ID
45816
Descrição
Principal Investigator: Carole Ober, PhD, University of Chicago, Chicago, IL, USA MeSH: Fertility,Infertility, Female,Time-to-Pregnancy https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001146 We performed an unbiased genome-wide expression quantitative trait locus (eQTL) mapping study to identify common regulatory (expression) single nucleotide polymorphisms (eSNPs) in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle. Biopsies were collected from 58 women with two or more early pregnancy losses and 53 of these samples passed all quality control. RNA was extracted from endometrial biopsies and DNA was extracted for sequencing from blood. Gene expression data can be found at NCBI GEO Series GSE77688.
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- 29/06/2023 29/06/2023 - Simon Heim
Titular dos direitos
Carole Ober, PhD, University of Chicago, Chicago, IL, USA
Transferido a
29 de junho de 2023
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs001146 eQTL Mapping of Mid-Secretory Phase Endometrial Cells
Subject ID and consent group of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Subject ID, sample ID, and sample use variable obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Subject ID, age, BMI, race, number of previous miscarriages at time of endometrial biopsy, and time of year of endometrial biopsy of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Sample ID, genotyping center, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
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Subject ID and consent group of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Subject ID, sample ID, and sample use variable obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Subject ID, age, BMI, race, number of previous miscarriages at time of endometrial biopsy, and time of year of endometrial biopsy of participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
- Sample ID, genotyping center, body site where sample was obtained, analyte type, and tumor status of samples obtained from participants in mid-secretory endometrium, corresponding to the luteal phase of the ovarian cycle and involved in the "Expression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes" project.
C0441833 (UMLS CUI [1,2])
C0242481 (UMLS CUI [1,2])
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