ID
45763
Descrição
Principal Investigator: Wade H. Berrettini, MD, PhD, University of Pennsylvania MeSH: Opioid-Related Disorders,Substance-Related Disorders https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001135 The Starting Treatment with Agonist Replacement Therapy (START) study was a 24-week, open-label, randomized trial of methadone *versus* Suboxone (buprenorphine/naloxone) for the treatment of opioid dependence. Patients were over the age of 18 and met DSM-IV qualifications for opioid dependence. The primary goal of the study was to determine if either medicine was associated with liver toxicity issues in this vulnerable patient population. Liver enzymes were measured at four time points. Urinalysis for opioids, cocaine, cannabis, benzodiazepines, and methamphetamine were performed on a weekly basis. A flexible dosing scheme was used during which physicians could alter medication dose based on withdrawal symptoms and urinalysis results. Neither medication was found to be associated with liver enzyme levels. In version 2 of this study, a text file containing 7704 SNPs with large allele frequency discrepancy as compared to 1000 Genomes is included. Users have the option to exlude these 7704 SNPs.
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Versões (1)
- 16/06/2023 16/06/2023 - Chiara Middel
Titular dos direitos
Wade H. Berrettini, MD, PhD, University of Pennsylvania
Transferido a
16 de junho de 2023
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs001135 Starting Treatment with Agonist Replacement Therapies (START)
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table informs of subject ID, subject consent group, source repository in which subject originated, ID assigned to the subject by the source repository, and subject's case - control status for opioid dependence.
- This pedigree data table provides subject's family information including the mother and father of the subject. This pedigree table also informs of subject's sex.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This table also informs of the source repository in which the sample was obtained and the ID assigned to the sample by the source repository.
- This subject phenotypes data table provides information about the abuse and dependency status of the subject for: opioids, cocaine, alcohol, nicotine, cannabis, stimulants, sedatives, and 'other' drugs. It also informs of subject's age, sex, race, live/death status, and the diagnostic system used on the subject.
- This sample attributes data table informs of body site where sample was collected and sample analyte type.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table informs of subject ID, subject consent group, source repository in which subject originated, ID assigned to the subject by the source repository, and subject's case - control status for opioid dependence.
- This pedigree data table provides subject's family information including the mother and father of the subject. This pedigree table also informs of subject's sex.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This table also informs of the source repository in which the sample was obtained and the ID assigned to the sample by the source repository.
- This subject phenotypes data table provides information about the abuse and dependency status of the subject for: opioids, cocaine, alcohol, nicotine, cannabis, stimulants, sedatives, and 'other' drugs. It also informs of subject's age, sex, race, live/death status, and the diagnostic system used on the subject.
- This sample attributes data table informs of body site where sample was collected and sample analyte type.
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