ID

45765

Description

Principal Investigator: Thomas A. Sellers, PhD, MPH, Moffitt Cancer Center, Tampa, FL, USA MeSH: Ovarian Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001133 *(Excerpted/paraphrased from original grant application)*: FOCI seeks to expand our understanding of epithelial ovarian cancer through a coordinated and comprehensive approach. Project 1 will focus on discovery, expansion, and replication. By pooling GWAS, we expect to identify new associations and achieve independent replication, explore whether there are risk variants specific for histologic subtypes, and evaluate structural polymorphisms - copy number variants - as risk factors. Finally, Project 1 will leverage the GWAS data to correlate DNA variants with a new endpoint - survival. Project 2 will focus on biological studies designed to help inform interpretation of findings from Project 1. This will include efforts to identify the functional consequences of variants and improve understanding of biological mechanisms. Project 3 will include epidemiologic studies of gene by gene interaction, gene by environment interaction, and development of risk prediction models. The collective effort builds upon the strengths and history of collaboration inherent in the Ovarian Cancer Association Consortium (OCAC), a multidisciplinary group comprised of epidemiologists, genetic epidemiologists, statistical geneticists, molecular and cell biologists and clinicians that was formed in 2005. *The FOCI Cohort is utilized in the following dbGaP sub-studies.* To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page phs001133 FOCI Cohort.- phs001131 Affymetrix Exome Chip - phs001132 GWAS Meta Analysis - phs001142 Mayo Omni Express - phs001150 Mayo 2 5M

Link

dbGaP-study=phs001133

Keywords

Versions (1)
  1. 6/16/23 6/16/23 - Chiara Middel
Copyright Holder

Thomas A. Sellers, PhD, MPH, Moffitt Cancer Center, Tampa, FL, USA

Uploaded on

June 16, 2023

DOI

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License

Creative Commons BY 4.0
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dbGaP phs001133 Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)

English

Subject ID, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.

10 forms  
  1. StudyEvent: SEV1
    1. Subject ID, consent group, and affection status of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    2. Subject ID, sample ID, sample use variable, and study of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    3. Subject ID, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    4. Sample ID, analyte type, and body site where sample was obtained of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    5. Subject ID, gender, ancestry, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    6. Sample ID, analyte type, body site where sample was obtained, tumor status of sample, and indicator if DNA was whole genome amplified of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    7. Subject ID, subject ancestry, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, primary site of tumor, and indicator if analyzed in European GWAS by FOCI of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    8. Sample ID, analyte type, body site where sample was obtained, indicator for worse duplicates for sample, and indicator for failed QC criterion of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    9. Subject ID, tumor behavior, tumor grade, tumor histology, primary cancer site or control status, and age at diagnosis (cases) or interview (controls) of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    10. Sample ID, analyte type, body site where sample was obtained, and tumor status of sample of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
pht007497
Description

pht007497

Alias
UMLS CUI [1,1]
C3846158
De-identified subject ID
Description

SUBJECT_ID

Data type

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
Primary cancer site or control status
Description

PRIMARY_SITE

Data type

text

Alias
UMLS CUI [1,1]
C0449695
UMLS CUI [2,1]
C0243148
UMLS CUI [2,2]
C0449438
Tumor behavior
Description

BEHAVIOR

Data type

text

Alias
UMLS CUI [1,1]
C0006826
UMLS CUI [1,2]
C0004927
Tumor grade
Description

GRADE

Data type

text

Alias
UMLS CUI [1,1]
C0919553
Tumor histology
Description

HISTOLOGY

Data type

text

Alias
UMLS CUI [1,1]
C0027651
UMLS CUI [1,2]
C0019638
Age at diagnosis (cases) or interview (controls)
Description

REF_AGE

Data type

text

Measurement units
  • Years
Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1828181
UMLS CUI [2,1]
C0009932
UMLS CUI [2,2]
C0001779
UMLS CUI [2,3]
C0011008
UMLS CUI [2,4]
C0021822
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Similar models

Subject ID, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.

10 forms
  1. StudyEvent: SEV1
    1. Subject ID, consent group, and affection status of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    2. Subject ID, sample ID, sample use variable, and study of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    3. Subject ID, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    4. Sample ID, analyte type, and body site where sample was obtained of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    5. Subject ID, gender, ancestry, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, and primary site of tumor of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    6. Sample ID, analyte type, body site where sample was obtained, tumor status of sample, and indicator if DNA was whole genome amplified of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    7. Subject ID, subject ancestry, age at diagnosis, tumor description including tumor behavior, tumor grade, tumor histology, tumor status of sample, primary site of tumor, and indicator if analyzed in European GWAS by FOCI of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    8. Sample ID, analyte type, body site where sample was obtained, indicator for worse duplicates for sample, and indicator for failed QC criterion of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    9. Subject ID, tumor behavior, tumor grade, tumor histology, primary cancer site or control status, and age at diagnosis (cases) or interview (controls) of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
    10. Sample ID, analyte type, body site where sample was obtained, and tumor status of sample of participants with or without ovarian cancer and involved in the "Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)" project.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
pht007497
C3846158 (UMLS CUI [1,1])
SUBJECT_ID
Item
De-identified subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
PRIMARY_SITE
Item
Primary cancer site or control status
text
C0449695 (UMLS CUI [1,1])
C0243148 (UMLS CUI [2,1])
C0449438 (UMLS CUI [2,2])
BEHAVIOR
Item
Tumor behavior
text
C0006826 (UMLS CUI [1,1])
C0004927 (UMLS CUI [1,2])
Item
Tumor grade
text
C0919553 (UMLS CUI [1,1])
GRADE
Code List
Tumor grade
CL Item
Well differentiated (1)
CL Item
Moderately differentiated (2)
CL Item
Poorly differentiated (3)
CL Item
Undifferentiated (4)
CL Item
High grade (3/4-whether it is 3 or 4 is pending) (5)
CL Item
Low grade (1/2-whether it is 1 or 2 is pending) (6)
CL Item
NA (7)
CL Item
DK (8)
HISTOLOGY
Item
Tumor histology
text
C0027651 (UMLS CUI [1,1])
C0019638 (UMLS CUI [1,2])
Item
Age at diagnosis (cases) or interview (controls)
text
C1706256 (UMLS CUI [1,1])
C1828181 (UMLS CUI [1,2])
C0009932 (UMLS CUI [2,1])
C0001779 (UMLS CUI [2,2])
C0011008 (UMLS CUI [2,3])
C0021822 (UMLS CUI [2,4])
REF_AGE
Code List
Age at diagnosis (cases) or interview (controls)
CL Item
DK (888)
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