0 Ratings
ID

45681

Description

Principal Investigator: Nathan O. Stitziel, MD, PhD, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA MeSH: Coronary Artery Disease https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001227 The genetic basis of coronary artery disease in individuals of non-European ancestry is largely unknown. The Washington University Coronary Artery Disease Study (WUCADS) recruited participants of non-European ancestry with and without coronary artery disease to address this question. Whole genome sequencing in WUCADS was performed at the McDonnell Genome Institute at Washington University.

Link

dbGaP study = phs001227

Keywords

Versions (1)
  1. 4/26/23 4/26/23 - Simon Heim
Copyright Holder

Nathan O. Stitziel, MD, PhD, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

Uploaded on

April 26, 2023

DOI

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Creative Commons BY 4.0
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    dbGaP phs001227 Washington University Coronary Artery Disease Study

    English

    Eligibility Criteria

    5 forms  
    Inclusion and exclusion criteria
    Description

    Inclusion and exclusion criteria

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C0680251
    *Inclusion/Exclusion criteria:* We recruited WUCADS participants from the BJC HealthCare network. Subjects were eligible to participate as a case if they were of self-identified non-European ancestry and had a history of significant coronary artery disease defined as myocardial infarction, coronary revascularization, or stenosis ≥ 50% in a major epicardial coronary artery. To enrich cases for those most likely to be influenced by genetic factors, we preferentially focused on individuals who were diagnosed with significant coronary artery disease at or before the age of 60 and 70 for men and women, respectively. Subjects were eligible to participate as a control if they were of self-identified non-European ancestry and did not have a history of significant coronary artery disease defined above.
    Description

    *Inclusion/Exclusion criteria:* We recruited WUCADS participants from the BJC HealthCare network. Subjects were eligible to participate as a case if they were of self-identified non-European ancestry and had a history of significant coronary artery disease defined as myocardial infarction, coronary revascularization, or stenosis ≥ 50% in a major epicardial coronary artery. To enrich cases for those most likely to be influenced by genetic factors, we preferentially focused on individuals who were diagnosed with significant coronary artery disease at or before the age of 60 and 70 for men and women, respectively. Subjects were eligible to participate as a control if they were of self-identified non-European ancestry and did not have a history of significant coronary artery disease defined above.

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C2827031
    UMLS CUI [1,2]
    C2985691
    UMLS CUI [2,1]
    C0085973
    UMLS CUI [2,2]
    C5447420
    UMLS CUI [2,3]
    C1518422
    UMLS CUI [2,4]
    C0239307
    UMLS CUI [2,5]
    C0262926
    UMLS CUI [2,6]
    C1956346
    UMLS CUI [2,7]
    C0027051
    UMLS CUI [2,8]
    C0877341
    UMLS CUI [2,9]
    C0242231
    UMLS CUI [3,1]
    C0085973
    UMLS CUI [3,2]
    C0750501
    UMLS CUI [3,3]
    C1658408
    UMLS CUI [3,4]
    C0206132
    UMLS CUI [4,1]
    C4553389
    UMLS CUI [4,2]
    C1518422
    UMLS CUI [4,3]
    C0239307
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    Similar models

    Eligibility Criteria

    5 forms
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    Inclusion and exclusion criteria
    C1512693 (UMLS CUI [1,1])
    C0680251 (UMLS CUI [1,2])
    *Inclusion/Exclusion criteria:* We recruited WUCADS participants from the BJC HealthCare network. Subjects were eligible to participate as a case if they were of self-identified non-European ancestry and had a history of significant coronary artery disease defined as myocardial infarction, coronary revascularization, or stenosis ≥ 50% in a major epicardial coronary artery. To enrich cases for those most likely to be influenced by genetic factors, we preferentially focused on individuals who were diagnosed with significant coronary artery disease at or before the age of 60 and 70 for men and women, respectively. Subjects were eligible to participate as a control if they were of self-identified non-European ancestry and did not have a history of significant coronary artery disease defined above.
    Item
    *Inclusion/Exclusion criteria:* We recruited WUCADS participants from the BJC HealthCare network. Subjects were eligible to participate as a case if they were of self-identified non-European ancestry and had a history of significant coronary artery disease defined as myocardial infarction, coronary revascularization, or stenosis ≥ 50% in a major epicardial coronary artery. To enrich cases for those most likely to be influenced by genetic factors, we preferentially focused on individuals who were diagnosed with significant coronary artery disease at or before the age of 60 and 70 for men and women, respectively. Subjects were eligible to participate as a control if they were of self-identified non-European ancestry and did not have a history of significant coronary artery disease defined above.
    boolean
    C2827031 (UMLS CUI [1,1])
    C2985691 (UMLS CUI [1,2])
    C0085973 (UMLS CUI [2,1])
    C5447420 (UMLS CUI [2,2])
    C1518422 (UMLS CUI [2,3])
    C0239307 (UMLS CUI [2,4])
    C0262926 (UMLS CUI [2,5])
    C1956346 (UMLS CUI [2,6])
    C0027051 (UMLS CUI [2,7])
    C0877341 (UMLS CUI [2,8])
    C0242231 (UMLS CUI [2,9])
    C0085973 (UMLS CUI [3,1])
    C0750501 (UMLS CUI [3,2])
    C1658408 (UMLS CUI [3,3])
    C0206132 (UMLS CUI [3,4])
    C4553389 (UMLS CUI [4,1])
    C1518422 (UMLS CUI [4,2])
    C0239307 (UMLS CUI [4,3])
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