ID
45687
Descripción
Principal Investigator: Herbert Lachman, Albert Einstein College of Medicine, New York, NY, USA MeSH: Opioid-Related Disorders,Substance-Related Disorders https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001266 Genome wide analysis for addiction susceptibility genes is an affected sibling pair linkage study using subjects who were patients in methadone replacement treatment programs (MMTP). Such patients are highly addicted to opioids and usually to other addicting substances as well. For entry into the programs, patients had to be at least 18 years of age and had to satisfy DSM-IV criteria for opioid dependence. Despite their common substance use disorder diagnosis, patients enrolled in MMTPs generally have a heterogeneous mix of co-morbid psychiatric disorders including anti-social personality disorder, major depression and anxiety disorders, and often satisfy DSM-IV criteria of substance use disorders other than opioid dependence. Genetic analysis was carried out using genotyping data obtained from a 10K SNP array, and non-parametric linkage was assessed using MERLIN. This resulted in the identification of a linkage peak on 14q that overlapped the NRXN3 gene (neurexin 3), which was previously identified as a potential candidate gene for addiction, and subsequently identified as a target gene in other addiction studies and autism. In version 2 of this study, a text file containing 7704 SNPs with large allele frequency discrepancy as compared to 1000 Genomes is included. Users have the option to exlude these 7704 SNPs.
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Versiones (1)
- 3/5/23 3/5/23 - Simon Heim
Titular de derechos de autor
Herbert Lachman, Albert Einstein College of Medicine, New York, NY, USA
Subido en
3 de mayo de 2023
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs001266 Genome-Wide Analysis for Addiction Susceptibility Genes
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table informs of subject ID, subject consent group, source repository in which subject originated, ID assigned to the subject by the source repository, and subject's case - control status for opioid dependence.
- This pedigree data table provides subject's family information including the mother and father of the subject. This pedigree table also informs of subject's sex.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This table also informs of the source repository in which the sample was obtained and the ID assigned to the sample by the source repository.
- This subject phenotypes data table provides information about the abuse and dependency status of the subject for: opioids, cocaine, alcohol, nicotine, cannabis, stimulants, sedatives, and 'other' drugs. It also informs of subject's age, sex, race, twin status, live/death status, and the diagnostic system used on the subject.
- This sample attributes data table informs of body site where sample was collected and sample analyte type.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This subject consent data table informs of subject ID, subject consent group, source repository in which subject originated, ID assigned to the subject by the source repository, and subject's case - control status for opioid dependence.
- This pedigree data table provides subject's family information including the mother and father of the subject. This pedigree table also informs of subject's sex.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. This table also informs of the source repository in which the sample was obtained and the ID assigned to the sample by the source repository.
- This subject phenotypes data table provides information about the abuse and dependency status of the subject for: opioids, cocaine, alcohol, nicotine, cannabis, stimulants, sedatives, and 'other' drugs. It also informs of subject's age, sex, race, twin status, live/death status, and the diagnostic system used on the subject.
- This sample attributes data table informs of body site where sample was collected and sample analyte type.
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