0 Ratings
ID

45798

Description

Principal Investigator: MeSH: Stunting,Growth Disorders,Malnutrition,Epigenomics,Virus Diseases,Parasitic Diseases,Digestive System Diseases,Respiratory Tract Diseases,Nervous System Diseases,Nutritional and Metabolic Diseases,Immune System Diseases,Disorders of Environmental Origin https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001073 The PROVIDE study (Dhaka, Bangladesh) is a randomized clinical trial platform which evaluated the efficacy of delayed-dose oral rotavirus vaccine as well as the benefit of an injectable polio vaccine replacing one dose of oral polio vaccine. This rigorous infrastructure supported the additional examination of hypotheses of vaccine underperformance. Primary and secondary efficacy and immunogenicity measures for rotavirus and polio vaccines were measured, as well as the impact of maternal and childhood malnutrition, environmental enteropathy, and additional exploratory variables. This study has been conducted to test the role of epigenetics in malnutrition, specifically the genome-wide role of histone modifications, which are known to provide a precise signature of metabolic state and immune system function.

Link

dbGaP-study=phs001073

Keywords

Versions (1)
  1. 23/06/23 23/06/23 - Chiara Middel
Copyright Holder

David Auble, Ph.D. Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA, USA; William Petri, M.D., Ph.D. Division of Infectious Diseases and International Health, University of Virginia Health Systema, Charlottesville, VA, USA; Rashidul Haque, M.B., Ph.D. International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Uploaded on

23 giugno 2023

DOI

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License

Creative Commons BY 4.0
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    dbGaP phs001073 Epigenetic Analysis of Malnutrition

    English

    This subject phenotypes data table includes subject's sex, age at sample draw, gender, height and weight measurements at various weeks (n=8 variables), BMI, biomarkers at various weeks (n=10 variables; vitamin D, retinol binding protein, ferritin, zinc, C-reactive protein, CD14, Reg1B, and IL-6), and status of malnutrition.

    6 forms  
    pht005955
    Description

    pht005955

    Alias
    UMLS CUI [1,1]
    C3846158
    De-identified Subject ID
    Description

    SUBJECT_ID

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C4684638
    UMLS CUI [1,2]
    C2348585
    When samples were drawn in weeks of age
    Description

    age_sample_draw

    Data type

    text

    Measurement units
    • Weeks
    Alias
    UMLS CUI [1,1]
    C0439230
    UMLS CUI [1,2]
    C0001779
    UMLS CUI [1,3]
    C0011008
    UMLS CUI [1,4]
    C0200345
    Weeks
    Gender of subject
    Description

    gender

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0079399
    Status at 53 weeks of age
    Description

    Status__at_53_weeks

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0449438
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    Height for age z score at 18 weeks of age
    Description

    haz_wk18

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C0005890
    UMLS CUI [1,2]
    C0871421
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    Height for age z score at 52 weeks of age
    Description

    haz_wk52

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C0005890
    UMLS CUI [1,2]
    C0871421
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    Change in (delta) Height for age z score at 52 weeks of age
    Description

    Delta_HAZ_wk52

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C0443172
    UMLS CUI [1,2]
    C0005890
    UMLS CUI [1,3]
    C0871421
    UMLS CUI [1,4]
    C0001779
    UMLS CUI [1,5]
    C0439230
    Weight for age z score at 18 weeks of age
    Description

    waz_wk18

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C0005910
    UMLS CUI [1,2]
    C0871421
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    Weight for age z score at 52 weeks of age
    Description

    waz_wk52

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C0005910
    UMLS CUI [1,2]
    C0871421
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    Change in (delta) weight for age z score at 52 weeks of age
    Description

    Delta_WAZ_wk52

    Data type

    float

    Alias
    UMLS CUI [1,1]
    C0443172
    UMLS CUI [1,2]
    C0005910
    UMLS CUI [1,3]
    C0871421
    UMLS CUI [1,4]
    C0001779
    UMLS CUI [1,5]
    C0439230
    Height of individual (mother)
    Description

    height

    Data type

    float

    Measurement units
    • Centimeters
    Alias
    UMLS CUI [1,1]
    C0005890
    UMLS CUI [1,2]
    C0026591
    Centimeters
    Body mass index of individual (wt in kg/ht in meter 2; mother)
    Description

    BMI

    Data type

    float

    Measurement units
    • kg/m2
    Alias
    UMLS CUI [1,1]
    C1305855
    UMLS CUI [1,2]
    C0026591
    kg/m2
    Weight of individual (mother)
    Description

    weight

    Data type

    float

    Measurement units
    • Kilograms
    Alias
    UMLS CUI [1,1]
    C0005910
    UMLS CUI [1,2]
    C0026591
    Kilograms
    Vitamin D at 6 weeks of age
    Description

    vitd_wk6

    Data type

    text

    Measurement units
    • d nmol/L
    Alias
    UMLS CUI [1,1]
    C0919758
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    d nmol/L
    Vitamin D at 18 weeks of age
    Description

    vitd_18wk

    Data type

    float

    Measurement units
    • d nmol/L
    Alias
    UMLS CUI [1,1]
    C0919758
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    d nmol/L
    Retinol binding protein at 6 weeks of age
    Description

    rbp_wk6

    Data type

    float

    Measurement units
    • ng/mL
    Alias
    UMLS CUI [1,1]
    C1446172
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    ng/mL
    Ferritin at 6 weeks of age
    Description

    fer_wk18

    Data type

    float

    Measurement units
    • ng/mL
    Alias
    UMLS CUI [1,1]
    C0015879
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    ng/mL
    Zinc at 6 weeks of age
    Description

    zn_wk6

    Data type

    float

    Measurement units
    • ug/L
    Alias
    UMLS CUI [1,1]
    C0373748
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    ug/L
    C-reactive protein at 6 weeks of age
    Description

    crp_wk6

    Data type

    float

    Measurement units
    • mg/L
    Alias
    UMLS CUI [1,1]
    C0006560
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    mg/L
    C-reactive protein at 18 weeks of age
    Description

    crp_wk18

    Data type

    float

    Measurement units
    • mg/L
    Alias
    UMLS CUI [1,1]
    C0006560
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0008972
    UMLS CUI [1,5]
    C0439230
    mg/L
    Soluble CD14 at 6 weeks of age
    Description

    sCD14_wk6

    Data type

    text

    Measurement units
    • pg/mL
    Alias
    UMLS CUI [1,1]
    C1948047
    UMLS CUI [1,2]
    C0108768
    UMLS CUI [1,3]
    C0011008
    UMLS CUI [1,4]
    C0001779
    UMLS CUI [1,5]
    C0439230
    pg/mL
    Reg1B at 12 weeks of age
    Description

    Reg1B_wk12

    Data type

    float

    Measurement units
    • ug/mL
    Alias
    UMLS CUI [1,1]
    C1307266
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    ug/mL
    IL-6 at 18 weeks of age
    Description

    IL-6_wk18

    Data type

    float

    Measurement units
    • pg/mL
    Alias
    UMLS CUI [1,1]
    C0919829
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [1,4]
    C0439230
    pg/mL
    Back to the top of the page

    Similar models

    This subject phenotypes data table includes subject's sex, age at sample draw, gender, height and weight measurements at various weeks (n=8 variables), BMI, biomarkers at various weeks (n=10 variables; vitamin D, retinol binding protein, ferritin, zinc, C-reactive protein, CD14, Reg1B, and IL-6), and status of malnutrition.

    6 forms
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    pht005955
    C3846158 (UMLS CUI [1,1])
    SUBJECT_ID
    Item
    De-identified Subject ID
    string
    C4684638 (UMLS CUI [1,1])
    C2348585 (UMLS CUI [1,2])
    age_sample_draw
    Item
    When samples were drawn in weeks of age
    text
    C0439230 (UMLS CUI [1,1])
    C0001779 (UMLS CUI [1,2])
    C0011008 (UMLS CUI [1,3])
    C0200345 (UMLS CUI [1,4])
    gender
    Item
    Gender of subject
    string
    C0079399 (UMLS CUI [1,1])
    Item
    Status at 53 weeks of age
    string
    C0449438 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    Status__at_53_weeks
    Code List
    Status at 53 weeks of age
    CL Item
    Malnourished (Mal)
    haz_wk18
    Item
    Height for age z score at 18 weeks of age
    float
    C0005890 (UMLS CUI [1,1])
    C0871421 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    haz_wk52
    Item
    Height for age z score at 52 weeks of age
    float
    C0005890 (UMLS CUI [1,1])
    C0871421 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    Delta_HAZ_wk52
    Item
    Change in (delta) Height for age z score at 52 weeks of age
    float
    C0443172 (UMLS CUI [1,1])
    C0005890 (UMLS CUI [1,2])
    C0871421 (UMLS CUI [1,3])
    C0001779 (UMLS CUI [1,4])
    C0439230 (UMLS CUI [1,5])
    waz_wk18
    Item
    Weight for age z score at 18 weeks of age
    float
    C0005910 (UMLS CUI [1,1])
    C0871421 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    waz_wk52
    Item
    Weight for age z score at 52 weeks of age
    float
    C0005910 (UMLS CUI [1,1])
    C0871421 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    Delta_WAZ_wk52
    Item
    Change in (delta) weight for age z score at 52 weeks of age
    float
    C0443172 (UMLS CUI [1,1])
    C0005910 (UMLS CUI [1,2])
    C0871421 (UMLS CUI [1,3])
    C0001779 (UMLS CUI [1,4])
    C0439230 (UMLS CUI [1,5])
    height
    Item
    Height of individual (mother)
    float
    C0005890 (UMLS CUI [1,1])
    C0026591 (UMLS CUI [1,2])
    BMI
    Item
    Body mass index of individual (wt in kg/ht in meter 2; mother)
    float
    C1305855 (UMLS CUI [1,1])
    C0026591 (UMLS CUI [1,2])
    weight
    Item
    Weight of individual (mother)
    float
    C0005910 (UMLS CUI [1,1])
    C0026591 (UMLS CUI [1,2])
    vitd_wk6
    Item
    Vitamin D at 6 weeks of age
    text
    C0919758 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    vitd_18wk
    Item
    Vitamin D at 18 weeks of age
    float
    C0919758 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    rbp_wk6
    Item
    Retinol binding protein at 6 weeks of age
    float
    C1446172 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    fer_wk18
    Item
    Ferritin at 6 weeks of age
    float
    C0015879 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    zn_wk6
    Item
    Zinc at 6 weeks of age
    float
    C0373748 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    crp_wk6
    Item
    C-reactive protein at 6 weeks of age
    float
    C0006560 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    crp_wk18
    Item
    C-reactive protein at 18 weeks of age
    float
    C0006560 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0008972 (UMLS CUI [1,4])
    C0439230 (UMLS CUI [1,5])
    sCD14_wk6
    Item
    Soluble CD14 at 6 weeks of age
    text
    C1948047 (UMLS CUI [1,1])
    C0108768 (UMLS CUI [1,2])
    C0011008 (UMLS CUI [1,3])
    C0001779 (UMLS CUI [1,4])
    C0439230 (UMLS CUI [1,5])
    Reg1B_wk12
    Item
    Reg1B at 12 weeks of age
    float
    C1307266 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    IL-6_wk18
    Item
    IL-6 at 18 weeks of age
    float
    C0919829 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0439230 (UMLS CUI [1,4])
    Back to the top of the page 

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