ID
45770
Beskrivning
Principal Investigator: William C. Hahn, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, USA MeSH: Sarcoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001121 Due to the paucity of patient derived models in rare cancers, identification of therapeutic targets remains challenging. We developed a patient derived model, CLF-PED-015-T, from a patient with an undifferentiated sarcoma. From this model, we performed pooled RNAi and CRISPR-Cas9 negative selection screens and integrated that with a small molecule screen. Integration of these data identified CDK4 and XPO1 as potential therapeutic targets.
Länk
Nyckelord
Versioner (1)
- 2023-06-19 2023-06-19 - Chiara Middel
Rättsinnehavare
William C. Hahn, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, USA
Uppladdad den
19 juni 2023
DOI
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Licens
Creative Commons BY 4.0
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dbGaP phs001121 Integrated Genetic and Pharmacologic Interrogation of Rare Cancers
This sample attributes table contains sample ID, sample type, tumor type, original material type, and analyte type.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs and consent information.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, gender, age, and primary disease state of patient.
- This sample attributes table contains sample ID, sample type, tumor type, original material type, and analyte type.
Similar models
This sample attributes table contains sample ID, sample type, tumor type, original material type, and analyte type.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs and consent information.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, gender, age, and primary disease state of patient.
- This sample attributes table contains sample ID, sample type, tumor type, original material type, and analyte type.
C1299222 (UMLS CUI [1,2])
C0475752 (UMLS CUI [1,2])
C0205307 (UMLS CUI [1,3])
C0449438 (UMLS CUI [1,4])
C2347026 (UMLS CUI [1,5])
C4263544 (UMLS CUI [1,2])
C2347026 (UMLS CUI [1,3])
C0520510 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,3])
C0028606 (UMLS CUI [1,4])
C0185115 (UMLS CUI [1,5])