ID
45748
Descrizione
Principal Investigator: Maria Teresa Landi, MD, PhD, National Institutes of Health, Bethesda, MD, USA MeSH: Adenocarcinoma of lung https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001169 We performed a comprehensive analysis of intratumor heterogeneity of somatic mutations in cancer driver genes, copy number aberrations and DNA methylation in 292 tumor samples from 84 lung adenocarcinoma (LUAD) patients from the Environment And Genetics in Lung cancer Etiology (EAGLE) study. SNVs of 37 established lung cancer driver genes were profiled by deep target sequencing in 180 tumor samples and 55 blood samples and 1 buccal sample from 56 subjects. Somatic copy number alterations were profiled using SNP arrays in 268 tumor samples from 80 subjects. DNA methylation levels were profiled with methylation arrays in 205 tumor samples and 74 normal tissue samples from 68 subjects.
collegamento
Keywords
versioni (1)
- 04/06/23 04/06/23 - Chiara Middel
Titolare del copyright
Maria Teresa Landi, MD, PhD, National Institutes of Health, Bethesda, MD, USA
Caricato su
4 giugno 2023
DOI
Per favore, per richiedere un accesso.
Licenza
Creative Commons BY 4.0
Commenti del modello :
Puoi commentare il modello dati qui. Tramite i fumetti nei gruppi di articoli e articoli è possibile aggiungere commenti a quelli in modo specifico.
Commenti del gruppo di articoli per :
Commenti dell'articolo per :
Per scaricare i modelli di dati devi essere registrato. Per favore accesso o registrati GRATIS.
dbGaP phs001169 Integrative Analysis of Lung Adenocarcinoma (Version 2)
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with lung adenocarcinoma and involved in the "Integrative Analysis of Lung Adenocarcinoma in EAGLE" project.
- Subject ID, sample ID, and sample use variable obtained from participants with lung adenocarcinoma and involved in the "Integrative Analysis of Lung Adenocarcinoma in EAGLE" project.
- Subject ID, gender, age categories, and affection status of participants with lung adenocarcinoma and involved in the "Integrative Analysis of Lung Adenocarcinoma in EAGLE" project.
- Sample ID, analyte type, body site, histological type, and tumor status of samples obtained from participants with lung adenocarcinoma and involved in the "Integrative Analysis of Lung Adenocarcinoma in EAGLE" project.
Similar models
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants with lung adenocarcinoma and involved in the "Integrative Analysis of Lung Adenocarcinoma in EAGLE" project.
- Subject ID, sample ID, and sample use variable obtained from participants with lung adenocarcinoma and involved in the "Integrative Analysis of Lung Adenocarcinoma in EAGLE" project.
- Subject ID, gender, age categories, and affection status of participants with lung adenocarcinoma and involved in the "Integrative Analysis of Lung Adenocarcinoma in EAGLE" project.
- Sample ID, analyte type, body site, histological type, and tumor status of samples obtained from participants with lung adenocarcinoma and involved in the "Integrative Analysis of Lung Adenocarcinoma in EAGLE" project.
C0680251 (UMLS CUI [1,2])