Informations:
Erreur:
ID
45722
Description
Principal Investigator: Edward E. Walsh, M.D, University of Rochester Medical Center, Rochester, NY, USA MeSH: Respiratory Syncytial Virus Infections,Infant https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001201 A prospective multi-year clinical translational study including three cohorts of term infants experiencing their first Respiratory Syncytial Virus (RSV) season. All infants are less than or equal to nine months of age at study entry. The three subject cohorts represent the full spectrum of RSV disease severity and include a birth cohort, a cohort of infants hospitalized for RSV disease and infants evaluated at ambulatory settings for RSV infection. All infants are followed longitudinally and evaluated at recognition of acute RSV infection and twice during convalescence. Innate and adaptive immune status are comprehensively measured in association with clinical, environmental, viral, and bacteriologic factors. Genome-wide expression is assessed in the nasal airways, and in sorted peripheral blood lymphocytes. The study goal is to Identify host responses to RSV infection and factors associated with severe disease.
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Mots-clés
Versions (1)
- 24/05/2023 24/05/2023 - Chiara Middel
Détendeur de droits
Edward E. Walsh, M.D, University of Rochester Medical Center, Rochester, NY, USA
Téléchargé le
24 mai 2023
DOI
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Licence
Creative Commons BY 4.0
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dbGaP phs001201 ASsessing and Predicting Infant RSV Effects and Severity (AsPIRES) Study
This subject phenotype table contains subject ID, delivery method, gestational age, birth weight, breastfeeding, family size, smoke exposure, enrollment season, sex, race, ethnicity, age at enrollment, and derived score for breastfeeding.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject ID and consent information.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotype table contains subject ID, 12 genes (B2M, CD83, CES1, DNAI2, DNAH5, FOXRED1, GPI, KRT8, OAS1, PPIA, SOCS6, TYROBP) being expressed, and scores tied to gene expression.
- This subject phenotype table contains subject ID, delivery method, gestational age, birth weight, breastfeeding, family size, smoke exposure, enrollment season, sex, race, ethnicity, age at enrollment, and derived score for breastfeeding.
- This subject phenotype table contains subject ID, and any detected bacteria or virus pathogens including H.influenzae, M.catarrhalis, S.pneumoniae, coronavirus, and rhinovirus.
- This sample attribute table contains sample ID, and bacteria taxon including Moraxellaceae, Streptococcaceae, and Pasteurellaceae.
- This sample attribute table contains sample ID, body site, analyte type, tumor status, histological type, publication, attribute, sequence number, sample days, presence of bacteria and virus (adenovirus, bocavirus, coronavirus, C. pneumoniae, enterobacteriaceae, Flu A or B, H. influenzae, metapneumovirus, catarrhalis, M. hominis, M. pneumoniae, parechovirus, PIV, rhinovirus, respiratory syncytial virus, S. pneumoniae, and ureaplasma), antibody titer scores of serum (Fa, Ga, Gb, RSV A, RSV B, nasal swab, and nasal wash), and read count.
- This subject phenotype table contains subject ID, age at time of visit, presence of symptoms (wheezing, rales, retraction, cyanosis, apnea, lethargy, and poor air movement), maximum respiratory rate, worst saturated oxygen score, length of stay, strain of RSV (Respiratory Syncytial Virus), derived RSV severity score, RSV severity label, and antibiotic use.
Similar models
This subject phenotype table contains subject ID, delivery method, gestational age, birth weight, breastfeeding, family size, smoke exposure, enrollment season, sex, race, ethnicity, age at enrollment, and derived score for breastfeeding.
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject ID and consent information.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotype table contains subject ID, 12 genes (B2M, CD83, CES1, DNAI2, DNAH5, FOXRED1, GPI, KRT8, OAS1, PPIA, SOCS6, TYROBP) being expressed, and scores tied to gene expression.
- This subject phenotype table contains subject ID, delivery method, gestational age, birth weight, breastfeeding, family size, smoke exposure, enrollment season, sex, race, ethnicity, age at enrollment, and derived score for breastfeeding.
- This subject phenotype table contains subject ID, and any detected bacteria or virus pathogens including H.influenzae, M.catarrhalis, S.pneumoniae, coronavirus, and rhinovirus.
- This sample attribute table contains sample ID, and bacteria taxon including Moraxellaceae, Streptococcaceae, and Pasteurellaceae.
- This sample attribute table contains sample ID, body site, analyte type, tumor status, histological type, publication, attribute, sequence number, sample days, presence of bacteria and virus (adenovirus, bocavirus, coronavirus, C. pneumoniae, enterobacteriaceae, Flu A or B, H. influenzae, metapneumovirus, catarrhalis, M. hominis, M. pneumoniae, parechovirus, PIV, rhinovirus, respiratory syncytial virus, S. pneumoniae, and ureaplasma), antibody titer scores of serum (Fa, Ga, Gb, RSV A, RSV B, nasal swab, and nasal wash), and read count.
- This subject phenotype table contains subject ID, age at time of visit, presence of symptoms (wheezing, rales, retraction, cyanosis, apnea, lethargy, and poor air movement), maximum respiratory rate, worst saturated oxygen score, length of stay, strain of RSV (Respiratory Syncytial Virus), derived RSV severity score, RSV severity label, and antibiotic use.
Name
Type
Description | Question | Decode (Coded Value)
Type de données
Alias
SUBJECT_ID
Item
De-identified Subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
C2348585 (UMLS CUI [1,2])
EnrollmentSeason
Item
Year of study of enrollment
string
C0439234 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
C0011008 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
CL Item
Male (1)
C0086582 (UMLS CUI [1,1])
CL Item
Not Reported (3)
CL Item
Female (2)
C0086287 (UMLS CUI [1,1])
CL Item
Asian (Asian)
CL Item
Black (Black)
CL Item
Multi-Racial (Multi-Racial)
CL Item
Native American (Native American)
CL Item
White (White)
CL Item
Not Hispanic or Latino (1)
CL Item
Hispanic or Latino (0)
CL Item
Not Reported (2)
CL Item
Vaginal (1)
CL Item
C-section (2)
gestational_age
Item
Subject's gestational age
float
C0017504 (UMLS CUI [1,1])
age_enrollment
Item
Subject's age at time of enrollment
float
C0001779 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
C0011008 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
birth_weight
Item
Subject's weight at birth
float
C0005612 (UMLS CUI [1,1])
CL Item
Yes (1)
CL Item
No (0)
breastfeed_summary_score
Item
Derived score for breastfeeding. Summed and divided by the number of months that the subject had data.
float
C0006147 (UMLS CUI [1,1])
C1441547 (UMLS CUI [1,2])
C0449820 (UMLS CUI [1,3])
C1441506 (UMLS CUI [2,1])
C0237753 (UMLS CUI [2,2])
C0439231 (UMLS CUI [2,3])
C0470187 (UMLS CUI [2,4])
C1511726 (UMLS CUI [2,5])
C1691222 (UMLS CUI [2,6])
C1441547 (UMLS CUI [1,2])
C0449820 (UMLS CUI [1,3])
C1441506 (UMLS CUI [2,1])
C0237753 (UMLS CUI [2,2])
C0439231 (UMLS CUI [2,3])
C0470187 (UMLS CUI [2,4])
C1511726 (UMLS CUI [2,5])
C1691222 (UMLS CUI [2,6])
family_size
Item
Number of adults and other children in home
text
C0008059 (UMLS CUI [1,1])
C0001675 (UMLS CUI [1,2])
C0557510 (UMLS CUI [1,3])
C0001675 (UMLS CUI [1,2])
C0557510 (UMLS CUI [1,3])
CL Item
Yes (1)
CL Item
No (0)