ID

45873

Description

Principal Investigator: Patrick Ellinor, MD, PhD, Massachusetts General Hospital, Boston, MA, USA MeSH: Atrial Fibrillation https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001001 The Massachusetts General Hospital (MGH) Atrial Fibrillation Study was initiated in 2001. The study has enrolled serial probands, unaffected and affected family members with atrial fibrillation. At enrollment participants undergo a structured interview to systematically capture their past medical history, AF treatments, and family history. An electrocardiogram is performed; the results of an echocardiogram are obtained; and blood samples are obtained. *The Massachusetts General Hospital (MGH) Atrial Fibrillation Study is utilized in the following dbGaP substudies.* To view genotypes, analysis, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" box located on the right hand side of this top-level study page phs001001 Massachusetts General Hospital (MGH) Atrial Fibrillation Study.- phs001116 MGH AF CHARGE-S - phs001117 MGH AF Exome Sequencing - phs001118 MGH AF Medical Resequencing

Link

dbGaP study = phs001001

Keywords

Versions (1)
  1. 10/27/23 10/27/23 - Simon Heim
Copyright Holder

Patrick Ellinor, MD, PhD, Massachusetts General Hospital, Boston, MA, USA

Uploaded on

October 27, 2023

DOI

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License

Creative Commons BY 4.0
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dbGaP phs001001 MGH Atrial Fibrillation Study

English

Eligibility Criteria

8 forms  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The subject consent data table contains subject IDs, consent group information, subject aliases, and affection status for atrial fibrillation (AF).
    3. This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use and substudy accession.
    4. This subject phenotype data table includes subject's sex, race, ethnicity, atrial fibrillation status, age of diagnosis, status at enrollment for age, height, weight, hypertension, diabetes, heart failure, and myocardial infarction. Measurements included are cholesterol (TC, HDL, LDL, and triglycerides) and echocardiogram (PR, QRS, and QT intervals).
    5. This MGH AF CHARGE-S sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    6. This MGH Exome Sequencing in Early AF sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    7. This MGH AF Resequencing sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    8. This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, and sex of subjects.
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
Probands were included if they had a history of atrial fibrillation. In participants with an extensive family history of atrial fibrillation, additional affected and unaffected family members were enrolled.
Description

Probands were included if they had a history of atrial fibrillation. In participants with an extensive family history of atrial fibrillation, additional affected and unaffected family members were enrolled.

Data type

boolean

Alias
UMLS CUI [1,1]
C1948021
UMLS CUI [1,2]
C0262926
UMLS CUI [1,3]
C0004238
UMLS CUI [2,1]
C0241889
UMLS CUI [2,2]
C0004238
UMLS CUI [2,3]
C2986417
UMLS CUI [2,4]
C0086282
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Similar models

Eligibility Criteria

8 forms
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The subject consent data table contains subject IDs, consent group information, subject aliases, and affection status for atrial fibrillation (AF).
    3. This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use and substudy accession.
    4. This subject phenotype data table includes subject's sex, race, ethnicity, atrial fibrillation status, age of diagnosis, status at enrollment for age, height, weight, hypertension, diabetes, heart failure, and myocardial infarction. Measurements included are cholesterol (TC, HDL, LDL, and triglycerides) and echocardiogram (PR, QRS, and QT intervals).
    5. This MGH AF CHARGE-S sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    6. This MGH Exome Sequencing in Early AF sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    7. This MGH AF Resequencing sample attributes table includes body site where sample was collected, analyte type, and tumor status.
    8. This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, and sex of subjects.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Probands were included if they had a history of atrial fibrillation. In participants with an extensive family history of atrial fibrillation, additional affected and unaffected family members were enrolled.
Item
Probands were included if they had a history of atrial fibrillation. In participants with an extensive family history of atrial fibrillation, additional affected and unaffected family members were enrolled.
boolean
C1948021 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
C0004238 (UMLS CUI [1,3])
C0241889 (UMLS CUI [2,1])
C0004238 (UMLS CUI [2,2])
C2986417 (UMLS CUI [2,3])
C0086282 (UMLS CUI [2,4])
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