ID

45681

Beschreibung

Principal Investigator: Nathan O. Stitziel, MD, PhD, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA MeSH: Coronary Artery Disease https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001227 The genetic basis of coronary artery disease in individuals of non-European ancestry is largely unknown. The Washington University Coronary Artery Disease Study (WUCADS) recruited participants of non-European ancestry with and without coronary artery disease to address this question. Whole genome sequencing in WUCADS was performed at the McDonnell Genome Institute at Washington University.

Link

dbGaP study = phs001227

Stichworte

Versionen (1)
  1. 26.04.23 26.04.23 - Simon Heim
Rechteinhaber

Nathan O. Stitziel, MD, PhD, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

Hochgeladen am

26. April 2023

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs001227 Washington University Coronary Artery Disease Study

Englisch

Eligibility Criteria

5 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Inclusion/Exclusion criteria:* We recruited WUCADS participants from the BJC HealthCare network. Subjects were eligible to participate as a case if they were of self-identified non-European ancestry and had a history of significant coronary artery disease defined as myocardial infarction, coronary revascularization, or stenosis ≥ 50% in a major epicardial coronary artery. To enrich cases for those most likely to be influenced by genetic factors, we preferentially focused on individuals who were diagnosed with significant coronary artery disease at or before the age of 60 and 70 for men and women, respectively. Subjects were eligible to participate as a control if they were of self-identified non-European ancestry and did not have a history of significant coronary artery disease defined above.
Beschreibung

*Inclusion/Exclusion criteria:* We recruited WUCADS participants from the BJC HealthCare network. Subjects were eligible to participate as a case if they were of self-identified non-European ancestry and had a history of significant coronary artery disease defined as myocardial infarction, coronary revascularization, or stenosis ≥ 50% in a major epicardial coronary artery. To enrich cases for those most likely to be influenced by genetic factors, we preferentially focused on individuals who were diagnosed with significant coronary artery disease at or before the age of 60 and 70 for men and women, respectively. Subjects were eligible to participate as a control if they were of self-identified non-European ancestry and did not have a history of significant coronary artery disease defined above.

Datentyp

boolean

Alias
UMLS CUI [1,1]
C2827031
UMLS CUI [1,2]
C2985691
UMLS CUI [2,1]
C0085973
UMLS CUI [2,2]
C5447420
UMLS CUI [2,3]
C1518422
UMLS CUI [2,4]
C0239307
UMLS CUI [2,5]
C0262926
UMLS CUI [2,6]
C1956346
UMLS CUI [2,7]
C0027051
UMLS CUI [2,8]
C0877341
UMLS CUI [2,9]
C0242231
UMLS CUI [3,1]
C0085973
UMLS CUI [3,2]
C0750501
UMLS CUI [3,3]
C1658408
UMLS CUI [3,4]
C0206132
UMLS CUI [4,1]
C4553389
UMLS CUI [4,2]
C1518422
UMLS CUI [4,3]
C0239307
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Ähnliche Modelle

Eligibility Criteria

5 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
*Inclusion/Exclusion criteria:* We recruited WUCADS participants from the BJC HealthCare network. Subjects were eligible to participate as a case if they were of self-identified non-European ancestry and had a history of significant coronary artery disease defined as myocardial infarction, coronary revascularization, or stenosis ≥ 50% in a major epicardial coronary artery. To enrich cases for those most likely to be influenced by genetic factors, we preferentially focused on individuals who were diagnosed with significant coronary artery disease at or before the age of 60 and 70 for men and women, respectively. Subjects were eligible to participate as a control if they were of self-identified non-European ancestry and did not have a history of significant coronary artery disease defined above.
Item
*Inclusion/Exclusion criteria:* We recruited WUCADS participants from the BJC HealthCare network. Subjects were eligible to participate as a case if they were of self-identified non-European ancestry and had a history of significant coronary artery disease defined as myocardial infarction, coronary revascularization, or stenosis ≥ 50% in a major epicardial coronary artery. To enrich cases for those most likely to be influenced by genetic factors, we preferentially focused on individuals who were diagnosed with significant coronary artery disease at or before the age of 60 and 70 for men and women, respectively. Subjects were eligible to participate as a control if they were of self-identified non-European ancestry and did not have a history of significant coronary artery disease defined above.
boolean
C2827031 (UMLS CUI [1,1])
C2985691 (UMLS CUI [1,2])
C0085973 (UMLS CUI [2,1])
C5447420 (UMLS CUI [2,2])
C1518422 (UMLS CUI [2,3])
C0239307 (UMLS CUI [2,4])
C0262926 (UMLS CUI [2,5])
C1956346 (UMLS CUI [2,6])
C0027051 (UMLS CUI [2,7])
C0877341 (UMLS CUI [2,8])
C0242231 (UMLS CUI [2,9])
C0085973 (UMLS CUI [3,1])
C0750501 (UMLS CUI [3,2])
C1658408 (UMLS CUI [3,3])
C0206132 (UMLS CUI [3,4])
C4553389 (UMLS CUI [4,1])
C1518422 (UMLS CUI [4,2])
C0239307 (UMLS CUI [4,3])
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