ID
45770
Descrição
Principal Investigator: William C. Hahn, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, USA MeSH: Sarcoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001121 Due to the paucity of patient derived models in rare cancers, identification of therapeutic targets remains challenging. We developed a patient derived model, CLF-PED-015-T, from a patient with an undifferentiated sarcoma. From this model, we performed pooled RNAi and CRISPR-Cas9 negative selection screens and integrated that with a small molecule screen. Integration of these data identified CDK4 and XPO1 as potential therapeutic targets.
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- 2023-06-19 2023-06-19 - Chiara Middel
Titular dos direitos
William C. Hahn, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, USA
Transferido a
19 juni 2023
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs001121 Integrated Genetic and Pharmacologic Interrogation of Rare Cancers
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs and consent information.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, gender, age, and primary disease state of patient.
- This sample attributes table contains sample ID, sample type, tumor type, original material type, and analyte type.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs and consent information.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, gender, age, and primary disease state of patient.
- This sample attributes table contains sample ID, sample type, tumor type, original material type, and analyte type.
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