ID
45754
Description
Principal Investigator: Carole Ober, PhD, University of Chicago, Chicago, IL, USA MeSH: Asthma,Serum IgE https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001156 The EVE Asthma Genetics Consortium comprises U.S. investigators who have conducted genome-wide association studies (GWAS) of asthma; the main objective is to combine results of individual studies to increase the overall power to identify loci for asthma and asthma-associated traits. The consortium includes investigators at 9 U.S. institutions with GWAS results for 10,000 individuals representing European American, African American, African Caribbean, U.S. Hispanic, and Mexican populations and includes the following studies:- The Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE) - The Genetic Research on Asthma in the African Diaspora (GRAAD) Study - The Genetics of Asthma in Latino Americans (GALA 1) Study - The Childhood Asthma Management Program (CAMP) - The Childhood Asthma Research and Education (CARE) Network - The Children's Health Study (CHS) - Mexico City Childhood Asthma Study (MCCAS) - The Chicago Asthma Genetics Study (CAG)* liThe National Heart, Lung, and Blood Institute Collaborative Studies of the Genetics of Asthma (CSGA)*/li liThe Severe Asthma Research Program (SARP)*/li (*CAG, CSGA, and SARP are part of the NHLBI-supported SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) consortium.) For the GWAS, we developed a common set of 1 million genotyped and imputed SNPs from the EVE Asthma Genetics Consortium to be tested for association with asthma and associated phenotypes in all samples and combined p-values for a grand meta-analysis for asthma gene discovery. A subset of 296 individuals representing African American, European American, and Latino ancestry were selected for whole genome sequencing. The broad goals of this project were to characterize the genetic architecture of asthma and associated quantitative phenotypes (e.g., lung function, total serum IgE) in ethnically diverse populations from the U.S., Mexico, Puerto Rico, and Barbados.
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- 6/5/23 6/5/23 - Chiara Middel
Copyright Holder
Carole Ober, PhD, University of Chicago, Chicago, IL, USA
Uploaded on
June 5, 2023
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Creative Commons BY 4.0
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dbGaP phs001156 The EVE Asthma Genetics Consortium: Building Upon GWAS
This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table includes subjects IDs and consent group information.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype data table includes subject's gender, race (n=2 variables), asthma status, age of asthma onset and diagnosis, allergy symptoms, skin test results for any aeroallergen, and food allergy diagnosis.
- This sample attributes data table includes analyte type and tumor status.
Similar models
This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table includes subjects IDs and consent group information.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype data table includes subject's gender, race (n=2 variables), asthma status, age of asthma onset and diagnosis, allergy symptoms, skin test results for any aeroallergen, and food allergy diagnosis.
- This sample attributes data table includes analyte type and tumor status.