ID

45722

Descrição

Principal Investigator: Edward E. Walsh, M.D, University of Rochester Medical Center, Rochester, NY, USA MeSH: Respiratory Syncytial Virus Infections,Infant https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001201 A prospective multi-year clinical translational study including three cohorts of term infants experiencing their first Respiratory Syncytial Virus (RSV) season. All infants are less than or equal to nine months of age at study entry. The three subject cohorts represent the full spectrum of RSV disease severity and include a birth cohort, a cohort of infants hospitalized for RSV disease and infants evaluated at ambulatory settings for RSV infection. All infants are followed longitudinally and evaluated at recognition of acute RSV infection and twice during convalescence. Innate and adaptive immune status are comprehensively measured in association with clinical, environmental, viral, and bacteriologic factors. Genome-wide expression is assessed in the nasal airways, and in sorted peripheral blood lymphocytes. The study goal is to Identify host responses to RSV infection and factors associated with severe disease.

Link

dbGaP-study=phs001201

Palavras-chave

Versões (1)
  1. 24/05/2023 24/05/2023 - Chiara Middel
Titular dos direitos

Edward E. Walsh, M.D, University of Rochester Medical Center, Rochester, NY, USA

Transferido a

24 de maio de 2023

DOI

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Licença

Creative Commons BY 4.0
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dbGaP phs001201 ASsessing and Predicting Infant RSV Effects and Severity (AsPIRES) Study

Inglês

This subject phenotype table contains subject ID, delivery method, gestational age, birth weight, breastfeeding, family size, smoke exposure, enrollment season, sex, race, ethnicity, age at enrollment, and derived score for breastfeeding.

9 Formulários  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The subject consent file includes subject ID and consent information.
    3. This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
    4. This subject phenotype table contains subject ID, 12 genes (B2M, CD83, CES1, DNAI2, DNAH5, FOXRED1, GPI, KRT8, OAS1, PPIA, SOCS6, TYROBP) being expressed, and scores tied to gene expression.
    5. This subject phenotype table contains subject ID, delivery method, gestational age, birth weight, breastfeeding, family size, smoke exposure, enrollment season, sex, race, ethnicity, age at enrollment, and derived score for breastfeeding.
    6. This subject phenotype table contains subject ID, and any detected bacteria or virus pathogens including H.influenzae, M.catarrhalis, S.pneumoniae, coronavirus, and rhinovirus.
    7. This sample attribute table contains sample ID, and bacteria taxon including Moraxellaceae, Streptococcaceae, and Pasteurellaceae.
    8. This sample attribute table contains sample ID, body site, analyte type, tumor status, histological type, publication, attribute, sequence number, sample days, presence of bacteria and virus (adenovirus, bocavirus, coronavirus, C. pneumoniae, enterobacteriaceae, Flu A or B, H. influenzae, metapneumovirus, catarrhalis, M. hominis, M. pneumoniae, parechovirus, PIV, rhinovirus, respiratory syncytial virus, S. pneumoniae, and ureaplasma), antibody titer scores of serum (Fa, Ga, Gb, RSV A, RSV B, nasal swab, and nasal wash), and read count.
    9. This subject phenotype table contains subject ID, age at time of visit, presence of symptoms (wheezing, rales, retraction, cyanosis, apnea, lethargy, and poor air movement), maximum respiratory rate, worst saturated oxygen score, length of stay, strain of RSV (Respiratory Syncytial Virus), derived RSV severity score, RSV severity label, and antibiotic use.
pht007557
Descrição

pht007557

Alias
UMLS CUI [1,1]
C3846158
De-identified Subject ID
Descrição

SUBJECT_ID

Tipo de dados

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
Year of study of enrollment
Descrição

EnrollmentSeason

Tipo de dados

string

Alias
UMLS CUI [1,1]
C0439234
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C1516879
Gender of participant
Descrição

sex

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0079399
Race of participant
Descrição

race

Tipo de dados

string

Alias
UMLS CUI [1,1]
C0034510
Subject ethnicity
Descrição

Ethnicity

Tipo de dados

string

Alias
UMLS CUI [1,1]
C0015031
Delivery method
Descrição

delivery_method

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0565867
Subject's gestational age
Descrição

gestational_age

Tipo de dados

float

Unidades de medida
  • Weeks
Alias
UMLS CUI [1,1]
C0017504
Weeks
Subject's age at time of enrollment
Descrição

age_enrollment

Tipo de dados

float

Unidades de medida
  • Months
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C1516879
Months
Subject's weight at birth
Descrição

birth_weight

Tipo de dados

float

Unidades de medida
  • kg
Alias
UMLS CUI [1,1]
C0005612
kg
Any breastfeeding
Descrição

breastfed

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0006147
Derived score for breastfeeding. Summed and divided by the number of months that the subject had data.
Descrição

breastfeed_summary_score

Tipo de dados

float

Alias
UMLS CUI [1,1]
C0006147
UMLS CUI [1,2]
C1441547
UMLS CUI [1,3]
C0449820
UMLS CUI [2,1]
C1441506
UMLS CUI [2,2]
C0237753
UMLS CUI [2,3]
C0439231
UMLS CUI [2,4]
C0470187
UMLS CUI [2,5]
C1511726
UMLS CUI [2,6]
C1691222
Number of adults and other children in home
Descrição

family_size

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0008059
UMLS CUI [1,2]
C0001675
UMLS CUI [1,3]
C0557510
Tabacco smoke exposure
Descrição

smoke_exposure

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0439994
UMLS CUI [1,2]
C1948106
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Similar models

This subject phenotype table contains subject ID, delivery method, gestational age, birth weight, breastfeeding, family size, smoke exposure, enrollment season, sex, race, ethnicity, age at enrollment, and derived score for breastfeeding.

9 Formulários
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The subject consent file includes subject ID and consent information.
    3. This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
    4. This subject phenotype table contains subject ID, 12 genes (B2M, CD83, CES1, DNAI2, DNAH5, FOXRED1, GPI, KRT8, OAS1, PPIA, SOCS6, TYROBP) being expressed, and scores tied to gene expression.
    5. This subject phenotype table contains subject ID, delivery method, gestational age, birth weight, breastfeeding, family size, smoke exposure, enrollment season, sex, race, ethnicity, age at enrollment, and derived score for breastfeeding.
    6. This subject phenotype table contains subject ID, and any detected bacteria or virus pathogens including H.influenzae, M.catarrhalis, S.pneumoniae, coronavirus, and rhinovirus.
    7. This sample attribute table contains sample ID, and bacteria taxon including Moraxellaceae, Streptococcaceae, and Pasteurellaceae.
    8. This sample attribute table contains sample ID, body site, analyte type, tumor status, histological type, publication, attribute, sequence number, sample days, presence of bacteria and virus (adenovirus, bocavirus, coronavirus, C. pneumoniae, enterobacteriaceae, Flu A or B, H. influenzae, metapneumovirus, catarrhalis, M. hominis, M. pneumoniae, parechovirus, PIV, rhinovirus, respiratory syncytial virus, S. pneumoniae, and ureaplasma), antibody titer scores of serum (Fa, Ga, Gb, RSV A, RSV B, nasal swab, and nasal wash), and read count.
    9. This subject phenotype table contains subject ID, age at time of visit, presence of symptoms (wheezing, rales, retraction, cyanosis, apnea, lethargy, and poor air movement), maximum respiratory rate, worst saturated oxygen score, length of stay, strain of RSV (Respiratory Syncytial Virus), derived RSV severity score, RSV severity label, and antibiotic use.
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
pht007557
C3846158 (UMLS CUI [1,1])
SUBJECT_ID
Item
De-identified Subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
EnrollmentSeason
Item
Year of study of enrollment
string
C0439234 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
Item
Gender of participant
text
C0079399 (UMLS CUI [1,1])
sex
Code List
Gender of participant
CL Item
Male (1)
C0086582 (UMLS CUI [1,1])
CL Item
Not Reported (3)
CL Item
Female (2)
C0086287 (UMLS CUI [1,1])
Item
Race of participant
string
C0034510 (UMLS CUI [1,1])
race
Code List
Race of participant
CL Item
Asian (Asian)
CL Item
Black (Black)
CL Item
Multi-Racial (Multi-Racial)
CL Item
Native American (Native American)
CL Item
White (White)
Item
Subject ethnicity
string
C0015031 (UMLS CUI [1,1])
Ethnicity
Code List
Subject ethnicity
CL Item
Not Hispanic or Latino (1)
CL Item
Hispanic or Latino (0)
CL Item
Not Reported (2)
Item
Delivery method
text
C0565867 (UMLS CUI [1,1])
delivery_method
Code List
Delivery method
CL Item
Vaginal (1)
CL Item
C-section (2)
gestational_age
Item
Subject's gestational age
float
C0017504 (UMLS CUI [1,1])
age_enrollment
Item
Subject's age at time of enrollment
float
C0001779 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C1516879 (UMLS CUI [1,3])
birth_weight
Item
Subject's weight at birth
float
C0005612 (UMLS CUI [1,1])
Item
Any breastfeeding
text
C0006147 (UMLS CUI [1,1])
breastfed
Code List
Any breastfeeding
CL Item
Yes (1)
CL Item
No (0)
breastfeed_summary_score
Item
Derived score for breastfeeding. Summed and divided by the number of months that the subject had data.
float
C0006147 (UMLS CUI [1,1])
C1441547 (UMLS CUI [1,2])
C0449820 (UMLS CUI [1,3])
C1441506 (UMLS CUI [2,1])
C0237753 (UMLS CUI [2,2])
C0439231 (UMLS CUI [2,3])
C0470187 (UMLS CUI [2,4])
C1511726 (UMLS CUI [2,5])
C1691222 (UMLS CUI [2,6])
family_size
Item
Number of adults and other children in home
text
C0008059 (UMLS CUI [1,1])
C0001675 (UMLS CUI [1,2])
C0557510 (UMLS CUI [1,3])
Item
Tabacco smoke exposure
text
C0439994 (UMLS CUI [1,1])
C1948106 (UMLS CUI [1,2])
smoke_exposure
Code List
Tabacco smoke exposure
CL Item
Yes (1)
CL Item
No (0)
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