ID
45798
Description
Principal Investigator: MeSH: Stunting,Growth Disorders,Malnutrition,Epigenomics,Virus Diseases,Parasitic Diseases,Digestive System Diseases,Respiratory Tract Diseases,Nervous System Diseases,Nutritional and Metabolic Diseases,Immune System Diseases,Disorders of Environmental Origin https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001073 The PROVIDE study (Dhaka, Bangladesh) is a randomized clinical trial platform which evaluated the efficacy of delayed-dose oral rotavirus vaccine as well as the benefit of an injectable polio vaccine replacing one dose of oral polio vaccine. This rigorous infrastructure supported the additional examination of hypotheses of vaccine underperformance. Primary and secondary efficacy and immunogenicity measures for rotavirus and polio vaccines were measured, as well as the impact of maternal and childhood malnutrition, environmental enteropathy, and additional exploratory variables. This study has been conducted to test the role of epigenetics in malnutrition, specifically the genome-wide role of histone modifications, which are known to provide a precise signature of metabolic state and immune system function.
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Versions (1)
- 6/23/23 6/23/23 - Chiara Middel
Copyright Holder
David Auble, Ph.D. Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA, USA; William Petri, M.D., Ph.D. Division of Infectious Diseases and International Health, University of Virginia Health Systema, Charlottesville, VA, USA; Rashidul Haque, M.B., Ph.D. International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Uploaded on
June 23, 2023
DOI
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License
Creative Commons BY 4.0
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dbGaP phs001073 Epigenetic Analysis of Malnutrition
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs, consent group information, subject aliases, and affection status for malnutrition.
- This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, and sex of subjects.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotypes data table includes subject's sex, age at sample draw, gender, height and weight measurements at various weeks (n=8 variables), BMI, biomarkers at various weeks (n=10 variables; vitamin D, retinol binding protein, ferritin, zinc, C-reactive protein, CD14, Reg1B, and IL-6), and status of malnutrition.
- This sample attributes table includes body site where sample was collected, analyte type, histological type, sequencing center, blood collection interval, and histone mark used.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs, consent group information, subject aliases, and affection status for malnutrition.
- This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, and sex of subjects.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotypes data table includes subject's sex, age at sample draw, gender, height and weight measurements at various weeks (n=8 variables), BMI, biomarkers at various weeks (n=10 variables; vitamin D, retinol binding protein, ferritin, zinc, C-reactive protein, CD14, Reg1B, and IL-6), and status of malnutrition.
- This sample attributes table includes body site where sample was collected, analyte type, histological type, sequencing center, blood collection interval, and histone mark used.
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C0162429 (UMLS CUI [2,5])
C0517226 (UMLS CUI [2,6])
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