ID
45794
Description
Principal Investigator: David Hafler, Yale School of Medicine, New Haven, CT, USA MeSH: Glioblastoma,Programmed Cell Death 1 Receptor https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001079 PD-1 is an important immune checkpoint inhibitor that shows great promise in the clinic, particularly for melanoma and lung cancers. Since PD-1 is also expressed on infiltrating CD4+ Treg and Teffector cells in glioblastoma, we sought to better understand the role of PD-1 on these infiltrating CD4+ Treg and Teffector cells. To this end, we performed functional and transcriptional profiling using CD4+ Treg and Teffector cells isolated from healthy donors and glioblastoma patients (from both tumors and blood).
Lien
Mots-clés
Versions (1)
- 23/06/2023 23/06/2023 - Chiara Middel
Détendeur de droits
David Hafler, Yale School of Medicine, New Haven, CT, USA
Téléchargé le
23 juin 2023
DOI
Pour une demande vous connecter.
Licence
Creative Commons BY 4.0
Modèle Commentaires :
Ici, vous pouvez faire des commentaires sur le modèle. À partir des bulles de texte, vous pouvez laisser des commentaires spécifiques sur les groupes Item et les Item.
Groupe Item commentaires pour :
Item commentaires pour :
Vous devez être connecté pour pouvoir télécharger des formulaires. Veuillez vous connecter ou s’inscrire gratuitement.
dbGaP phs001079 PD-1+ and PD-1- CD4+ Teff and Treg cells in Glioblastoma and Health
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
- Subject ID, sample ID, and sample use of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
- Sample ID, MGMT methylation, sorted as PD1pos or PD1- or total, sample obtained from tumor or blood, and tumor stage of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
- Subject ID, sample ID, and sample use of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
- Sample ID, MGMT methylation, sorted as PD1pos or PD1- or total, sample obtained from tumor or blood, and tumor stage of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
C0680251 (UMLS CUI [1,2])
C0229664 (UMLS CUI [1,2])
C0370003 (UMLS CUI [1,3])
C1516698 (UMLS CUI [1,4])
C0006118 (UMLS CUI [1,5])
C0543467 (UMLS CUI [1,6])
C1292533 (UMLS CUI [2,1])
C0229664 (UMLS CUI [2,2])
C0370003 (UMLS CUI [2,3])
C1516698 (UMLS CUI [2,4])
C1708335 (UMLS CUI [2,5])