Información:
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ID
45706
Descripción
Principal Investigator: Jiang He, PhD, Tulane University, New Orleans, LA, USA MeSH: Arterial Pressure, Mean,Blood Pressure https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001217 The GenSalt study aims to identify genes which interact with dietary sodium and potassium intake to influence blood pressure in Han Chinese participants from rural north China. Whole genome sequencing will be conducted among 1,860 participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) Study. We will work in collaboration with participating TOPMed studies to identify novel common, low-frequency and rare variants associated with an array of cardiometabolic phenotypes. In addition, we will explore the relation of low-frequency and rare variants with salt-sensitivity among GenSalt study participants.
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Versiones (1)
- 16/5/23 16/5/23 - Simon Heim
Titular de derechos de autor
Jiang He, PhD, Tulane University, New Orleans, LA, USA
Subido en
16 de mayo de 2023
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs001217 NHLBI TOPMed: Genetic Epidemiology Network of Salt Sensitivity (GenSalt)
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent group information.
- This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, sex of subjects, and monozygotic twin IDs.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotype data table includes gender, age, birthplace, race, systolic and diastolic blood pressure, and mean arterial pressure.
- This sample attributes table includes body site where sample was collected, analyte type, tumor status, histological type, sequencing center, funding source, TOPMed phase, project, and study name.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent data table contains subject IDs and consent group information.
- This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, sex of subjects, and monozygotic twin IDs.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
- This subject phenotype data table includes gender, age, birthplace, race, systolic and diastolic blood pressure, and mean arterial pressure.
- This sample attributes table includes body site where sample was collected, analyte type, tumor status, histological type, sequencing center, funding source, TOPMed phase, project, and study name.
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
*Inclusion criteria for proband* Men or women aged 18-60 years
Item
*Inclusion criteria for proband* Men or women aged 18-60 years
boolean
C0001779 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C1948021 (UMLS CUI [1,3])
C1512693 (UMLS CUI [1,2])
C1948021 (UMLS CUI [1,3])
Systolic BP 130-160mm Hg and/or diastolic BP 85-100mm Hg
Item
Systolic BP 130-160mm Hg and/or diastolic BP 85-100mm Hg
boolean
C0871470 (UMLS CUI [1,1])
C0428883 (UMLS CUI [1,2])
C0428883 (UMLS CUI [1,2])
Both parents (two-generation nuclear family) or at least one parent (three or more generation family) are available and willing to participate in the study
Item
Both parents (two-generation nuclear family) or at least one parent (three or more generation family) are available and willing to participate in the study
boolean
C0470187 (UMLS CUI [1,1])
C0028574 (UMLS CUI [1,2])
C0030551 (UMLS CUI [1,3])
C0600109 (UMLS CUI [1,4])
C0028574 (UMLS CUI [1,2])
C0030551 (UMLS CUI [1,3])
C0600109 (UMLS CUI [1,4])
At least one sibling meets eligibility criteria for participation
Item
At least one sibling meets eligibility criteria for participation
boolean
C1516637 (UMLS CUI [1,1])
C0679823 (UMLS CUI [1,2])
C0037047 (UMLS CUI [1,3])
C0679823 (UMLS CUI [1,2])
C0037047 (UMLS CUI [1,3])
*Inclusion criteria for siblings/spouses/offspring* Men or women aged 18-60 years for siblings or aged =16 years for offspringElig.phs001217.v3.p1.5
Item
*Inclusion criteria for siblings/spouses/offspring* Men or women aged 18-60 years for siblings or aged =16 years for offspring
boolean
C1512693 (UMLS CUI [1,1])
C0680063 (UMLS CUI [1,2])
C0037047 (UMLS CUI [1,3])
C0162409 (UMLS CUI [1,4])
C0001779 (UMLS CUI [1,5])
C0680063 (UMLS CUI [1,2])
C0037047 (UMLS CUI [1,3])
C0162409 (UMLS CUI [1,4])
C0001779 (UMLS CUI [1,5])
Living in the same village with proband
Item
Living in the same village with proband
boolean
C0237096 (UMLS CUI [1,1])
C0445247 (UMLS CUI [1,2])
C0562518 (UMLS CUI [1,3])
C0445247 (UMLS CUI [1,2])
C0562518 (UMLS CUI [1,3])
*Exclusion criteria for probands/siblings/spouses/offspring* Current stage-2 hypertension (systolic BP =160mm Hg and/or diastolic BP =100mm Hg)
Item
*Exclusion criteria for probands/siblings/spouses/offspring* Current stage-2 hypertension (systolic BP =160mm Hg and/or diastolic BP =100mm Hg)
boolean
C0680251 (UMLS CUI [1,1])
C0680063 (UMLS CUI [1,2])
C0162409 (UMLS CUI [1,3])
C0037047 (UMLS CUI [1,4])
C1948021 (UMLS CUI [1,5])
C5231205 (UMLS CUI [1,6])
C0680063 (UMLS CUI [1,2])
C0162409 (UMLS CUI [1,3])
C0037047 (UMLS CUI [1,4])
C1948021 (UMLS CUI [1,5])
C5231205 (UMLS CUI [1,6])
Current or recent (less than 1 month before screening visit) use of antihypertensive medications or medications that affect BP
Item
Current or recent (less than 1 month before screening visit) use of antihypertensive medications or medications that affect BP
boolean
C0521116 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C0240320 (UMLS CUI [1,3])
C0003364 (UMLS CUI [1,4])
C0013227 (UMLS CUI [1,5])
C0392760 (UMLS CUI [1,6])
C0005823 (UMLS CUI [1,7])
C0332185 (UMLS CUI [1,2])
C0240320 (UMLS CUI [1,3])
C0003364 (UMLS CUI [1,4])
C0013227 (UMLS CUI [1,5])
C0392760 (UMLS CUI [1,6])
C0005823 (UMLS CUI [1,7])
Secondary hypertension
Item
Secondary hypertension
boolean
C0155616 (UMLS CUI [1,1])
History of clinical cardiovascular disease, including myocardial infarction, congestive heart failure, stroke and peripheral arterial disease
Item
History of clinical cardiovascular disease, including myocardial infarction, congestive heart failure, stroke and peripheral arterial disease
boolean
C0455539 (UMLS CUI [1,1])
C0018802 (UMLS CUI [1,2])
C0027051 (UMLS CUI [1,3])
C1704436 (UMLS CUI [1,4])
C0038454 (UMLS CUI [1,5])
C0018802 (UMLS CUI [1,2])
C0027051 (UMLS CUI [1,3])
C1704436 (UMLS CUI [1,4])
C0038454 (UMLS CUI [1,5])
Chronic kidney failure or urinary albumin concentration =20 mg/dl
Item
Chronic kidney failure or urinary albumin concentration =20 mg/dl
boolean
C0022661 (UMLS CUI [1,1])
C3835016 (UMLS CUI [1,2])
C3835016 (UMLS CUI [1,2])
Current diabetes (fasting serum glucose =126 mg/dl) or use of insulin or oral hypoglycaemic agents
Item
Current diabetes (fasting serum glucose =126 mg/dl) or use of insulin or oral hypoglycaemic agents
boolean
C0521116 (UMLS CUI [1,1])
C0011849 (UMLS CUI [1,2])
C0240016 (UMLS CUI [1,3])
C1875585 (UMLS CUI [1,4])
C0011849 (UMLS CUI [1,2])
C0240016 (UMLS CUI [1,3])
C1875585 (UMLS CUI [1,4])
Peptic ulcer disease requiring treatment during the previous 2 years
Item
Peptic ulcer disease requiring treatment during the previous 2 years
boolean
C0030920 (UMLS CUI [1,1])
C0815189 (UMLS CUI [1,2])
C0815189 (UMLS CUI [1,2])
Liver disease requiring treatment during the previous 2 years
Item
Liver disease requiring treatment during the previous 2 years
boolean
C0023895 (UMLS CUI [1,1])
C0815189 (UMLS CUI [1,2])
C0815189 (UMLS CUI [1,2])
Currently pregnant women
Item
Currently pregnant women
boolean
C0032961 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])
C0521116 (UMLS CUI [1,2])
Heavy alcohol drinkers (more than 14 drinks per week)Elig.phs001217.v3.p1.16
Item
Heavy alcohol drinkers (more than 14 drinks per week)
boolean
C2030272 (UMLS CUI [1,1])
Currently adhering to a low-sodium diet
Item
Currently adhering to a low-sodium diet
boolean
C0521116 (UMLS CUI [1,1])
C0012169 (UMLS CUI [1,2])
C0012169 (UMLS CUI [1,2])
Inability or unwillingness to participate or sign informed consent form
Item
Inability or unwillingness to participate or sign informed consent form
boolean
C1299582 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C0679823 (UMLS CUI [1,3])
C0021430 (UMLS CUI [1,4])
C0558080 (UMLS CUI [1,2])
C0679823 (UMLS CUI [1,3])
C0021430 (UMLS CUI [1,4])