ID

45798

Description

Principal Investigator: MeSH: Stunting,Growth Disorders,Malnutrition,Epigenomics,Virus Diseases,Parasitic Diseases,Digestive System Diseases,Respiratory Tract Diseases,Nervous System Diseases,Nutritional and Metabolic Diseases,Immune System Diseases,Disorders of Environmental Origin https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001073 The PROVIDE study (Dhaka, Bangladesh) is a randomized clinical trial platform which evaluated the efficacy of delayed-dose oral rotavirus vaccine as well as the benefit of an injectable polio vaccine replacing one dose of oral polio vaccine. This rigorous infrastructure supported the additional examination of hypotheses of vaccine underperformance. Primary and secondary efficacy and immunogenicity measures for rotavirus and polio vaccines were measured, as well as the impact of maternal and childhood malnutrition, environmental enteropathy, and additional exploratory variables. This study has been conducted to test the role of epigenetics in malnutrition, specifically the genome-wide role of histone modifications, which are known to provide a precise signature of metabolic state and immune system function.

Link

dbGaP-study=phs001073

Keywords

Versions (1)
  1. 6/23/23 6/23/23 - Chiara Middel
Copyright Holder

David Auble, Ph.D. Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA, USA; William Petri, M.D., Ph.D. Division of Infectious Diseases and International Health, University of Virginia Health Systema, Charlottesville, VA, USA; Rashidul Haque, M.B., Ph.D. International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Uploaded on

June 23, 2023

DOI

To request one please log in.

License

Creative Commons BY 4.0
Model comments :

You can comment on the data model here. Via the speech bubbles at the itemgroups and items you can add comments to those specificially.

Back to model comments
Itemgroup comments for :

Item comments for :

In order to download data models you must be logged in. Please log in or register for free.

dbGaP phs001073 Epigenetic Analysis of Malnutrition

English

This subject phenotypes data table includes subject's sex, age at sample draw, gender, height and weight measurements at various weeks (n=8 variables), BMI, biomarkers at various weeks (n=10 variables; vitamin D, retinol binding protein, ferritin, zinc, C-reactive protein, CD14, Reg1B, and IL-6), and status of malnutrition.

6 forms  
pht005955
Description

pht005955

Alias
UMLS CUI [1,1]
C3846158
De-identified Subject ID
Description

SUBJECT_ID

Data type

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
When samples were drawn in weeks of age
Description

age_sample_draw

Data type

text

Measurement units
  • Weeks
Alias
UMLS CUI [1,1]
C0439230
UMLS CUI [1,2]
C0001779
UMLS CUI [1,3]
C0011008
UMLS CUI [1,4]
C0200345
Weeks
Gender of subject
Description

gender

Data type

string

Alias
UMLS CUI [1,1]
C0079399
Status at 53 weeks of age
Description

Status__at_53_weeks

Data type

string

Alias
UMLS CUI [1,1]
C0449438
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
Height for age z score at 18 weeks of age
Description

haz_wk18

Data type

float

Alias
UMLS CUI [1,1]
C0005890
UMLS CUI [1,2]
C0871421
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
Height for age z score at 52 weeks of age
Description

haz_wk52

Data type

float

Alias
UMLS CUI [1,1]
C0005890
UMLS CUI [1,2]
C0871421
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
Change in (delta) Height for age z score at 52 weeks of age
Description

Delta_HAZ_wk52

Data type

float

Alias
UMLS CUI [1,1]
C0443172
UMLS CUI [1,2]
C0005890
UMLS CUI [1,3]
C0871421
UMLS CUI [1,4]
C0001779
UMLS CUI [1,5]
C0439230
Weight for age z score at 18 weeks of age
Description

waz_wk18

Data type

float

Alias
UMLS CUI [1,1]
C0005910
UMLS CUI [1,2]
C0871421
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
Weight for age z score at 52 weeks of age
Description

waz_wk52

Data type

float

Alias
UMLS CUI [1,1]
C0005910
UMLS CUI [1,2]
C0871421
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
Change in (delta) weight for age z score at 52 weeks of age
Description

Delta_WAZ_wk52

Data type

float

Alias
UMLS CUI [1,1]
C0443172
UMLS CUI [1,2]
C0005910
UMLS CUI [1,3]
C0871421
UMLS CUI [1,4]
C0001779
UMLS CUI [1,5]
C0439230
Height of individual (mother)
Description

height

Data type

float

Measurement units
  • Centimeters
Alias
UMLS CUI [1,1]
C0005890
UMLS CUI [1,2]
C0026591
Centimeters
Body mass index of individual (wt in kg/ht in meter 2; mother)
Description

BMI

Data type

float

Measurement units
  • kg/m2
Alias
UMLS CUI [1,1]
C1305855
UMLS CUI [1,2]
C0026591
kg/m2
Weight of individual (mother)
Description

weight

Data type

float

Measurement units
  • Kilograms
Alias
UMLS CUI [1,1]
C0005910
UMLS CUI [1,2]
C0026591
Kilograms
Vitamin D at 6 weeks of age
Description

vitd_wk6

Data type

text

Measurement units
  • d nmol/L
Alias
UMLS CUI [1,1]
C0919758
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
d nmol/L
Vitamin D at 18 weeks of age
Description

vitd_18wk

Data type

float

Measurement units
  • d nmol/L
Alias
UMLS CUI [1,1]
C0919758
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
d nmol/L
Retinol binding protein at 6 weeks of age
Description

rbp_wk6

Data type

float

Measurement units
  • ng/mL
Alias
UMLS CUI [1,1]
C1446172
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
ng/mL
Ferritin at 6 weeks of age
Description

fer_wk18

Data type

float

Measurement units
  • ng/mL
Alias
UMLS CUI [1,1]
C0015879
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
ng/mL
Zinc at 6 weeks of age
Description

zn_wk6

Data type

float

Measurement units
  • ug/L
Alias
UMLS CUI [1,1]
C0373748
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
ug/L
C-reactive protein at 6 weeks of age
Description

crp_wk6

Data type

float

Measurement units
  • mg/L
Alias
UMLS CUI [1,1]
C0006560
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
mg/L
C-reactive protein at 18 weeks of age
Description

crp_wk18

Data type

float

Measurement units
  • mg/L
Alias
UMLS CUI [1,1]
C0006560
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0008972
UMLS CUI [1,5]
C0439230
mg/L
Soluble CD14 at 6 weeks of age
Description

sCD14_wk6

Data type

text

Measurement units
  • pg/mL
Alias
UMLS CUI [1,1]
C1948047
UMLS CUI [1,2]
C0108768
UMLS CUI [1,3]
C0011008
UMLS CUI [1,4]
C0001779
UMLS CUI [1,5]
C0439230
pg/mL
Reg1B at 12 weeks of age
Description

Reg1B_wk12

Data type

float

Measurement units
  • ug/mL
Alias
UMLS CUI [1,1]
C1307266
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
ug/mL
IL-6 at 18 weeks of age
Description

IL-6_wk18

Data type

float

Measurement units
  • pg/mL
Alias
UMLS CUI [1,1]
C0919829
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0439230
pg/mL
Back to the top of the page

Similar models

This subject phenotypes data table includes subject's sex, age at sample draw, gender, height and weight measurements at various weeks (n=8 variables), BMI, biomarkers at various weeks (n=10 variables; vitamin D, retinol binding protein, ferritin, zinc, C-reactive protein, CD14, Reg1B, and IL-6), and status of malnutrition.

6 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
pht005955
C3846158 (UMLS CUI [1,1])
SUBJECT_ID
Item
De-identified Subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
age_sample_draw
Item
When samples were drawn in weeks of age
text
C0439230 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,3])
C0200345 (UMLS CUI [1,4])
gender
Item
Gender of subject
string
C0079399 (UMLS CUI [1,1])
Item
Status at 53 weeks of age
string
C0449438 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
Status__at_53_weeks
Code List
Status at 53 weeks of age
CL Item
Malnourished (Mal)
haz_wk18
Item
Height for age z score at 18 weeks of age
float
C0005890 (UMLS CUI [1,1])
C0871421 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
haz_wk52
Item
Height for age z score at 52 weeks of age
float
C0005890 (UMLS CUI [1,1])
C0871421 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
Delta_HAZ_wk52
Item
Change in (delta) Height for age z score at 52 weeks of age
float
C0443172 (UMLS CUI [1,1])
C0005890 (UMLS CUI [1,2])
C0871421 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0439230 (UMLS CUI [1,5])
waz_wk18
Item
Weight for age z score at 18 weeks of age
float
C0005910 (UMLS CUI [1,1])
C0871421 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
waz_wk52
Item
Weight for age z score at 52 weeks of age
float
C0005910 (UMLS CUI [1,1])
C0871421 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
Delta_WAZ_wk52
Item
Change in (delta) weight for age z score at 52 weeks of age
float
C0443172 (UMLS CUI [1,1])
C0005910 (UMLS CUI [1,2])
C0871421 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0439230 (UMLS CUI [1,5])
height
Item
Height of individual (mother)
float
C0005890 (UMLS CUI [1,1])
C0026591 (UMLS CUI [1,2])
BMI
Item
Body mass index of individual (wt in kg/ht in meter 2; mother)
float
C1305855 (UMLS CUI [1,1])
C0026591 (UMLS CUI [1,2])
weight
Item
Weight of individual (mother)
float
C0005910 (UMLS CUI [1,1])
C0026591 (UMLS CUI [1,2])
vitd_wk6
Item
Vitamin D at 6 weeks of age
text
C0919758 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
vitd_18wk
Item
Vitamin D at 18 weeks of age
float
C0919758 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
rbp_wk6
Item
Retinol binding protein at 6 weeks of age
float
C1446172 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
fer_wk18
Item
Ferritin at 6 weeks of age
float
C0015879 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
zn_wk6
Item
Zinc at 6 weeks of age
float
C0373748 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
crp_wk6
Item
C-reactive protein at 6 weeks of age
float
C0006560 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
crp_wk18
Item
C-reactive protein at 18 weeks of age
float
C0006560 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0008972 (UMLS CUI [1,4])
C0439230 (UMLS CUI [1,5])
sCD14_wk6
Item
Soluble CD14 at 6 weeks of age
text
C1948047 (UMLS CUI [1,1])
C0108768 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0439230 (UMLS CUI [1,5])
Reg1B_wk12
Item
Reg1B at 12 weeks of age
float
C1307266 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
IL-6_wk18
Item
IL-6 at 18 weeks of age
float
C0919829 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])
Back to the top of the page 

Contact

Please use this form for feedback, questions and suggestions for improvements.

Fields marked with * are required.

Help

Do you need help on how to use the search function? Please watch the corresponding tutorial video for more details and learn how to use the search function most efficiently.

Watch Tutorial