment
string
C0018801 (UMLS CUI [1,1])
C1442880 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
myocardial_infarction
Item
Myocardial infarction at enrollment
string
C0027051 (UMLS CUI [1,1])
C1442880 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
TC
Item
Total cholesterol
float
C1445957 (UMLS CUI [1,1])
HDL
Item
High-density lipoprotein
float
C0392885 (UMLS CUI [1,1])
LDL
Item
Low-density lipoprotein
float
C0202117 (UMLS CUI [1,1])
Triglycerides
Item
Triglycerides
float
C0202236 (UMLS CUI [1,1])
ECG_PR_int
Item
ECG - PR Interval
float
C0429087 (UMLS CUI [1,1])
ECG_QRS_int
Item
ECG - QRS Interval
float
C0429025 (UMLS CUI [1,1])
ECG_QT_int
Item
ECG - QT Interval
float
C1287082 (UMLS CUI [1,1])
ECG_ventricular_rate
Item
ECG - ventricular rate
float
C2189285 (UMLS CUI [1,1])

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