ID
45856
Beschreibung
Principal Investigator: Sharon E. Plon, MD PhD, Baylor College of Medicine, Houston, TX, USA MeSH: Genes, Neoplasm,Brain Neoplasms,Soft tissue neoplasms,Bone Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001026 The BASIC3 (Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care) study is a National Genome Human Research Institute (NHGRI) and National Cancer Institute-funded Clinical Sequencing Exploratory Research (CSER) consortium project that focuses on prospective implementation of clinical whole exome sequencing in the pediatric oncology clinic. The primary study objective are to integrate information from CLIA-certified germline and tumor exome sequencing into the care of newly diagnosed solid tumor patients at Texas Children's Cancer Center, and to perform parallel evaluation of the impact of tumor and germline exomes on families and physicians. Blood and frozen tumor (if available) samples are collected from children undergoing surgery or biopsy of newly diagnosed solid tumors and subjected to exome sequencing in a CLIA-certified laboratory. Germline and tumor (if applicable) exome sequencing reports are generated and submitted into the electronic health record and returned to each patient/family by their primary oncologist. If specific (optional) consent is obtained, research sequencing studies (including transcriptome sequencing) are performed in addition to the clinical exome sequencing.
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Versionen (1)
- 08/10/23 08/10/23 - Simon Heim
Rechteinhaber
Sharon E. Plon, MD PhD, Baylor College of Medicine, Houston, TX, USA
Hochgeladen am
8 ottobre 2023
DOI
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Lizenz
Creative Commons BY 4.0
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dbGaP phs001026 BCM Advancing Sequencing in Childhood Cancer Care Study (BASIC3)
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, source subject ID, and affection status of children with cancer and involved in the "Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care (BASIC3) Clinical Exome Sequencing Study - Clinical Sequencing Exploratory Research Consortium" project.
- Subject ID, sample ID, sample use, sample source and source sample ID of children with cancer and involved in the "Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care (BASIC3) Clinical Exome Sequencing Study - Clinical Sequencing Exploratory Research Consortium" project.
- Subject ID, age at onset, sex, race, race as described by parent, and tumor histology according to pathology report of children with cancer and involved in the "Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care (BASIC3) Clinical Exome Sequencing Study - Clinical Sequencing Exploratory Research Consortium" project.
- Sample ID, analyte type, tumor status of sample, histological type of sample, tumor at time of diagnosis, at time of recurrence or peripheral blood, post treatment tumor, sequencing center of children with cancer and involved in the "Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care (BASIC3) Clinical Exome Sequencing Study - Clinical Sequencing Exploratory Research Consortium" project.
Ähnliche Modelle
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, subject source, source subject ID, and affection status of children with cancer and involved in the "Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care (BASIC3) Clinical Exome Sequencing Study - Clinical Sequencing Exploratory Research Consortium" project.
- Subject ID, sample ID, sample use, sample source and source sample ID of children with cancer and involved in the "Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care (BASIC3) Clinical Exome Sequencing Study - Clinical Sequencing Exploratory Research Consortium" project.
- Subject ID, age at onset, sex, race, race as described by parent, and tumor histology according to pathology report of children with cancer and involved in the "Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care (BASIC3) Clinical Exome Sequencing Study - Clinical Sequencing Exploratory Research Consortium" project.
- Sample ID, analyte type, tumor status of sample, histological type of sample, tumor at time of diagnosis, at time of recurrence or peripheral blood, post treatment tumor, sequencing center of children with cancer and involved in the "Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care (BASIC3) Clinical Exome Sequencing Study - Clinical Sequencing Exploratory Research Consortium" project.
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