ID

45697

Beschreibung

Principal Investigator: Ulrike Peters, PhD, MPH, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; University of Washington, Seattle, WA, USA MeSH: Colorectal Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001315 *COLON, Colorectal Cancer: Longitudinal Observational study on Nutritional and lifestyle factors that influence colorectal tumor recurrence, survival and quality of life:* The COLON study is a multi-center prospective cohort study to assess the role of diet and other lifestyle factors in cancer recurrence and survival among incident colorectal cancer patients in the Netherlands. *DACHS, Darmkrebs: Chancen der Verhütung durch Screening:*This German study was initiated as a large population-based case-control study in 2003 in the Rhine-Neckar-Odenwald region (southwest region of Germany) to assess the potential of endoscopic screening for reduction of colorectal cancer risk and to investigate etiologic determinants of disease, particularly lifestyle/environmental factors and genetic factors. During an in-person interview, data were collected on demographics, medical history, family history of CRC, and various life-style factors, as were blood and mouthwash samples. *EPIC, European Prospective Investigation into Cancer:* EPIC is an on-going multicenter prospective cohort study designed to investigate the associations between diet, lifestyle, genetic and environmental factors and various types of cancer. *HPFS, Health Professionals Follow-up Study:* HPFS is a parallel prospective study to the NHS. The HPFS cohort comprised 51,529 men aged 40-75 who, in 1986, responded to a mailed questionnaire. Participants provided information on health related exposures, including current and past smoking history, age, weight, height, diet, physical activity, aspirin use, and family history of colorectal cancer. Colorectal cancer and other outcomes were reported by participants or next-of-kin and were followed up through review of the medical and pathology record by physicians. Overall, more than 97% of self-reported colorectal cancers were confirmed by medical record review. Information was abstracted on histology and primary location. Follow-up evaluation has been excellent, with 94% of the men responding to date. *NHS, Nurses' Health Study:* The NHS cohort began in 1976 when 121,700 married female registered nurses age 30-55 years returned the initial questionnaire that ascertained a variety of important health-related exposures [PMID:248266]. Since 1976, follow-up questionnaires have been mailed every 2 years. Colorectal cancer and other outcomes were reported by participants or next-of-kin and followed up through review of the medical and pathology record by physicians. Overall, more than 97% of self-reported colorectal cancers were confirmed by medical-record review. Information was abstracted on histology and primary location. The rate of follow-up evaluation has been high: as a proportion of the total possible follow-up time, follow-up evaluation has been more than 92%. *NQplus, Nutrition Questionnaires plus:* NQplus is a longitudinal observational study on diet and health in the general Dutch population.

Link

dbGaP-study=phs001315

Stichworte

Versionen (1)
  1. 10.05.23 10.05.23 - Chiara Middel
Rechteinhaber

Ulrike Peters, PhD, MPH, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; University of Washington, Seattle, WA, USA

Hochgeladen am

10. Mai 2023

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs001315 GECCO: Detecting Common and Rare Genetic Loci and GxE Interactions in Colorectal Cancer

Englisch

Eligibility Criteria

5 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*COLON, Colorectal Cancer: Longitudinal Observational study on Nutritional and lifestyle factors that influence colorectal tumor recurrence, survival and quality of life: *Patients with colorectal cancer from 11 hospitals were invited upon diagnosis. Patients with a history of colorectal cancer or (partial) bowel resection, chronic inflammatory bowel disease, hereditary colorectal cancer syndromes, or dementia were excluded from the study. At diagnosis and at several time points during follow-up, patients donated a blood sample and filled out questionnaires about diet and other lifestyle factors. Blood samples are stored in a biobank to facilitate future analyses. Information on vital status is retrieved by linkage with national registries. Information on clinical characteristics is gathered from linkage with the Netherlands Cancer Registry and with hospital databases. A total of 743 colorectal cancer samples were selected for genotyping. Matching controls were selected from the NQplus study described below.
Beschreibung

Elig.phs001315.v1.p1.1

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0242800
UMLS CUI [1,2]
C0011900
UMLS CUI [1,3]
C0009402
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0262926
UMLS CUI [2,3]
C0009402
UMLS CUI [2,4]
C0741614
UMLS CUI [2,5]
C0021390
UMLS CUI [2,6]
C0009402
UMLS CUI [2,7]
C0039082
UMLS CUI [2,8]
C0439660
UMLS CUI [2,9]
C0497327
UMLS CUI [3,1]
C0011008
UMLS CUI [3,2]
C0011900
UMLS CUI [3,3]
C0439547
UMLS CUI [3,4]
C1522577
UMLS CUI [3,5]
C1277698
UMLS CUI [3,6]
C3273494
UMLS CUI [3,7]
C0034394
UMLS CUI [4,1]
C0178913
UMLS CUI [4,2]
C1698986
UMLS CUI [4,3]
C0206512
UMLS CUI [5,1]
C1148433
UMLS CUI [5,2]
C1514918
UMLS CUI [5,3]
C0034975
UMLS CUI [5,4]
C0681788
UMLS CUI [6,1]
C1533716
UMLS CUI [6,2]
C0449440
UMLS CUI [6,3]
C1514918
UMLS CUI [6,4]
C0034975
UMLS CUI [6,5]
C0681788
UMLS CUI [6,6]
C0019994
UMLS CUI [6,7]
C0242356
UMLS CUI [7,1]
C1265611
UMLS CUI [7,2]
C0009402
UMLS CUI [7,3]
C0870078
UMLS CUI [7,4]
C1285573
UMLS CUI [8,1]
C1708943
UMLS CUI [8,2]
C0027361
UMLS CUI [8,3]
C0008976
*DACHS, Darmkrebs: Chancen der Verhütung durch Screening:* Cases with a first diagnosis of invasive colorectal cancer (International Classification of Diseases 10 codes C18-C20) who were at least 30 years of age (no upper age limit), German speaking, a resident in the study region, and mentally and physically able to participate in a one-hour interview, were recruited by their treating physicians either in the hospital a few days after surgery, or by mail after discharge from the hospital. Cases were confirmed based on histologic reports and hospital discharge letters following diagnosis of colorectal cancer. All hospitals treating colorectal cancer patients in the study region participated. Community-based controls were randomly selected from population registries, employing frequency matching with respect to age (5-year groups), sex, and county of residence. Controls with a history of colorectal cancer were excluded. Controls were contacted by mail and follow-up calls. In total 1268 cases and 634 matched controls were selected for genotyping.
Beschreibung

Elig.phs001315.v1.p1.2

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0205435
UMLS CUI [1,2]
C0011900
UMLS CUI [1,3]
C0677898
UMLS CUI [1,4]
C0009402
UMLS CUI [1,5]
C0001779
UMLS CUI [1,6]
C0017477
UMLS CUI [1,7]
C1145677
UMLS CUI [1,8]
C0205276
UMLS CUI [1,9]
C2347958
UMLS CUI [1,10]
C2825164
UMLS CUI [1,11]
C0085732
UMLS CUI [1,12]
C0679823
UMLS CUI [1,13]
C0021822
UMLS CUI [2,1]
C0242800
UMLS CUI [2,2]
C1710470
UMLS CUI [2,3]
C3489408
UMLS CUI [3,1]
C0242800
UMLS CUI [3,2]
C1710470
UMLS CUI [3,3]
C0231290
UMLS CUI [3,4]
C2361123
UMLS CUI [4,1]
C0011900
UMLS CUI [4,2]
C0750484
UMLS CUI [4,3]
C0679557
UMLS CUI [4,4]
C0552421
UMLS CUI [5,1]
C0679823
UMLS CUI [5,2]
C0019994
UMLS CUI [5,3]
C0087111
UMLS CUI [5,4]
C0009402
UMLS CUI [5,5]
C2825164
UMLS CUI [6,1]
C0009932
UMLS CUI [6,2]
C0034656
UMLS CUI [6,3]
C0242802
UMLS CUI [6,4]
C1549709
UMLS CUI [6,5]
C1708943
UMLS CUI [6,6]
C0001779
UMLS CUI [6,7]
C0079399
UMLS CUI [6,8]
C1562954
UMLS CUI [7,1]
C0680251
UMLS CUI [7,2]
C0009932
UMLS CUI [7,3]
C0262926
UMLS CUI [7,4]
C0009402
UMLS CUI [8,1]
C0009932
UMLS CUI [8,2]
C0332158
UMLS CUI [8,3]
C0681850
UMLS CUI [8,4]
C0013849
UMLS CUI [8,5]
C1522577
UMLS CUI [8,6]
C0175745
UMLS CUI [9,1]
C1265611
UMLS CUI [9,2]
C0009932
UMLS CUI [9,3]
C1285573
*EPIC, European Prospective Investigation into Cancer:* In summary, 521,448 participants (~70% women) mostly aged 35 years or above were recruited between 1992 and 2000. Participants were recruited from 23 study centers in ten European countries. The current study included participants from France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, and United Kingdom (UK). Blood samples were collected at baseline according to standardized procedures, and stored at the International Agency for Research on Cancer (IARC; -196ºC, liquid nitrogen) for all countries except Sweden (-80ºC freezers). All study participants provided written informed consent. Ethical approval for the EPIC study was obtained from the review boards of IARC and local participating centers. Incident cancer cases were identified using population cancer registries in Italy, the Netherlands, Spain, and the United Kingdom. In France, Germany and Greece cancer cases were identified during follow-up by a combination of methods including: health insurance records, cancer and pathology registries, and by active follow-up directly through study participants or through next-of-kin. Controls were selected from the full cohort of individuals who were alive and free of cancer (except non-melanoma skin cancer) at the time of diagnoses of the cases, using incidence density sampling and matched by: age (±6 months at recruitment), sex, study center, follow-up time since blood collection, time of day at blood collection (±4 hours), fasting status, menopausal status, and phase of menstrual cycle at blood collection. The current study selected 2,400 incident colorectal cancer cases, and 2,400 matched controls.
Beschreibung

Elig.phs001315.v1.p1.3

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0242800
UMLS CUI [1,2]
C0449238
UMLS CUI [1,3]
C0001779
UMLS CUI [2,1]
C0242800
UMLS CUI [2,2]
C2825164
UMLS CUI [2,3]
C0015176
UMLS CUI [3,1]
C1997894
UMLS CUI [3,2]
C0079946
UMLS CUI [4,1]
C0005834
UMLS CUI [4,2]
C1442488
UMLS CUI [4,3]
C1698986
UMLS CUI [4,4]
C0260055
UMLS CUI [5,1]
C2347026
UMLS CUI [5,2]
C0038995
UMLS CUI [5,3]
C1698986
UMLS CUI [5,4]
C0175738
UMLS CUI [6,1]
C0742766
UMLS CUI [6,2]
C0021430
UMLS CUI [7,1]
C0086911
UMLS CUI [7,2]
C0205540
UMLS CUI [7,3]
C2825164
UMLS CUI [8,1]
C1551358
UMLS CUI [8,2]
C0006826
UMLS CUI [8,3]
C1706256
UMLS CUI [8,4]
C0600091
UMLS CUI [8,5]
C1257890
UMLS CUI [8,6]
C0805443
UMLS CUI [8,7]
C0022277
UMLS CUI [8,8]
C0027778
UMLS CUI [8,9]
C0037747
UMLS CUI [8,10]
C0041700
UMLS CUI [9,1]
C1706256
UMLS CUI [9,2]
C0600091
UMLS CUI [9,3]
C0017480
UMLS CUI [9,4]
C0016674
UMLS CUI [9,5]
C0018226
UMLS CUI [9,6]
C1522577
UMLS CUI [9,7]
C0021682
UMLS CUI [9,8]
C0805443
UMLS CUI [9,9]
C0034869
UMLS CUI [10,1]
C0242800
UMLS CUI [10,2]
C0009932
UMLS CUI [10,3]
C2584946
UMLS CUI [10,4]
C1298908
UMLS CUI [10,5]
C0006826
UMLS CUI [10,6]
C1705847
UMLS CUI [10,7]
C0699893
UMLS CUI [10,8]
C0021149
UMLS CUI [10,9]
C0178587
UMLS CUI [10,10]
C0870078
UMLS CUI [10,11]
C1708943
UMLS CUI [10,12]
C0027361
UMLS CUI [10,13]
C0001779
UMLS CUI [10,14]
C0079399
UMLS CUI [10,15]
C2825164
UMLS CUI [10,16]
C1522577
UMLS CUI [10,17]
C0439548
UMLS CUI [10,18]
C0015663
UMLS CUI [10,19]
C3829127
UMLS CUI [10,20]
C1818633
*HPFS, Health Professionals Follow-up Study:* In 1993-1995, 18,825 men in the HPFS mailed blood samples by overnight courier, which were aliquoted into buffy coat and stored in liquid nitrogen. In 2001-2004, 13,956 men in the HPFS who had not provided a blood sample previously, mailed in a swish-and-spit sample of buccal cells. Incident cases were defined as those occurring after the subject provided a blood or buccal sample. Prevalent cases were defined as those occurring after enrollment in the study in 1986, but before the subject provided either a blood or buccal sample. After excluding participants with histories of cancer (except non-melanoma skin cancer), ulcerative colitis, or familial polyposis, 2 case-control sets were constructed from which DNA was isolated from either buffy coat or buccal cells for genotyping, as follows: (1) a case-control set with cases of colorectal cancer matched to randomly selected controls who provided a blood sample and were free of colorectal cancer at the same time the colorectal cancer was diagnosed in the cases; and (2) a case-control set with cases of colorectal cancer matched to randomly selected controls who provided a buccal sample and were free of colorectal cancer at the same time the colorectal cancer was diagnosed in the case. For both case-control sets, matching criteria included year of birth (within 1 year) and month/year of blood or buccal cell sampling (within 6 months). Cases were pair-matched 1:1, 1:2, or 1:3 with a control participant(s). For this study, colorectal cancer cases were ascertained through January 1, 2010 and excluded cases included in the previous discovery GWAS of colorectal cancer [PMID:23266556]. If no control could be matched for a case using the initial stringent criteria, age criteria were relaxed to <5 years to find an eligible control. A total of 237 CRC cases and 236 controls were selected for genotyping.
Beschreibung

Elig.phs001315.v1.p1.4

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0449238
UMLS CUI [1,2]
C1997894
UMLS CUI [1,3]
C0024492
UMLS CUI [1,4]
C0178913
UMLS CUI [1,5]
C1510844
UMLS CUI [1,6]
C2347229
UMLS CUI [1,7]
C1698986
UMLS CUI [1,8]
C0260055
UMLS CUI [2,1]
C0449238
UMLS CUI [2,2]
C1997894
UMLS CUI [2,3]
C0024492
UMLS CUI [2,4]
C1554939
UMLS CUI [2,5]
C5419552
UMLS CUI [3,1]
C1551358
UMLS CUI [3,2]
C0868928
UMLS CUI [3,3]
C1704788
UMLS CUI [3,4]
C2745955
UMLS CUI [3,5]
C0231290
UMLS CUI [3,6]
C1999230
UMLS CUI [3,7]
C2347026
UMLS CUI [4,1]
C5204628
UMLS CUI [4,2]
C0868928
UMLS CUI [4,3]
C1704788
UMLS CUI [4,4]
C2745955
UMLS CUI [4,5]
C0231290
UMLS CUI [4,6]
C1516879
UMLS CUI [4,7]
C0332152
UMLS CUI [4,8]
C1999230
UMLS CUI [4,9]
C2347026
UMLS CUI [5,1]
C0680251
UMLS CUI [5,2]
C0262926
UMLS CUI [5,3]
C0006826
UMLS CUI [5,4]
C1705847
UMLS CUI [5,5]
C0699893
UMLS CUI [5,6]
C0009324
UMLS CUI [5,7]
C0241889
UMLS CUI [5,8]
C0032580
UMLS CUI [6,1]
C0009932
UMLS CUI [6,2]
C1698493
UMLS CUI [6,3]
C0150098
UMLS CUI [6,4]
C0009402
UMLS CUI [6,5]
C0034656
UMLS CUI [6,6]
C0332296
UMLS CUI [6,7]
C0006826
UMLS CUI [6,8]
C0011008
UMLS CUI [6,9]
C0011900
UMLS CUI [7,1]
C0009932
UMLS CUI [7,2]
C1698493
UMLS CUI [7,3]
C0150098
UMLS CUI [7,4]
C0009402
UMLS CUI [7,5]
C0034656
UMLS CUI [7,6]
C5419552
UMLS CUI [7,7]
C0332296
UMLS CUI [7,8]
C0006826
UMLS CUI [7,9]
C0011008
UMLS CUI [7,10]
C0011900
UMLS CUI [7,11]
C0009932
UMLS CUI [8,1]
C0009932
UMLS CUI [8,2]
C1698493
UMLS CUI [8,3]
C0150098
UMLS CUI [8,4]
C1708943
UMLS CUI [8,5]
C0243161
UMLS CUI [8,6]
C2826771
UMLS CUI [8,7]
C1302413
UMLS CUI [9,1]
C1698493
UMLS CUI [9,2]
C0009402
UMLS CUI [9,3]
C0680251
UMLS CUI [9,4]
C2348568
UMLS CUI [9,5]
C0205156
UMLS CUI [9,6]
C0008976
UMLS CUI [10,1]
C0009932
UMLS CUI [10,2]
C1298908
UMLS CUI [10,3]
C1708943
UMLS CUI [10,4]
C0243161
UMLS CUI [10,5]
C0542193
UMLS CUI [10,6]
C0001779
UMLS CUI [11,1]
C1698493
UMLS CUI [11,2]
C1265611
*NHS, Nurses' Health Study:*In 1989-1990, 32,826 women in NHS I mailed blood samples by overnight courier, which were aliquoted into buffy coat and stored in liquid nitrogen. In 2001-2004, 29,684 women in NHS I who did not previously provide a blood sample mailed a swish-and-spit sample of buccal cells. Incident cases were defined as those occurring after the subject provided a blood or buccal sample. Prevalent cases were defined as those occurring after enrollment in the study in 1976 but before the subject provided either a blood or buccal sample. After excluding participants with histories of cancer (except non-melanoma skin cancer), ulcerative colitis, or familial polyposis, 2 case-control sets were constructed from which DNA was isolated from either buffy coat or buccal cells for genotyping: (1) a case-control set with cases of colorectal cancer matched to randomly selected controls who provided a blood sample and were free of colorectal cancer at the same time the colorectal cancer was diagnosed in the case; and (2) a case-control set with cases of colorectal cancer matched to randomly selected controls who provided a buccal sample and were free of colorectal cancer at the same time the colorectal cancer was diagnosed in the cases. For this study, colorectal cancer cases were ascertained through June 1, 2012 and excluded cases included in the previous discovery GWAS of colorectal cancer [PMID:23266556]. For both case-control sets, matching criteria included year of birth (within 1 year) and month/year of blood or buccal cell sampling (within 1 year). If no control could be matched for a case using the initial stringent criteria, age criteria were relaxed to <5 years to find an eligible control. Cases were pair matched 1:1, 1:2, or 1:3 with a control participant(s). A total of 370 CRC cases and 370 controls were selected for genotyping.
Beschreibung

Elig.phs001315.v1.p1.5

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0043210
UMLS CUI [1,2]
C0024492
UMLS CUI [1,3]
C1277698
UMLS CUI [1,4]
C0439583
UMLS CUI [1,5]
C5237201
UMLS CUI [1,6]
C0200365
UMLS CUI [1,7]
C2347229
UMLS CUI [1,8]
C1698986
UMLS CUI [1,9]
C0260055
UMLS CUI [2,1]
C0043210
UMLS CUI [2,2]
C1298908
UMLS CUI [2,3]
C0205156
UMLS CUI [2,4]
C1277698
UMLS CUI [2,5]
C1554939
UMLS CUI [3,1]
C1551358
UMLS CUI [3,2]
C1698493
UMLS CUI [3,3]
C1704788
UMLS CUI [3,4]
C2745955
UMLS CUI [3,5]
C0231290
UMLS CUI [3,6]
C1302413
UMLS CUI [4,1]
C5204628
UMLS CUI [4,2]
C1698493
UMLS CUI [4,3]
C1704788
UMLS CUI [4,4]
C2745955
UMLS CUI [4,5]
C0231290
UMLS CUI [4,6]
C1516879
UMLS CUI [4,7]
C0332152
UMLS CUI [4,8]
C1302413
UMLS CUI [5,1]
C0680251
UMLS CUI [5,2]
C0455471
UMLS CUI [5,3]
C1705847
UMLS CUI [5,4]
C0007117
UMLS CUI [5,5]
C0553723
UMLS CUI [5,6]
C0009324
UMLS CUI [5,7]
C0241889
UMLS CUI [5,8]
C0032580
UMLS CUI [6,1]
C0872128
UMLS CUI [6,2]
C0012854
UMLS CUI [6,3]
C0205409
UMLS CUI [6,4]
C2936475
UMLS CUI [6,5]
C1578559
UMLS CUI [6,6]
C1285573
UMLS CUI [7,1]
C0872128
UMLS CUI [7,2]
C1698493
UMLS CUI [7,3]
C0009402
UMLS CUI [7,4]
C0150103
UMLS CUI [7,5]
C3898900
UMLS CUI [7,6]
C0679646
UMLS CUI [7,7]
C0178913
UMLS CUI [8,1]
C0872128
UMLS CUI [8,2]
C1698493
UMLS CUI [8,3]
C0009402
UMLS CUI [8,4]
C0150103
UMLS CUI [8,5]
C3898900
UMLS CUI [8,6]
C0679646
UMLS CUI [8,7]
C1578559
UMLS CUI [9,1]
C0680251
UMLS CUI [9,2]
C0205156
UMLS CUI [9,3]
C1880355
UMLS CUI [9,4]
C0009402
UMLS CUI [9,5]
C2350277
UMLS CUI [10,1]
C0150103
UMLS CUI [10,2]
C0243161
UMLS CUI [10,3]
C2826771
UMLS CUI [10,4]
C0011008
UMLS CUI [10,5]
C0200345
UMLS CUI [11,1]
C1698493
UMLS CUI [11,2]
C0150103
UMLS CUI [11,3]
C4743675
UMLS CUI [11,4]
C0035028
UMLS CUI [11,5]
C0001779
UMLS CUI [11,6]
C0243161
UMLS CUI [12,1]
C1265611
UMLS CUI [12,2]
C1285573
UMLS CUI [12,3]
C1698493
UMLS CUI [12,4]
C0009932
*NQplus, Nutrition Questionnaires plus:* A total of 2,048 participants were recruited by inviting randomly selected inhabitants of the neighboring cities Wageningen, Ede, Renkum and Arnhem. In Veenendaal, another neighboring city, one individual of each household was invited to participate in the NQplus study. Baseline measurements consisted of a fasting venipuncture, dietary assessment, a physical examination, 24-h urine collection and general and lifestyle questionnaires. For this study, 179 persons without a blood sample, and those with a history of colorectal cancer, chronic inflammatory bowel disease or dementia were excluded. From the remaining 1,869 NQplus participants, controls were selected, whom were matched to the colorectal cancer cases of the COLON study by age and gender. A total of 737 control samples were selected for genotyping.
Beschreibung

Elig.phs001315.v1.p1.6

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0679646
UMLS CUI [1,2]
C0242800
UMLS CUI [1,3]
C0439605
UMLS CUI [1,4]
C2826348
UMLS CUI [1,5]
C0237096
UMLS CUI [1,6]
C0017446
UMLS CUI [2,1]
C0205394
UMLS CUI [2,2]
C1555315
UMLS CUI [2,3]
C2826348
UMLS CUI [2,4]
C0205447
UMLS CUI [2,5]
C0237401
UMLS CUI [2,6]
C0020052
UMLS CUI [3,1]
C1442488
UMLS CUI [3,2]
C0242485
UMLS CUI [3,3]
C0015663
UMLS CUI [3,4]
C0600406
UMLS CUI [3,5]
C0814244
UMLS CUI [3,6]
C0031809
UMLS CUI [3,7]
C0455060
UMLS CUI [3,8]
C0332118
UMLS CUI [3,9]
C0023676
UMLS CUI [3,10]
C0034394
UMLS CUI [4,1]
C0680251
UMLS CUI [4,2]
C1298908
UMLS CUI [4,3]
C0470187
UMLS CUI [4,4]
C0178913
UMLS CUI [4,5]
C0009402
UMLS CUI [4,6]
C0021390
UMLS CUI [4,7]
C0497327
UMLS CUI [5,1]
C1708943
UMLS CUI [5,2]
C0009932
UMLS CUI [5,3]
C1698493
UMLS CUI [5,4]
C0009402
UMLS CUI [5,5]
C0079399
UMLS CUI [5,6]
C0001779
UMLS CUI [6,1]
C1265611
UMLS CUI [6,2]
C0009932
UMLS CUI [6,3]
C0370003
UMLS CUI [6,4]
C1285573
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Ähnliche Modelle

Eligibility Criteria

5 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001315.v1.p1.1
Item
*COLON, Colorectal Cancer: Longitudinal Observational study on Nutritional and lifestyle factors that influence colorectal tumor recurrence, survival and quality of life: *Patients with colorectal cancer from 11 hospitals were invited upon diagnosis. Patients with a history of colorectal cancer or (partial) bowel resection, chronic inflammatory bowel disease, hereditary colorectal cancer syndromes, or dementia were excluded from the study. At diagnosis and at several time points during follow-up, patients donated a blood sample and filled out questionnaires about diet and other lifestyle factors. Blood samples are stored in a biobank to facilitate future analyses. Information on vital status is retrieved by linkage with national registries. Information on clinical characteristics is gathered from linkage with the Netherlands Cancer Registry and with hospital databases. A total of 743 colorectal cancer samples were selected for genotyping. Matching controls were selected from the NQplus study described below.
boolean
C0242800 (UMLS CUI [1,1])
C0011900 (UMLS CUI [1,2])
C0009402 (UMLS CUI [1,3])
C0680251 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C0009402 (UMLS CUI [2,3])
C0741614 (UMLS CUI [2,4])
C0021390 (UMLS CUI [2,5])
C0009402 (UMLS CUI [2,6])
C0039082 (UMLS CUI [2,7])
C0439660 (UMLS CUI [2,8])
C0497327 (UMLS CUI [2,9])
C0011008 (UMLS CUI [3,1])
C0011900 (UMLS CUI [3,2])
C0439547 (UMLS CUI [3,3])
C1522577 (UMLS CUI [3,4])
C1277698 (UMLS CUI [3,5])
C3273494 (UMLS CUI [3,6])
C0034394 (UMLS CUI [3,7])
C0178913 (UMLS CUI [4,1])
C1698986 (UMLS CUI [4,2])
C0206512 (UMLS CUI [4,3])
C1148433 (UMLS CUI [5,1])
C1514918 (UMLS CUI [5,2])
C0034975 (UMLS CUI [5,3])
C0681788 (UMLS CUI [5,4])
C1533716 (UMLS CUI [6,1])
C0449440 (UMLS CUI [6,2])
C1514918 (UMLS CUI [6,3])
C0034975 (UMLS CUI [6,4])
C0681788 (UMLS CUI [6,5])
C0019994 (UMLS CUI [6,6])
C0242356 (UMLS CUI [6,7])
C1265611 (UMLS CUI [7,1])
C0009402 (UMLS CUI [7,2])
C0870078 (UMLS CUI [7,3])
C1285573 (UMLS CUI [7,4])
C1708943 (UMLS CUI [8,1])
C0027361 (UMLS CUI [8,2])
C0008976 (UMLS CUI [8,3])
Elig.phs001315.v1.p1.2
Item
*DACHS, Darmkrebs: Chancen der Verhütung durch Screening:* Cases with a first diagnosis of invasive colorectal cancer (International Classification of Diseases 10 codes C18-C20) who were at least 30 years of age (no upper age limit), German speaking, a resident in the study region, and mentally and physically able to participate in a one-hour interview, were recruited by their treating physicians either in the hospital a few days after surgery, or by mail after discharge from the hospital. Cases were confirmed based on histologic reports and hospital discharge letters following diagnosis of colorectal cancer. All hospitals treating colorectal cancer patients in the study region participated. Community-based controls were randomly selected from population registries, employing frequency matching with respect to age (5-year groups), sex, and county of residence. Controls with a history of colorectal cancer were excluded. Controls were contacted by mail and follow-up calls. In total 1268 cases and 634 matched controls were selected for genotyping.
boolean
C0205435 (UMLS CUI [1,1])
C0011900 (UMLS CUI [1,2])
C0677898 (UMLS CUI [1,3])
C0009402 (UMLS CUI [1,4])
C0001779 (UMLS CUI [1,5])
C0017477 (UMLS CUI [1,6])
C1145677 (UMLS CUI [1,7])
C0205276 (UMLS CUI [1,8])
C2347958 (UMLS CUI [1,9])
C2825164 (UMLS CUI [1,10])
C0085732 (UMLS CUI [1,11])
C0679823 (UMLS CUI [1,12])
C0021822 (UMLS CUI [1,13])
C0242800 (UMLS CUI [2,1])
C1710470 (UMLS CUI [2,2])
C3489408 (UMLS CUI [2,3])
C0242800 (UMLS CUI [3,1])
C1710470 (UMLS CUI [3,2])
C0231290 (UMLS CUI [3,3])
C2361123 (UMLS CUI [3,4])
C0011900 (UMLS CUI [4,1])
C0750484 (UMLS CUI [4,2])
C0679557 (UMLS CUI [4,3])
C0552421 (UMLS CUI [4,4])
C0679823 (UMLS CUI [5,1])
C0019994 (UMLS CUI [5,2])
C0087111 (UMLS CUI [5,3])
C0009402 (UMLS CUI [5,4])
C2825164 (UMLS CUI [5,5])
C0009932 (UMLS CUI [6,1])
C0034656 (UMLS CUI [6,2])
C0242802 (UMLS CUI [6,3])
C1549709 (UMLS CUI [6,4])
C1708943 (UMLS CUI [6,5])
C0001779 (UMLS CUI [6,6])
C0079399 (UMLS CUI [6,7])
C1562954 (UMLS CUI [6,8])
C0680251 (UMLS CUI [7,1])
C0009932 (UMLS CUI [7,2])
C0262926 (UMLS CUI [7,3])
C0009402 (UMLS CUI [7,4])
C0009932 (UMLS CUI [8,1])
C0332158 (UMLS CUI [8,2])
C0681850 (UMLS CUI [8,3])
C0013849 (UMLS CUI [8,4])
C1522577 (UMLS CUI [8,5])
C0175745 (UMLS CUI [8,6])
C1265611 (UMLS CUI [9,1])
C0009932 (UMLS CUI [9,2])
C1285573 (UMLS CUI [9,3])
Elig.phs001315.v1.p1.3
Item
*EPIC, European Prospective Investigation into Cancer:* In summary, 521,448 participants (~70% women) mostly aged 35 years or above were recruited between 1992 and 2000. Participants were recruited from 23 study centers in ten European countries. The current study included participants from France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, and United Kingdom (UK). Blood samples were collected at baseline according to standardized procedures, and stored at the International Agency for Research on Cancer (IARC; -196ºC, liquid nitrogen) for all countries except Sweden (-80ºC freezers). All study participants provided written informed consent. Ethical approval for the EPIC study was obtained from the review boards of IARC and local participating centers. Incident cancer cases were identified using population cancer registries in Italy, the Netherlands, Spain, and the United Kingdom. In France, Germany and Greece cancer cases were identified during follow-up by a combination of methods including: health insurance records, cancer and pathology registries, and by active follow-up directly through study participants or through next-of-kin. Controls were selected from the full cohort of individuals who were alive and free of cancer (except non-melanoma skin cancer) at the time of diagnoses of the cases, using incidence density sampling and matched by: age (±6 months at recruitment), sex, study center, follow-up time since blood collection, time of day at blood collection (±4 hours), fasting status, menopausal status, and phase of menstrual cycle at blood collection. The current study selected 2,400 incident colorectal cancer cases, and 2,400 matched controls.
boolean
C0242800 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0242800 (UMLS CUI [2,1])
C2825164 (UMLS CUI [2,2])
C0015176 (UMLS CUI [2,3])
C1997894 (UMLS CUI [3,1])
C0079946 (UMLS CUI [3,2])
C0005834 (UMLS CUI [4,1])
C1442488 (UMLS CUI [4,2])
C1698986 (UMLS CUI [4,3])
C0260055 (UMLS CUI [4,4])
C2347026 (UMLS CUI [5,1])
C0038995 (UMLS CUI [5,2])
C1698986 (UMLS CUI [5,3])
C0175738 (UMLS CUI [5,4])
C0742766 (UMLS CUI [6,1])
C0021430 (UMLS CUI [6,2])
C0086911 (UMLS CUI [7,1])
C0205540 (UMLS CUI [7,2])
C2825164 (UMLS CUI [7,3])
C1551358 (UMLS CUI [8,1])
C0006826 (UMLS CUI [8,2])
C1706256 (UMLS CUI [8,3])
C0600091 (UMLS CUI [8,4])
C1257890 (UMLS CUI [8,5])
C0805443 (UMLS CUI [8,6])
C0022277 (UMLS CUI [8,7])
C0027778 (UMLS CUI [8,8])
C0037747 (UMLS CUI [8,9])
C0041700 (UMLS CUI [8,10])
C1706256 (UMLS CUI [9,1])
C0600091 (UMLS CUI [9,2])
C0017480 (UMLS CUI [9,3])
C0016674 (UMLS CUI [9,4])
C0018226 (UMLS CUI [9,5])
C1522577 (UMLS CUI [9,6])
C0021682 (UMLS CUI [9,7])
C0805443 (UMLS CUI [9,8])
C0034869 (UMLS CUI [9,9])
C0242800 (UMLS CUI [10,1])
C0009932 (UMLS CUI [10,2])
C2584946 (UMLS CUI [10,3])
C1298908 (UMLS CUI [10,4])
C0006826 (UMLS CUI [10,5])
C1705847 (UMLS CUI [10,6])
C0699893 (UMLS CUI [10,7])
C0021149 (UMLS CUI [10,8])
C0178587 (UMLS CUI [10,9])
C0870078 (UMLS CUI [10,10])
C1708943 (UMLS CUI [10,11])
C0027361 (UMLS CUI [10,12])
C0001779 (UMLS CUI [10,13])
C0079399 (UMLS CUI [10,14])
C2825164 (UMLS CUI [10,15])
C1522577 (UMLS CUI [10,16])
C0439548 (UMLS CUI [10,17])
C0015663 (UMLS CUI [10,18])
C3829127 (UMLS CUI [10,19])
C1818633 (UMLS CUI [10,20])
Elig.phs001315.v1.p1.4
Item
*HPFS, Health Professionals Follow-up Study:* In 1993-1995, 18,825 men in the HPFS mailed blood samples by overnight courier, which were aliquoted into buffy coat and stored in liquid nitrogen. In 2001-2004, 13,956 men in the HPFS who had not provided a blood sample previously, mailed in a swish-and-spit sample of buccal cells. Incident cases were defined as those occurring after the subject provided a blood or buccal sample. Prevalent cases were defined as those occurring after enrollment in the study in 1986, but before the subject provided either a blood or buccal sample. After excluding participants with histories of cancer (except non-melanoma skin cancer), ulcerative colitis, or familial polyposis, 2 case-control sets were constructed from which DNA was isolated from either buffy coat or buccal cells for genotyping, as follows: (1) a case-control set with cases of colorectal cancer matched to randomly selected controls who provided a blood sample and were free of colorectal cancer at the same time the colorectal cancer was diagnosed in the cases; and (2) a case-control set with cases of colorectal cancer matched to randomly selected controls who provided a buccal sample and were free of colorectal cancer at the same time the colorectal cancer was diagnosed in the case. For both case-control sets, matching criteria included year of birth (within 1 year) and month/year of blood or buccal cell sampling (within 6 months). Cases were pair-matched 1:1, 1:2, or 1:3 with a control participant(s). For this study, colorectal cancer cases were ascertained through January 1, 2010 and excluded cases included in the previous discovery GWAS of colorectal cancer [PMID:23266556]. If no control could be matched for a case using the initial stringent criteria, age criteria were relaxed to <5 years to find an eligible control. A total of 237 CRC cases and 236 controls were selected for genotyping.
boolean
C0449238 (UMLS CUI [1,1])
C1997894 (UMLS CUI [1,2])
C0024492 (UMLS CUI [1,3])
C0178913 (UMLS CUI [1,4])
C1510844 (UMLS CUI [1,5])
C2347229 (UMLS CUI [1,6])
C1698986 (UMLS CUI [1,7])
C0260055 (UMLS CUI [1,8])
C0449238 (UMLS CUI [2,1])
C1997894 (UMLS CUI [2,2])
C0024492 (UMLS CUI [2,3])
C1554939 (UMLS CUI [2,4])
C5419552 (UMLS CUI [2,5])
C1551358 (UMLS CUI [3,1])
C0868928 (UMLS CUI [3,2])
C1704788 (UMLS CUI [3,3])
C2745955 (UMLS CUI [3,4])
C0231290 (UMLS CUI [3,5])
C1999230 (UMLS CUI [3,6])
C2347026 (UMLS CUI [3,7])
C5204628 (UMLS CUI [4,1])
C0868928 (UMLS CUI [4,2])
C1704788 (UMLS CUI [4,3])
C2745955 (UMLS CUI [4,4])
C0231290 (UMLS CUI [4,5])
C1516879 (UMLS CUI [4,6])
C0332152 (UMLS CUI [4,7])
C1999230 (UMLS CUI [4,8])
C2347026 (UMLS CUI [4,9])
C0680251 (UMLS CUI [5,1])
C0262926 (UMLS CUI [5,2])
C0006826 (UMLS CUI [5,3])
C1705847 (UMLS CUI [5,4])
C0699893 (UMLS CUI [5,5])
C0009324 (UMLS CUI [5,6])
C0241889 (UMLS CUI [5,7])
C0032580 (UMLS CUI [5,8])
C0009932 (UMLS CUI [6,1])
C1698493 (UMLS CUI [6,2])
C0150098 (UMLS CUI [6,3])
C0009402 (UMLS CUI [6,4])
C0034656 (UMLS CUI [6,5])
C0332296 (UMLS CUI [6,6])
C0006826 (UMLS CUI [6,7])
C0011008 (UMLS CUI [6,8])
C0011900 (UMLS CUI [6,9])
C0009932 (UMLS CUI [7,1])
C1698493 (UMLS CUI [7,2])
C0150098 (UMLS CUI [7,3])
C0009402 (UMLS CUI [7,4])
C0034656 (UMLS CUI [7,5])
C5419552 (UMLS CUI [7,6])
C0332296 (UMLS CUI [7,7])
C0006826 (UMLS CUI [7,8])
C0011008 (UMLS CUI [7,9])
C0011900 (UMLS CUI [7,10])
C0009932 (UMLS CUI [7,11])
C0009932 (UMLS CUI [8,1])
C1698493 (UMLS CUI [8,2])
C0150098 (UMLS CUI [8,3])
C1708943 (UMLS CUI [8,4])
C0243161 (UMLS CUI [8,5])
C2826771 (UMLS CUI [8,6])
C1302413 (UMLS CUI [8,7])
C1698493 (UMLS CUI [9,1])
C0009402 (UMLS CUI [9,2])
C0680251 (UMLS CUI [9,3])
C2348568 (UMLS CUI [9,4])
C0205156 (UMLS CUI [9,5])
C0008976 (UMLS CUI [9,6])
C0009932 (UMLS CUI [10,1])
C1298908 (UMLS CUI [10,2])
C1708943 (UMLS CUI [10,3])
C0243161 (UMLS CUI [10,4])
C0542193 (UMLS CUI [10,5])
C0001779 (UMLS CUI [10,6])
C1698493 (UMLS CUI [11,1])
C1265611 (UMLS CUI [11,2])
Elig.phs001315.v1.p1.5
Item
*NHS, Nurses' Health Study:*In 1989-1990, 32,826 women in NHS I mailed blood samples by overnight courier, which were aliquoted into buffy coat and stored in liquid nitrogen. In 2001-2004, 29,684 women in NHS I who did not previously provide a blood sample mailed a swish-and-spit sample of buccal cells. Incident cases were defined as those occurring after the subject provided a blood or buccal sample. Prevalent cases were defined as those occurring after enrollment in the study in 1976 but before the subject provided either a blood or buccal sample. After excluding participants with histories of cancer (except non-melanoma skin cancer), ulcerative colitis, or familial polyposis, 2 case-control sets were constructed from which DNA was isolated from either buffy coat or buccal cells for genotyping: (1) a case-control set with cases of colorectal cancer matched to randomly selected controls who provided a blood sample and were free of colorectal cancer at the same time the colorectal cancer was diagnosed in the case; and (2) a case-control set with cases of colorectal cancer matched to randomly selected controls who provided a buccal sample and were free of colorectal cancer at the same time the colorectal cancer was diagnosed in the cases. For this study, colorectal cancer cases were ascertained through June 1, 2012 and excluded cases included in the previous discovery GWAS of colorectal cancer [PMID:23266556]. For both case-control sets, matching criteria included year of birth (within 1 year) and month/year of blood or buccal cell sampling (within 1 year). If no control could be matched for a case using the initial stringent criteria, age criteria were relaxed to <5 years to find an eligible control. Cases were pair matched 1:1, 1:2, or 1:3 with a control participant(s). A total of 370 CRC cases and 370 controls were selected for genotyping.
boolean
C0043210 (UMLS CUI [1,1])
C0024492 (UMLS CUI [1,2])
C1277698 (UMLS CUI [1,3])
C0439583 (UMLS CUI [1,4])
C5237201 (UMLS CUI [1,5])
C0200365 (UMLS CUI [1,6])
C2347229 (UMLS CUI [1,7])
C1698986 (UMLS CUI [1,8])
C0260055 (UMLS CUI [1,9])
C0043210 (UMLS CUI [2,1])
C1298908 (UMLS CUI [2,2])
C0205156 (UMLS CUI [2,3])
C1277698 (UMLS CUI [2,4])
C1554939 (UMLS CUI [2,5])
C1551358 (UMLS CUI [3,1])
C1698493 (UMLS CUI [3,2])
C1704788 (UMLS CUI [3,3])
C2745955 (UMLS CUI [3,4])
C0231290 (UMLS CUI [3,5])
C1302413 (UMLS CUI [3,6])
C5204628 (UMLS CUI [4,1])
C1698493 (UMLS CUI [4,2])
C1704788 (UMLS CUI [4,3])
C2745955 (UMLS CUI [4,4])
C0231290 (UMLS CUI [4,5])
C1516879 (UMLS CUI [4,6])
C0332152 (UMLS CUI [4,7])
C1302413 (UMLS CUI [4,8])
C0680251 (UMLS CUI [5,1])
C0455471 (UMLS CUI [5,2])
C1705847 (UMLS CUI [5,3])
C0007117 (UMLS CUI [5,4])
C0553723 (UMLS CUI [5,5])
C0009324 (UMLS CUI [5,6])
C0241889 (UMLS CUI [5,7])
C0032580 (UMLS CUI [5,8])
C0872128 (UMLS CUI [6,1])
C0012854 (UMLS CUI [6,2])
C0205409 (UMLS CUI [6,3])
C2936475 (UMLS CUI [6,4])
C1578559 (UMLS CUI [6,5])
C1285573 (UMLS CUI [6,6])
C0872128 (UMLS CUI [7,1])
C1698493 (UMLS CUI [7,2])
C0009402 (UMLS CUI [7,3])
C0150103 (UMLS CUI [7,4])
C3898900 (UMLS CUI [7,5])
C0679646 (UMLS CUI [7,6])
C0178913 (UMLS CUI [7,7])
C0872128 (UMLS CUI [8,1])
C1698493 (UMLS CUI [8,2])
C0009402 (UMLS CUI [8,3])
C0150103 (UMLS CUI [8,4])
C3898900 (UMLS CUI [8,5])
C0679646 (UMLS CUI [8,6])
C1578559 (UMLS CUI [8,7])
C0680251 (UMLS CUI [9,1])
C0205156 (UMLS CUI [9,2])
C1880355 (UMLS CUI [9,3])
C0009402 (UMLS CUI [9,4])
C2350277 (UMLS CUI [9,5])
C0150103 (UMLS CUI [10,1])
C0243161 (UMLS CUI [10,2])
C2826771 (UMLS CUI [10,3])
C0011008 (UMLS CUI [10,4])
C0200345 (UMLS CUI [10,5])
C1698493 (UMLS CUI [11,1])
C0150103 (UMLS CUI [11,2])
C4743675 (UMLS CUI [11,3])
C0035028 (UMLS CUI [11,4])
C0001779 (UMLS CUI [11,5])
C0243161 (UMLS CUI [11,6])
C1265611 (UMLS CUI [12,1])
C1285573 (UMLS CUI [12,2])
C1698493 (UMLS CUI [12,3])
C0009932 (UMLS CUI [12,4])
Elig.phs001315.v1.p1.6
Item
*NQplus, Nutrition Questionnaires plus:* A total of 2,048 participants were recruited by inviting randomly selected inhabitants of the neighboring cities Wageningen, Ede, Renkum and Arnhem. In Veenendaal, another neighboring city, one individual of each household was invited to participate in the NQplus study. Baseline measurements consisted of a fasting venipuncture, dietary assessment, a physical examination, 24-h urine collection and general and lifestyle questionnaires. For this study, 179 persons without a blood sample, and those with a history of colorectal cancer, chronic inflammatory bowel disease or dementia were excluded. From the remaining 1,869 NQplus participants, controls were selected, whom were matched to the colorectal cancer cases of the COLON study by age and gender. A total of 737 control samples were selected for genotyping.
boolean
C0679646 (UMLS CUI [1,1])
C0242800 (UMLS CUI [1,2])
C0439605 (UMLS CUI [1,3])
C2826348 (UMLS CUI [1,4])
C0237096 (UMLS CUI [1,5])
C0017446 (UMLS CUI [1,6])
C0205394 (UMLS CUI [2,1])
C1555315 (UMLS CUI [2,2])
C2826348 (UMLS CUI [2,3])
C0205447 (UMLS CUI [2,4])
C0237401 (UMLS CUI [2,5])
C0020052 (UMLS CUI [2,6])
C1442488 (UMLS CUI [3,1])
C0242485 (UMLS CUI [3,2])
C0015663 (UMLS CUI [3,3])
C0600406 (UMLS CUI [3,4])
C0814244 (UMLS CUI [3,5])
C0031809 (UMLS CUI [3,6])
C0455060 (UMLS CUI [3,7])
C0332118 (UMLS CUI [3,8])
C0023676 (UMLS CUI [3,9])
C0034394 (UMLS CUI [3,10])
C0680251 (UMLS CUI [4,1])
C1298908 (UMLS CUI [4,2])
C0470187 (UMLS CUI [4,3])
C0178913 (UMLS CUI [4,4])
C0009402 (UMLS CUI [4,5])
C0021390 (UMLS CUI [4,6])
C0497327 (UMLS CUI [4,7])
C1708943 (UMLS CUI [5,1])
C0009932 (UMLS CUI [5,2])
C1698493 (UMLS CUI [5,3])
C0009402 (UMLS CUI [5,4])
C0079399 (UMLS CUI [5,5])
C0001779 (UMLS CUI [5,6])
C1265611 (UMLS CUI [6,1])
C0009932 (UMLS CUI [6,2])
C0370003 (UMLS CUI [6,3])
C1285573 (UMLS CUI [6,4])
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