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ID
45827
Description
Principal Investigator: Christine M. Albert, MD, MPH, Brigham and Women's Hospital, Boston, MA, USA MeSH: Atrial Fibrillation https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001040 The Women's Genome Health Study (WGHS) is a prospective cohort comprised of over 25,000 initially healthy female health professionals enrolled in the Women's Health Study, which began in 1992-1994. All participants in WGHS provided baseline blood samples and extensive survey data. Women who reported atrial fibrillation during the course of the study were asked to report diagnoses of AF at baseline, 48 months, and then annually thereafter. Participants enrolled in the continued observational follow-up who reported an incident AF event on at least one yearly questionnaire were sent an additional questionnaire to confirm the episode and to collect additional information. They were also asked for permission to review their medical records, particularly available ECGs, rhythm strips, 24-hour ECGs, and information on cardiac structure and function. For all deceased participants who reported AF during the trial and extended follow-up period, family members were contacted to obtain consent and additional relevant information. An end-point committee of physicians reviewed medical records for reported events according to predefined criteria. An incident AF event was confirmed if there was ECG evidence of AF or if a medical report clearly indicated a personal history of AF. The earliest date in the medical records when documentation was believed to have occurred was set as the date of onset of AF.
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Versions (1)
- 7/29/23 7/29/23 - Simon Heim
Copyright Holder
Christine M. Albert, MD, MPH, Brigham and Women's Hospital, Boston, MA, USA
Uploaded on
July 29, 2023
DOI
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License
Creative Commons BY 4.0
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dbGaP phs001040 NHLBI TOPMed: Novel Risk Factors for the Development of Atrial Fibrillation in Women
This subject phenotype data table includes subject's sex, race, atrial fibrillation (AF) status, age at enrollment, age at AF diagnosis, and cholesterol measurements (n=6 variables; LDL, HDL, triglycerides, total cholesterol and cholesterol lowering medication at baseline, and blood draw following 8 hr fast). Additional variables have been added: height, weight, BMI, waist/hip ratio, diabetes at baseline, age at menarche, uterine fibroids, age at menopause, diastolic and systolic blood pressure, blood test (n=9 variables; APOA1, APOB, creatinine, CRP, fibrinogen, HBA1C, homocysteine, ICAM, and LPA), principal components (n=10 variables), alcohol use, excercise, and smoking status.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs, consent group information, subject aliases, and affection status for atrial fibrillation (AF).
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This sample attributes table includes body site where sample was collected, analyte type, tumor status, sequencing center, funding source, TOPMed phase, project, and study name.
- This subject phenotype data table includes subject's sex, race, atrial fibrillation (AF) status, age at enrollment, age at AF diagnosis, and cholesterol measurements (n=6 variables; LDL, HDL, triglycerides, total cholesterol and cholesterol lowering medication at baseline, and blood draw following 8 hr fast). Additional variables have been added: height, weight, BMI, waist/hip ratio, diabetes at baseline, age at menarche, uterine fibroids, age at menopause, diastolic and systolic blood pressure, blood test (n=9 variables; APOA1, APOB, creatinine, CRP, fibrinogen, HBA1C, homocysteine, ICAM, and LPA), principal components (n=10 variables), alcohol use, excercise, and smoking status.
Similar models
This subject phenotype data table includes subject's sex, race, atrial fibrillation (AF) status, age at enrollment, age at AF diagnosis, and cholesterol measurements (n=6 variables; LDL, HDL, triglycerides, total cholesterol and cholesterol lowering medication at baseline, and blood draw following 8 hr fast). Additional variables have been added: height, weight, BMI, waist/hip ratio, diabetes at baseline, age at menarche, uterine fibroids, age at menopause, diastolic and systolic blood pressure, blood test (n=9 variables; APOA1, APOB, creatinine, CRP, fibrinogen, HBA1C, homocysteine, ICAM, and LPA), principal components (n=10 variables), alcohol use, excercise, and smoking status.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs, consent group information, subject aliases, and affection status for atrial fibrillation (AF).
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This sample attributes table includes body site where sample was collected, analyte type, tumor status, sequencing center, funding source, TOPMed phase, project, and study name.
- This subject phenotype data table includes subject's sex, race, atrial fibrillation (AF) status, age at enrollment, age at AF diagnosis, and cholesterol measurements (n=6 variables; LDL, HDL, triglycerides, total cholesterol and cholesterol lowering medication at baseline, and blood draw following 8 hr fast). Additional variables have been added: height, weight, BMI, waist/hip ratio, diabetes at baseline, age at menarche, uterine fibroids, age at menopause, diastolic and systolic blood pressure, blood test (n=9 variables; APOA1, APOB, creatinine, CRP, fibrinogen, HBA1C, homocysteine, ICAM, and LPA), principal components (n=10 variables), alcohol use, excercise, and smoking status.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
De-identified Subject ID
Item
De-identified Subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
C2348585 (UMLS CUI [1,2])
AF status
Item
AF status
string
C0004238 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
C0449438 (UMLS CUI [1,2])
Age at enrollment
Item
Age at enrollment
float
C5236162 (UMLS CUI [1,1])
Age at AF diagnosis
Item
Age at AF diagnosis
float
C1828181 (UMLS CUI [1,1])
C0004238 (UMLS CUI [1,2])
C0004238 (UMLS CUI [1,2])
Gender of participant
Item
Gender of participant
string
C0079399 (UMLS CUI [1,1])
Race of participant
Item
Race of participant
string
C0034510 (UMLS CUI [1,1])
LDL cholesterol in mg/dl at baseline, direct measure
Item
LDL cholesterol in mg/dl at baseline, direct measure
float
C0428474 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
HDL cholesterol in mg/dl at baseline
Item
HDL cholesterol in mg/dl at baseline
float
C0428472 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
Triglycerides in mg/dl at baseline
Item
Triglycerides in mg/dl at baseline
float
C0202236 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
Total cholesterol at baseline
Item
Total cholesterol at baseline
float
C1445957 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
Item
Baseline blood draw at least 8 hours after last meal
text
C1442488 (UMLS CUI [1,1])
C0190979 (UMLS CUI [1,2])
C2708683 (UMLS CUI [1,3])
C0190979 (UMLS CUI [1,2])
C2708683 (UMLS CUI [1,3])
CL Item
no (0)
CL Item
yes (1)
Item
Cholesterol lowering medication at baseline
text
C0003277 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
C0013227 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
CL Item
no (0)
CL Item
yes (1)
Apo A1
Item
Apo A1
float
C2698168 (UMLS CUI [1,1])
Apo B
Item
Apo B
float
C0003593 (UMLS CUI [1,1])
Body mass index
Item
Body mass index
float
C1305855 (UMLS CUI [1,1])
Creatinine
Item
Creatinine
float
C0201976 (UMLS CUI [1,1])
CRP(Denka)
Item
CRP(Denka)
float
C0201657 (UMLS CUI [1,1])
CL Item
<65 (1)
CL Item
65-74 (2)
CL Item
75-84 (3)
CL Item
85-89 (4)
CL Item
90-94 (5)
CL Item
95-104 (6)
CL Item
105+ (7)
CL Item
rarely/never (1)
CL Item
1-3 drinks/month (2)
CL Item
1-6 drinks/week (3)
CL Item
1+ drinks/day (4)
Fibrinogen
Item
Fibrinogen
float
C0337428 (UMLS CUI [1,1])
HbA1c
Item
HbA1c
float
C0019018 (UMLS CUI [1,1])
Height
Item
Height
float
C0005890 (UMLS CUI [1,1])
Homocysteine
Item
Homocysteine
float
C2242817 (UMLS CUI [1,1])
ICAM
Item
ICAM
float
C4084871 (UMLS CUI [1,1])
Lp(a)
Item
Lp(a)
float
C0065058 (UMLS CUI [1,1])
CL Item
rarely/never (1)
CL Item
<1 time/week (2)
CL Item
1 time/week (3)
CL Item
2-3 times/week (4)
CL Item
4-6 times/week (5)
CL Item
7+ times/week (6)
CL Item
<110 (1)
CL Item
110-119 (2)
CL Item
120-129 (3)
CL Item
130-139 (4)
CL Item
140-149 (5)
CL Item
150-159 (6)
CL Item
160-169 (7)
CL Item
170-179 (8)
CL Item
180+ (9)
CL Item
current smoker (1)
CL Item
past smoker (2)
CL Item
never smoked (3)
WEIGHT
Item
Weight
float
C0005910 (UMLS CUI [1,1])
CL Item
no (0)
CL Item
yes (1)
CL Item
no (0)
CL Item
yes (1)
Age at menarche
Item
Age at menarche
float
C1314691 (UMLS CUI [1,1])
CL Item
no (0)
CL Item
yes (1)
Principal component 1
Item
Principal component 1
float
C1882460 (UMLS CUI [1,1])
Principal component 2
Item
Principal component 2
float
C1882460 (UMLS CUI [1,1])
Principal component 3
Item
Principal component 3
float
C1882460 (UMLS CUI [1,1])
Principal component 4
Item
Principal component 4
float
C1882460 (UMLS CUI [1,1])
Principal component 5
Item
Principal component 5
float
C1882460 (UMLS CUI [1,1])
Principal component 6
Item
Principal component 6
float
C1882460 (UMLS CUI [1,1])
Principal component 7
Item
Principal component 7
float
C1882460 (UMLS CUI [1,1])
Principal component 8
Item
Principal component 8
float
C1882460 (UMLS CUI [1,1])
Principal component 9
Item
Principal component 9
float
C1882460 (UMLS CUI [1,1])
Principal component 10
Item
Principal component 10
float
C1882460 (UMLS CUI [1,1])
Age at menopause
Item
Age at menopause
float
C1629609 (UMLS CUI [1,1])
Waist/hip ratio
Item
Waist/hip ratio
float
C0205682 (UMLS CUI [1,1])
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