ID

45719

Descrição

Principal Investigator: Bernice Porjesz, Ph.D, SUNY Downstate Medical Center, Brooklyn, NY, USA MeSH: Alcoholism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001208 This is a family study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US. COGA has gathered detailed, standardized data on study participants, including diagnostic and neurophysiological assessments. This sample has already proved successful in identifying several genes that influence the risk for alcoholism and neurophysiological endophenotypes, which have been independently replicated. COGA data were included as part of two Genetic Analysis Workshops, and the phenotypes are familiar to the genetics community. Alcoholic probands were recruited from treatment facilities, assessed by personal interview, and after securing permission, other family members were also assessed. A set of comparison families was drawn from the same communities as the families recruited through an alcoholic proband. Assessment involved a detailed personal interview developed for this project, the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), which gathers detailed information on alcoholism related symptoms along with other drugs and psychiatric symptoms. Many participants also came to the laboratories for electroencephalographic studies. Neurophysiological features that have been shown to be useful endophenotypes for which we have linkage and in some cases association results are included on a subset of the case-control sample: the beta power of the resting electroencephalogram (EEG), the P3(00) amplitude of the visual event-related potential (ERP), and the theta and delta event-related oscillations (EROs) underlying the P3.

Link

dbGaP-study=phs001208

Palavras-chave

Versões (1)
  1. 22/05/2023 22/05/2023 - Chiara Middel
Titular dos direitos

Bernice Porjesz, Ph.D, SUNY Downstate Medical Center, Brooklyn, NY, USA

Transferido a

22 de maio de 2023

DOI

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Licença

Creative Commons BY 4.0
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dbGaP phs001208 COGA: Smokescreen GWAS

Inglês

Eligibility Criteria

6 Formulários  
Inclusion and exclusion criteria
Descrição

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
Descrição

Elig.phs001208.v2.p1.1

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0242800
UMLS CUI [1,2]
C0521116
UMLS CUI [1,3]
C0021562
UMLS CUI [1,4]
C0029921
UMLS CUI [1,5]
C1709762
UMLS CUI [1,6]
C0085762
UMLS CUI [1,7]
C0205394
UMLS CUI [1,8]
C0038580
UMLS CUI [2,1]
C0150543
UMLS CUI [2,2]
C0205197
UMLS CUI [2,3]
C0332152
UMLS CUI [2,4]
C1516879
A potential proband: must not have used intravenous drugs more than 30 times lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas: Indiana, New York, St. Louis, Connecticut, Iowa, San Diego.
Descrição

Elig.phs001208.v2.p1.2

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C3245505
UMLS CUI [1,2]
C1948021
UMLS CUI [2,1]
C1524063
UMLS CUI [2,2]
C0086181
UMLS CUI [2,3]
C0439092
UMLS CUI [2,4]
C3816446
UMLS CUI [2,5]
C0439546
UMLS CUI [2,6]
C4071830
UMLS CUI [2,7]
C1298908
UMLS CUI [2,8]
C1524063
UMLS CUI [2,9]
C0086181
UMLS CUI [2,10]
C3828652
UMLS CUI [2,11]
C0332152
UMLS CUI [2,12]
C0220908
UMLS CUI [3,1]
C1298908
UMLS CUI [3,2]
C0205394
UMLS CUI [3,3]
C3846017
UMLS CUI [4,1]
C1298908
UMLS CUI [4,2]
C0019693
UMLS CUI [5,1]
C1517194
UMLS CUI [5,2]
C0564215
UMLS CUI [5,3]
C0376245
UMLS CUI [5,4]
C2982691
UMLS CUI [5,5]
C1524084
UMLS CUI [5,6]
C0017446
Each COGA site recruited Control families consisting of two living parents and three or more full siblings, aged 14 or older. The Control Probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were to be representative of the general population and do not have to be unaffected individuals. Therefore, a Control family would not be eliminated if alcoholism is present among any of its members.
Descrição

Elig.phs001208.v2.p1.3

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0242800
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0015576
UMLS CUI [1,4]
C0205448
UMLS CUI [1,5]
C2584946
UMLS CUI [1,6]
C0030551
UMLS CUI [1,7]
C0205449
UMLS CUI [1,8]
C0037047
UMLS CUI [2,1]
C0439605
UMLS CUI [2,2]
C1707491
UMLS CUI [2,3]
C0870078
UMLS CUI [2,4]
C0018720
UMLS CUI [2,5]
C0011344
UMLS CUI [3,1]
C1882932
UMLS CUI [3,2]
C0683971
UMLS CUI [4,1]
C1298908
UMLS CUI [4,2]
C0680251
UMLS CUI [4,3]
C0009932
UMLS CUI [4,4]
C0086282
UMLS CUI [4,5]
C0001973
We extend families through all affecteds, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affecteds. If any of these relatives were affected, we extend to his/her first-degree relatives, and continue if any of them are affected. In addition, extension by leapfrogging over a living or dead unaffected into a branch containing at least two first-degree relatives of the "leapfrogee" who have 3 implications by history.
Descrição

Elig.phs001208.v2.p1.4

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C2348563
UMLS CUI [1,2]
C0231448
UMLS CUI [1,3]
C0015576
UMLS CUI [1,4]
C0522476
UMLS CUI [1,5]
C1517194
UMLS CUI [2,1]
C1517194
UMLS CUI [2,2]
C0522476
UMLS CUI [2,3]
C0231448
UMLS CUI [2,4]
C1517194
UMLS CUI [3,1]
C1524062
UMLS CUI [3,2]
C3846158
UMLS CUI [3,3]
C0522477
UMLS CUI [3,4]
C1253959
UMLS CUI [3,5]
C1148543
UMLS CUI [3,6]
C0205448
UMLS CUI [3,7]
C1517194
UMLS CUI [3,8]
C0086282
UMLS CUI [3,9]
C0262926
UMLS CUI [3,10]
C0012634
UMLS CUI [3,11]
C3146298
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Similar models

Eligibility Criteria

6 Formulários
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001208.v2.p1.1
Item
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
boolean
C0242800 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])
C0021562 (UMLS CUI [1,3])
C0029921 (UMLS CUI [1,4])
C1709762 (UMLS CUI [1,5])
C0085762 (UMLS CUI [1,6])
C0205394 (UMLS CUI [1,7])
C0038580 (UMLS CUI [1,8])
C0150543 (UMLS CUI [2,1])
C0205197 (UMLS CUI [2,2])
C0332152 (UMLS CUI [2,3])
C1516879 (UMLS CUI [2,4])
Elig.phs001208.v2.p1.2
Item
A potential proband: must not have used intravenous drugs more than 30 times lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas: Indiana, New York, St. Louis, Connecticut, Iowa, San Diego.
boolean
C3245505 (UMLS CUI [1,1])
C1948021 (UMLS CUI [1,2])
C1524063 (UMLS CUI [2,1])
C0086181 (UMLS CUI [2,2])
C0439092 (UMLS CUI [2,3])
C3816446 (UMLS CUI [2,4])
C0439546 (UMLS CUI [2,5])
C4071830 (UMLS CUI [2,6])
C1298908 (UMLS CUI [2,7])
C1524063 (UMLS CUI [2,8])
C0086181 (UMLS CUI [2,9])
C3828652 (UMLS CUI [2,10])
C0332152 (UMLS CUI [2,11])
C0220908 (UMLS CUI [2,12])
C1298908 (UMLS CUI [3,1])
C0205394 (UMLS CUI [3,2])
C3846017 (UMLS CUI [3,3])
C1298908 (UMLS CUI [4,1])
C0019693 (UMLS CUI [4,2])
C1517194 (UMLS CUI [5,1])
C0564215 (UMLS CUI [5,2])
C0376245 (UMLS CUI [5,3])
C2982691 (UMLS CUI [5,4])
C1524084 (UMLS CUI [5,5])
C0017446 (UMLS CUI [5,6])
Elig.phs001208.v2.p1.3
Item
Each COGA site recruited Control families consisting of two living parents and three or more full siblings, aged 14 or older. The Control Probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were to be representative of the general population and do not have to be unaffected individuals. Therefore, a Control family would not be eliminated if alcoholism is present among any of its members.
boolean
C0242800 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0015576 (UMLS CUI [1,3])
C0205448 (UMLS CUI [1,4])
C2584946 (UMLS CUI [1,5])
C0030551 (UMLS CUI [1,6])
C0205449 (UMLS CUI [1,7])
C0037047 (UMLS CUI [1,8])
C0439605 (UMLS CUI [2,1])
C1707491 (UMLS CUI [2,2])
C0870078 (UMLS CUI [2,3])
C0018720 (UMLS CUI [2,4])
C0011344 (UMLS CUI [2,5])
C1882932 (UMLS CUI [3,1])
C0683971 (UMLS CUI [3,2])
C1298908 (UMLS CUI [4,1])
C0680251 (UMLS CUI [4,2])
C0009932 (UMLS CUI [4,3])
C0086282 (UMLS CUI [4,4])
C0001973 (UMLS CUI [4,5])
Elig.phs001208.v2.p1.4
Item
We extend families through all affecteds, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affecteds. If any of these relatives were affected, we extend to his/her first-degree relatives, and continue if any of them are affected. In addition, extension by leapfrogging over a living or dead unaffected into a branch containing at least two first-degree relatives of the "leapfrogee" who have 3 implications by history.
boolean
C2348563 (UMLS CUI [1,1])
C0231448 (UMLS CUI [1,2])
C0015576 (UMLS CUI [1,3])
C0522476 (UMLS CUI [1,4])
C1517194 (UMLS CUI [1,5])
C1517194 (UMLS CUI [2,1])
C0522476 (UMLS CUI [2,2])
C0231448 (UMLS CUI [2,3])
C1517194 (UMLS CUI [2,4])
C1524062 (UMLS CUI [3,1])
C3846158 (UMLS CUI [3,2])
C0522477 (UMLS CUI [3,3])
C1253959 (UMLS CUI [3,4])
C1148543 (UMLS CUI [3,5])
C0205448 (UMLS CUI [3,6])
C1517194 (UMLS CUI [3,7])
C0086282 (UMLS CUI [3,8])
C0262926 (UMLS CUI [3,9])
C0012634 (UMLS CUI [3,10])
C3146298 (UMLS CUI [3,11])
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