ID
45771
Descrição
Principal Investigator: Carl D. Novina, PhD, Dana-Farber Cancer Institute, Boston, MA, USA MeSH: Melanoma, Cutaneous Malignant https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001115 The purpose of this study was to obtain tissue specimens derived from patients with melanoma to generate research tools to advance our understanding of the genetics, pathogenesis, and therapeutics of melanoma. Briefly, tissue was obtained from metastatic lesions and used to generate clonal primary cell lines from melanoma cells and fibroblasts from the tumor microenvironment. RNA was extracted from low passage cell lines using Trizol reagent. cDNA libraries were prepared using the TruSeq mRNA sample preparation kit, v2 (Illumina) and sequenced on the HiSeq 2000 platform (Illumina). The submitted files are bam files that contain both unaligned and aligned reads (human genome, build hg19).
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Versões (1)
- 19/06/2023 19/06/2023 - Chiara Middel
Titular dos direitos
Carl D. Novina, PhD, Dana-Farber Cancer Institute, Boston, MA, USA
Transferido a
19 de junho de 2023
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs001115 Tissue Specimens from Patients with Melanoma for Genetic Analysis
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, subject aliases, and case control status of the subject. All subjects are melanoma patients.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample aliases and sample use.
- This subject phenotype table contains subject IDs, sex and age of subject.
- This sample attributes table contains sample IDs, body site where sample was collected, analyte type, tumor status, histological type, tumor stage, and known driver mutations in NRAS or BRAF gene.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, subject aliases, and case control status of the subject. All subjects are melanoma patients.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample aliases and sample use.
- This subject phenotype table contains subject IDs, sex and age of subject.
- This sample attributes table contains sample IDs, body site where sample was collected, analyte type, tumor status, histological type, tumor stage, and known driver mutations in NRAS or BRAF gene.
C0680251 (UMLS CUI [1,2])
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C0347984 (UMLS CUI [5,4])
C2936643 (UMLS CUI [5,5])
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C0347984 (UMLS CUI [6,4])
C2347804 (UMLS CUI [6,5])