ID
4577
Beschrijving
The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed. Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain. Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system. The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.
Trefwoorden
Versies (1)
- 11-12-13 11-12-13 - Martin Dugas
Geüploaded op
11 december 2013
DOI
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Licentie
Creative Commons BY-NC 3.0 Legacy
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Eligibility NCT00148161 # Stuttering
Eligibility
- StudyEvent: Eligibility
Beschrijving
Ausschlusskriterien
Beschrijving
Neurological diseases
Datatype
boolean
Alias
- UMLS CUI
- C0027765
- ICD10CM
- G00-G99
- ICD9CM
- 349.9
- MDR
- 10029202
- SNOMED CT 2010_0731
- 118940003
Beschrijving
Psychiatric diseases
Datatype
boolean
Alias
- UMLS CUI
- C0004936
- ICD10CM
- F01-F99
- ICD9CM
- 290-319.99
- MDR
- 10061284
- SNOMED CT 2010_0731
- 74732009
Beschrijving
Medication with neurological effective drugs
Datatype
boolean
Alias
- UMLS CUI
- C0007680
- SNOMED CT 2010_0731
- 372752008
Beschrijving
Implants with magnetic impact
Datatype
boolean
Alias
- UMLS CUI
- C0021102
- SNOMED CT 2010_0731
- #####
Beschrijving
Medizinische Konzepte
Beschrijving
Age
Datatype
string
Alias
- UMLS CUI
- C0001779
- SNOMED CT 2010_0731
- 424144002
- LNC
- MTHU010047
Beschrijving
Gender
Datatype
string
Alias
- UMLS CUI
- C0079399
- SNOMED CT 2010_0731
- 263495000
- LNC
- MTHU002975
Beschrijving
Healthy Subject
Datatype
string
Alias
- UMLS CUI
- C1708335
Beschrijving
stuttering
Datatype
string
Alias
- UMLS CUI
- C0038506
- MDR
- 10042267
- SNOMED CT 2010_0731
- 39423001
Beschrijving
Primary stuttering
Datatype
string
Alias
- UMLS CUI
- C0454537
- SNOMED CT 2010_0731
- 229626005
Beschrijving
Right handed
Datatype
string
Alias
- UMLS CUI
- C0344333
- SNOMED CT 2010_0731
- 46669005
Beschrijving
Hearing normal
Datatype
string
Alias
- UMLS CUI
- C0234725
- SNOMED CT 2010_0731
- 162339002
Beschrijving
nervous system disorder
Datatype
string
Alias
- UMLS CUI
- C0027765
- ICD10CM
- G00-G99
- ICD9CM
- 349.9
- MDR
- 10029202
- SNOMED CT 2010_0731
- 118940003
Beschrijving
Mental disorders
Datatype
string
Alias
- UMLS CUI
- C0004936
- ICD10CM
- F01-F99
- ICD9CM
- 290-319.99
- MDR
- 10061284
- SNOMED CT 2010_0731
- 74732009
Beschrijving
Central Nervous System Agents
Datatype
string
Alias
- UMLS CUI
- C0007680
- SNOMED CT 2010_0731
- 372752008
Beschrijving
Implant
Datatype
string
Alias
- UMLS CUI
- C0021102
- SNOMED CT 2010_0731
- #####
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Eligibility
- StudyEvent: Eligibility
424144002 (SNOMED CT 2010_0731)
MTHU010047 (LNC)
263495000 (SNOMED CT 2010_0731)
MTHU002975 (LNC)
10042267 (MDR)
39423001 (SNOMED CT 2010_0731)
C0454537 (UMLS CUI)
229626005 (SNOMED CT 2010_0731)
46669005 (SNOMED CT 2010_0731)
162339002 (SNOMED CT 2010_0731)
G00-G99 (ICD10CM)
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10029202 (MDR)
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74732009 (SNOMED CT 2010_0731)
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263495000 (SNOMED CT 2010_0731)
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39423001 (SNOMED CT 2010_0731)
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G00-G99 (ICD10CM)
349.9 (ICD9CM)
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