0 Bedömningar
ID

45765

Beskrivning

Principal Investigator: Thomas A. Sellers, PhD, MPH, Moffitt Cancer Center, Tampa, FL, USA MeSH: Ovarian Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001133 *(Excerpted/paraphrased from original grant application)*: FOCI seeks to expand our understanding of epithelial ovarian cancer through a coordinated and comprehensive approach. Project 1 will focus on discovery, expansion, and replication. By pooling GWAS, we expect to identify new associations and achieve independent replication, explore whether there are risk variants specific for histologic subtypes, and evaluate structural polymorphisms - copy number variants - as risk factors. Finally, Project 1 will leverage the GWAS data to correlate DNA variants with a new endpoint - survival. Project 2 will focus on biological studies designed to help inform interpretation of findings from Project 1. This will include efforts to identify the functional consequences of variants and improve understanding of biological mechanisms. Project 3 will include epidemiologic studies of gene by gene interaction, gene by environment interaction, and development of risk prediction models. The collective effort builds upon the strengths and history of collaboration inherent in the Ovarian Cancer Association Consortium (OCAC), a multidisciplinary group comprised of epidemiologists, genetic epidemiologists, statistical geneticists, molecular and cell biologists and clinicians that was formed in 2005. *The FOCI Cohort is utilized in the following dbGaP sub-studies.* To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page phs001133 FOCI Cohort.- phs001131 Affymetrix Exome Chip - phs001132 GWAS Meta Analysis - phs001142 Mayo Omni Express - phs001150 Mayo 2 5M

Länk

dbGaP-study=phs001133

Nyckelord

Versioner (1)
  1. 2023-06-16 2023-06-16 - Chiara Middel
Rättsinnehavare

Thomas A. Sellers, PhD, MPH, Moffitt Cancer Center, Tampa, FL, USA

Uppladdad den

16 juni 2023

DOI

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Licens

Creative Commons BY 4.0
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    dbGaP phs001133 Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)

    Engelsk

    Subject ID, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.

    10 Formulär  
    1. StudyEvent: SEV1
      1. Subject ID, consent group, and affection status of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      2. Subject ID, sample ID, sample use variable, and study of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      3. Subject ID, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      4. Sample ID, analyte type, and body site where sample was obtained of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      5. Subject ID, gender, ancestry, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      6. Sample ID, analyte type, body site where sample was obtained, tumor status of sample, and indicator if DNA was whole genome amplified of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      7. Subject ID, subject ancestry, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, primary site of tumor, and indicator if analyzed in European GWAS by FOCI of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      8. Sample ID, analyte type, body site where sample was obtained, indicator for worse duplicates for sample, and indicator for failed QC criterion of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      9. Subject ID, tumor behavior, tumor grade, tumor histology, primary cancer site or control status, and age at diagnosis (cases) or interview (controls) of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      10. Sample ID, analyte type, body site where sample was obtained, and tumor status of sample of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    pht007497
    Beskrivning

    pht007497

    Alias
    UMLS CUI [1,1]
    C3846158 (Other Coding)
    LOINC
    LA4728-7
    De-identified subject ID
    Beskrivning

    SUBJECT_ID

    Datatyp

    string

    Alias
    UMLS CUI [1,1]
    C4684638 (De-identified Information)
    UMLS CUI [1,2]
    C2348585 (Clinical Trial Subject Unique Identifier)
    Primary cancer site or control status
    Beskrivning

    PRIMARY_SITE

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C0449695 (Site of primary lesion)
    SNOMED
    246312001
    LOINC
    MTHU010322
    UMLS CUI [2,1]
    C0243148 (control aspects)
    UMLS CUI [2,2]
    C0449438 (Status)
    SNOMED
    263490005
    LOINC
    LP73412-6
    Tumor behavior
    Beskrivning

    BEHAVIOR

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C0006826 (Malignant Neoplasms)
    SNOMED
    363346000
    LOINC
    LP100805-3
    UMLS CUI [1,2]
    C0004927 (Behavior)
    SNOMED
    844005
    LOINC
    LP89757-6
    Tumor grade
    Beskrivning

    GRADE

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C0919553 (Histopathologic Grade)
    SNOMED
    371469007
    LOINC
    LP94898-1
    Tumor histology
    Beskrivning

    HISTOLOGY

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C0027651 (Neoplasms)
    SNOMED
    108369006
    UMLS CUI [1,2]
    C0019638 (Histology)
    Age at diagnosis (cases) or interview (controls)
    Beskrivning

    REF_AGE

    Datatyp

    text

    Måttenheter
    • Years
    Alias
    UMLS CUI [1,1]
    C1706256 (Clinical Study Case)
    UMLS CUI [1,2]
    C1828181 (Age at diagnosis)
    SNOMED
    423493009
    LOINC
    LP114958-4
    UMLS CUI [2,1]
    C0009932 (Control Groups)
    UMLS CUI [2,2]
    C0001779 (Age)
    SNOMED
    424144002
    LOINC
    LP28815-6
    UMLS CUI [2,3]
    C0011008 (Date in time)
    SNOMED
    410671006
    UMLS CUI [2,4]
    C0021822 (Interview)
    LOINC
    LA4601-6
    Tillbaka till toppen

    Similar models

    Subject ID, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.

    10 Formulär
    1. StudyEvent: SEV1
      1. Subject ID, consent group, and affection status of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      2. Subject ID, sample ID, sample use variable, and study of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      3. Subject ID, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      4. Sample ID, analyte type, and body site where sample was obtained of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      5. Subject ID, gender, ancestry, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      6. Sample ID, analyte type, body site where sample was obtained, tumor status of sample, and indicator if DNA was whole genome amplified of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      7. Subject ID, subject ancestry, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, primary site of tumor, and indicator if analyzed in European GWAS by FOCI of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      8. Sample ID, analyte type, body site where sample was obtained, indicator for worse duplicates for sample, and indicator for failed QC criterion of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      9. Subject ID, tumor behavior, tumor grade, tumor histology, primary cancer site or control status, and age at diagnosis (cases) or interview (controls) of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
      10. Sample ID, analyte type, body site where sample was obtained, and tumor status of sample of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    Name
    Typ
    Description | Question | Decode (Coded Value)
    Datatyp
    Alias
    Item Group
    pht007497
    C3846158 (UMLS CUI [1,1])
    SUBJECT_ID
    Item
    De-identified subject ID
    string
    C4684638 (UMLS CUI [1,1])
    C2348585 (UMLS CUI [1,2])
    PRIMARY_SITE
    Item
    Primary cancer site or control status
    text
    C0449695 (UMLS CUI [1,1])
    C0243148 (UMLS CUI [2,1])
    C0449438 (UMLS CUI [2,2])
    BEHAVIOR
    Item
    Tumor behavior
    text
    C0006826 (UMLS CUI [1,1])
    C0004927 (UMLS CUI [1,2])
    Item
    Tumor grade
    text
    C0919553 (UMLS CUI [1,1])
    GRADE
    Code List
    Tumor grade
    CL Item
    Well differentiated (1)
    CL Item
    Moderately differentiated (2)
    CL Item
    Poorly differentiated (3)
    CL Item
    Undifferentiated (4)
    CL Item
    High grade (3/4-whether it is 3 or 4 is pending) (5)
    CL Item
    Low grade (1/2-whether it is 1 or 2 is pending) (6)
    CL Item
    NA (7)
    CL Item
    DK (8)
    HISTOLOGY
    Item
    Tumor histology
    text
    C0027651 (UMLS CUI [1,1])
    C0019638 (UMLS CUI [1,2])
    Item
    Age at diagnosis (cases) or interview (controls)
    text
    C1706256 (UMLS CUI [1,1])
    C1828181 (UMLS CUI [1,2])
    C0009932 (UMLS CUI [2,1])
    C0001779 (UMLS CUI [2,2])
    C0011008 (UMLS CUI [2,3])
    C0021822 (UMLS CUI [2,4])
    REF_AGE
    Code List
    Age at diagnosis (cases) or interview (controls)
    CL Item
    DK (888)
    Tillbaka till toppen 

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