ID
45794
Description
Principal Investigator: David Hafler, Yale School of Medicine, New Haven, CT, USA MeSH: Glioblastoma,Programmed Cell Death 1 Receptor https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001079 PD-1 is an important immune checkpoint inhibitor that shows great promise in the clinic, particularly for melanoma and lung cancers. Since PD-1 is also expressed on infiltrating CD4+ Treg and Teffector cells in glioblastoma, we sought to better understand the role of PD-1 on these infiltrating CD4+ Treg and Teffector cells. To this end, we performed functional and transcriptional profiling using CD4+ Treg and Teffector cells isolated from healthy donors and glioblastoma patients (from both tumors and blood).
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Keywords
Versions (1)
- 6/23/23 6/23/23 - Chiara Middel
Copyright Holder
David Hafler, Yale School of Medicine, New Haven, CT, USA
Uploaded on
June 23, 2023
DOI
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License
Creative Commons BY 4.0
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dbGaP phs001079 PD-1+ and PD-1- CD4+ Teff and Treg cells in Glioblastoma and Health
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
- Subject ID, sample ID, and sample use of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
- Sample ID, MGMT methylation, sorted as PD1pos or PD1- or total, sample obtained from tumor or blood, and tumor stage of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
- Subject ID, sample ID, and sample use of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
- Sample ID, MGMT methylation, sorted as PD1pos or PD1- or total, sample obtained from tumor or blood, and tumor stage of participants with or without glioblastoma and involved in the "Transcriptional Profiling of PD-1+ and PD-1- Teff and Treg Cells in Glioblastoma and Health" project.
C0680251 (UMLS CUI [1,2])
C0229664 (UMLS CUI [1,2])
C0370003 (UMLS CUI [1,3])
C1516698 (UMLS CUI [1,4])
C0006118 (UMLS CUI [1,5])
C0543467 (UMLS CUI [1,6])
C1292533 (UMLS CUI [2,1])
C0229664 (UMLS CUI [2,2])
C0370003 (UMLS CUI [2,3])
C1516698 (UMLS CUI [2,4])
C1708335 (UMLS CUI [2,5])