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ID
45816
Beschrijving
Principal Investigator: Carole Ober, PhD, University of Chicago, Chicago, IL, USA MeSH: Fertility,Infertility, Female,Time-to-Pregnancy https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001146 We performed an unbiased genome-wide expression quantitative trait locus (eQTL) mapping study to identify common regulatory (expression) single nucleotide polymorphisms (eSNPs) in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle. Biopsies were collected from 58 women with two or more early pregnancy losses and 53 of these samples passed all quality control. RNA was extracted from endometrial biopsies and DNA was extracted for sequencing from blood. Gene expression data can be found at NCBI GEO Series GSE77688.
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- 29-06-23 29-06-23 - Simon Heim
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Carole Ober, PhD, University of Chicago, Chicago, IL, USA
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29 juni 2023
DOI
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Creative Commons BY 4.0
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dbGaP phs001146 eQTL Mapping of Mid-Secretory Phase Endometrial Cells
Sample ID, genotyping center, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Subject ID, sample ID, and sample use variable obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Subject ID, age, BMI, race, number of previous miscarriages at time of endometrial biopsy, and time of year of endometrial biopsy of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Sample ID, genotyping center, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
Similar models
Sample ID, genotyping center, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Subject ID, sample ID, and sample use variable obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Subject ID, age, BMI, race, number of previous miscarriages at time of endometrial biopsy, and time of year of endometrial biopsy of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Sample ID, genotyping center, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
SAMPLE_ID
Item
De-identified sample ID
text
C4684638 (UMLS CUI [1,1])
C1299222 (UMLS CUI [1,2])
C1299222 (UMLS CUI [1,2])
GENOTYPING_CENTER
Item
Name of the center which conducted genotyping [UCSF]
text
C1301943 (UMLS CUI [1,1])
C5575037 (UMLS CUI [1,2])
C1285573 (UMLS CUI [1,3])
C5575037 (UMLS CUI [1,2])
C1285573 (UMLS CUI [1,3])
BODY_SITE
Item
Body site where sample was obtained
text
C1515974 (UMLS CUI [1,1])
C1285573 (UMLS CUI [1,2])
C1285573 (UMLS CUI [1,2])
ANALYTE_TYPE
Item
Analyte type
text
C4744818 (UMLS CUI [1,1])
CL Item
Not a tumor (N)