ID

45779

Descrizione

Principal Investigator: Stacey Gabriel, PhD, Broad Institute, Boston, MA, USA MeSH: Myocardial Infarction https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001101 The Malmo Diet and Cancer Study (MDCS) is a community-based prospective epidemiologic cohort of 28,449 subjects who were recruited for baseline examination between 1991 and 1996. From this cohort, 6103 subjects were randomly selected to participate in a cardiovascular cohort (MDCSCC), which seeks to investigate risk factors for cardiovascular disease. This study is a subset of those samples. All exome sequencing was performed at the Broad Institute of Harvard and MIT; samples sequence capture was performed using Illumina's ICE Capture reagent and sequencing was performed on an Illumina HiSeq 2000 or 2500.

collegamento

dbGaP-study=phs001101

Keywords

versioni (1)
  1. 20/06/23 20/06/23 - Chiara Middel
Titolare del copyright

Stacey Gabriel, PhD, Broad Institute, Boston, MA, USA

Caricato su

20 giugno 2023

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
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dbGaP phs001101 MIGen_ExS: MDC

Inglese

Eligibility Criteria

5 moduli  
Inclusion and exclusion criteria
Descrizione

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
We performed a nested case-control experiment for incident cardiovascular events. Cardiovascular events are defined as myocardial infarction, coronary revascularization, or stroke. We included participants who passed the following sample quality control measures: contamination < 5%, missingness < 5%, concordance with genome-wide array data when available, and Ti/Tv, total variants / depth, and F inbreeding coefficient outliers. We also excluded individuals who were genotypically found to be within three degrees of relatedness.
Descrizione

Elig.phs001101.v1.p1.1

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0027775
UMLS CUI [1,2]
C1551358
UMLS CUI [1,3]
C1320716
UMLS CUI [2,1]
C1704788
UMLS CUI [2,2]
C1320716
UMLS CUI [2,3]
C0027051
UMLS CUI [2,4]
C0038454
UMLS CUI [2,5]
C0877341
UMLS CUI [3,1]
C1512693
UMLS CUI [3,2]
C2347026
UMLS CUI [3,3]
C0034378
UMLS CUI [3,4]
C2349974
UMLS CUI [3,5]
C4553529
UMLS CUI [3,6]
C0017428
UMLS CUI [3,7]
C1510941
UMLS CUI [3,8]
C1511726
UMLS CUI [3,9]
C0456603
UMLS CUI [3,10]
C0439810
UMLS CUI [3,11]
C0205419
UMLS CUI [3,12]
C0205125
UMLS CUI [3,13]
C0681921
UMLS CUI [3,14]
C3846158
UMLS CUI [4,1]
C0680251
UMLS CUI [4,2]
C0017431
UMLS CUI [4,3]
C0205396
UMLS CUI [4,4]
C3639750
Cases include those who developed cardiovascular events after a median follow-up of 17.1 years. We excluded individuals who had clinical cardiovascular disease at baseline examination. Controls were matched to each case in the matched nested case-control experiment. Controls were matched for age (+/- 2 years), sex, smoking status, type 2 diabetes status.
Descrizione

Elig.phs001101.v1.p1.2

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1698493
UMLS CUI [1,2]
C1320716
UMLS CUI [1,3]
C2939193
UMLS CUI [1,4]
C0449238
UMLS CUI [1,5]
C1522577
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0007222
UMLS CUI [2,3]
C1442488
UMLS CUI [2,4]
C0031809
UMLS CUI [3,1]
C0009932
UMLS CUI [3,2]
C1708943
UMLS CUI [3,3]
C0027775
UMLS CUI [3,4]
C0001779
UMLS CUI [3,5]
C0079399
UMLS CUI [3,6]
C1519386
UMLS CUI [3,7]
C0011860
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Similar models

Eligibility Criteria

5 moduli
Name
genere
Description | Question | Decode (Coded Value)
Tipo di dati
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001101.v1.p1.1
Item
We performed a nested case-control experiment for incident cardiovascular events. Cardiovascular events are defined as myocardial infarction, coronary revascularization, or stroke. We included participants who passed the following sample quality control measures: contamination < 5%, missingness < 5%, concordance with genome-wide array data when available, and Ti/Tv, total variants / depth, and F inbreeding coefficient outliers. We also excluded individuals who were genotypically found to be within three degrees of relatedness.
boolean
C0027775 (UMLS CUI [1,1])
C1551358 (UMLS CUI [1,2])
C1320716 (UMLS CUI [1,3])
C1704788 (UMLS CUI [2,1])
C1320716 (UMLS CUI [2,2])
C0027051 (UMLS CUI [2,3])
C0038454 (UMLS CUI [2,4])
C0877341 (UMLS CUI [2,5])
C1512693 (UMLS CUI [3,1])
C2347026 (UMLS CUI [3,2])
C0034378 (UMLS CUI [3,3])
C2349974 (UMLS CUI [3,4])
C4553529 (UMLS CUI [3,5])
C0017428 (UMLS CUI [3,6])
C1510941 (UMLS CUI [3,7])
C1511726 (UMLS CUI [3,8])
C0456603 (UMLS CUI [3,9])
C0439810 (UMLS CUI [3,10])
C0205419 (UMLS CUI [3,11])
C0205125 (UMLS CUI [3,12])
C0681921 (UMLS CUI [3,13])
C3846158 (UMLS CUI [3,14])
C0680251 (UMLS CUI [4,1])
C0017431 (UMLS CUI [4,2])
C0205396 (UMLS CUI [4,3])
C3639750 (UMLS CUI [4,4])
Elig.phs001101.v1.p1.2
Item
Cases include those who developed cardiovascular events after a median follow-up of 17.1 years. We excluded individuals who had clinical cardiovascular disease at baseline examination. Controls were matched to each case in the matched nested case-control experiment. Controls were matched for age (+/- 2 years), sex, smoking status, type 2 diabetes status.
boolean
C1698493 (UMLS CUI [1,1])
C1320716 (UMLS CUI [1,2])
C2939193 (UMLS CUI [1,3])
C0449238 (UMLS CUI [1,4])
C1522577 (UMLS CUI [1,5])
C0680251 (UMLS CUI [2,1])
C0007222 (UMLS CUI [2,2])
C1442488 (UMLS CUI [2,3])
C0031809 (UMLS CUI [2,4])
C0009932 (UMLS CUI [3,1])
C1708943 (UMLS CUI [3,2])
C0027775 (UMLS CUI [3,3])
C0001779 (UMLS CUI [3,4])
C0079399 (UMLS CUI [3,5])
C1519386 (UMLS CUI [3,6])
C0011860 (UMLS CUI [3,7])
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