ID

45764

Description

Principal Investigator: Chanock SJ, MD, National Cancer Institute, Bethesda, MD, USA MeSH: Thyroid Cancer, Papillary,Chernobyl Nuclear Accident,Neoplasms, Radiation-Induced,Iodine Radioisotopes https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001134 The April 26, 1986 accident at the Chernobyl nuclear power plant in northern Ukraine resulted in the release of radioactive contaminants, which were deposited in the surrounding areas in Ukraine, Belarus, and Russia. The main radiation-related health effect resulting from these exposures is the increased occurrence of thyroid cancer among individuals who were children at the time of the accident or born shortly thereafter. The purpose of this study was to conduct a comprehensive genomic landscape analysis of papillary thyroid tumors arising in individuals who were exposed as children to radioactive iodine (I-131) from the Chernobyl nuclear power plant accident.

Link

dbGaP-study=phs001134

Keywords

Versions (1)
  1. 6/16/23 6/16/23 - Chiara Middel
Copyright Holder

Chanock SJ, MD, National Cancer Institute, Bethesda, MD, USA

Uploaded on

June 16, 2023

DOI

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License

Creative Commons BY 4.0
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dbGaP phs001134 Radiation-related Genomic Profile of Papillary Thyroid Cancer after the Chernobyl Accident

English

Eligibility Criteria

6 forms  
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
In utero or < 19 years of age on April 26, 1986 (cases) or born > 9 months after the accident (comparison population of unexposed individuals)
Description

Elig.phs001134.v1.p1.1

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0001779
UMLS CUI [1,3]
C0011008
UMLS CUI [1,4]
C1449773
UMLS CUI [2,1]
C1707455
UMLS CUI [2,2]
C0441833
UMLS CUI [2,3]
C2349018
UMLS CUI [2,4]
C0421451
UMLS CUI [2,5]
C0205455
UMLS CUI [2,6]
C0439231
UMLS CUI [2,7]
C0231290
UMLS CUI [2,8]
C1449773
Residence in one of the most contaminated territories (oblasts or states) of Ukraine, specifically, Zhytomyr, Kiev (Kyiv in Ukrainian), or Chernigov (Chernihiv in Ukrainian)
Description

Elig.phs001134.v1.p1.2

Data type

boolean

Alias
UMLS CUI [1,1]
C2316883
UMLS CUI [1,2]
C0205279
UMLS CUI [1,3]
C2983136
UMLS CUI [1,4]
C0681784
Histopathologically confirmed diagnosis of a first primary papillary thyroid cancer based on review of tumor tissue by an international panel of experts and medical record data documenting no prior cancer history
Description

Elig.phs001134.v1.p1.3

Data type

boolean

Alias
UMLS CUI [1,1]
C0679557
UMLS CUI [1,2]
C0205225
UMLS CUI [1,3]
C0238463
UMLS CUI [1,4]
C0699752
UMLS CUI [1,5]
C0475358
UMLS CUI [1,6]
C2985541
UMLS CUI [1,7]
C0025102
UMLS CUI [1,8]
C1511726
UMLS CUI [1,9]
C1298908
UMLS CUI [1,10]
C0262926
UMLS CUI [1,11]
C0006826
Availability of I-131 dose estimates for cases
Description

Elig.phs001134.v1.p1.4

Data type

boolean

Alias
UMLS CUI [1,1]
C1698493
UMLS CUI [1,2]
C0470187
UMLS CUI [1,3]
C0750572
UMLS CUI [1,4]
C0303029
UMLS CUI [1,5]
C0178602
Availability of fresh frozen thyroid tissue with sufficient, high quality nucleic acids
Description

Elig.phs001134.v1.p1.5

Data type

boolean

Alias
UMLS CUI [1,1]
C0470187
UMLS CUI [1,2]
C4697670
UMLS CUI [1,3]
C0040132
UMLS CUI [1,4]
C0456204
UMLS CUI [1,5]
C0205410
UMLS CUI [1,6]
C0205250
UMLS CUI [1,7]
C0332306
UMLS CUI [1,8]
C0028606
Availability of non-tumor thyroid tissue and/or a blood sample (collected years later)
Description

Elig.phs001134.v1.p1.6

Data type

boolean

Alias
UMLS CUI [1,1]
C0470187
UMLS CUI [1,2]
C0040132
UMLS CUI [1,3]
C1292533
UMLS CUI [1,4]
C0178913
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Similar models

Eligibility Criteria

6 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001134.v1.p1.1
Item
In utero or < 19 years of age on April 26, 1986 (cases) or born > 9 months after the accident (comparison population of unexposed individuals)
boolean
C1706256 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C0011008 (UMLS CUI [1,3])
C1449773 (UMLS CUI [1,4])
C1707455 (UMLS CUI [2,1])
C0441833 (UMLS CUI [2,2])
C2349018 (UMLS CUI [2,3])
C0421451 (UMLS CUI [2,4])
C0205455 (UMLS CUI [2,5])
C0439231 (UMLS CUI [2,6])
C0231290 (UMLS CUI [2,7])
C1449773 (UMLS CUI [2,8])
Elig.phs001134.v1.p1.2
Item
Residence in one of the most contaminated territories (oblasts or states) of Ukraine, specifically, Zhytomyr, Kiev (Kyiv in Ukrainian), or Chernigov (Chernihiv in Ukrainian)
boolean
C2316883 (UMLS CUI [1,1])
C0205279 (UMLS CUI [1,2])
C2983136 (UMLS CUI [1,3])
C0681784 (UMLS CUI [1,4])
Elig.phs001134.v1.p1.3
Item
Histopathologically confirmed diagnosis of a first primary papillary thyroid cancer based on review of tumor tissue by an international panel of experts and medical record data documenting no prior cancer history
boolean
C0679557 (UMLS CUI [1,1])
C0205225 (UMLS CUI [1,2])
C0238463 (UMLS CUI [1,3])
C0699752 (UMLS CUI [1,4])
C0475358 (UMLS CUI [1,5])
C2985541 (UMLS CUI [1,6])
C0025102 (UMLS CUI [1,7])
C1511726 (UMLS CUI [1,8])
C1298908 (UMLS CUI [1,9])
C0262926 (UMLS CUI [1,10])
C0006826 (UMLS CUI [1,11])
Elig.phs001134.v1.p1.4
Item
Availability of I-131 dose estimates for cases
boolean
C1698493 (UMLS CUI [1,1])
C0470187 (UMLS CUI [1,2])
C0750572 (UMLS CUI [1,3])
C0303029 (UMLS CUI [1,4])
C0178602 (UMLS CUI [1,5])
Elig.phs001134.v1.p1.5
Item
Availability of fresh frozen thyroid tissue with sufficient, high quality nucleic acids
boolean
C0470187 (UMLS CUI [1,1])
C4697670 (UMLS CUI [1,2])
C0040132 (UMLS CUI [1,3])
C0456204 (UMLS CUI [1,4])
C0205410 (UMLS CUI [1,5])
C0205250 (UMLS CUI [1,6])
C0332306 (UMLS CUI [1,7])
C0028606 (UMLS CUI [1,8])
Elig.phs001134.v1.p1.6
Item
Availability of non-tumor thyroid tissue and/or a blood sample (collected years later)
boolean
C0470187 (UMLS CUI [1,1])
C0040132 (UMLS CUI [1,2])
C1292533 (UMLS CUI [1,3])
C0178913 (UMLS CUI [1,4])
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