ID
45669
Descrição
Principal Investigator: Andy Futreal, PhD, UT MD Anderson Cancer Center, Houston, TX, USA MeSH: Melanoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001257 Antibody blockade of the inhibitory CTLA-4 pathway has led to clinical benefit in a subset of patients with metastatic melanoma. Anti-CTLA-4 enhances T cell responses, including production of IFN-γ, which is a critical cytokine for host immune responses. However, the role of IFN-γ signaling in tumor cells in the setting of anti-CTLA-4 therapy remains unknown. Here we demonstrate that, based upon exome sequencing data, patients identified as non-responders to anti-CTLA-4 (ipilimumab) harbor a much higher genomic defects in the IFN-γ pathway genes than melanoma patients who had clinical response to ipilimumab therapy.
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Versões (1)
- 02/04/2023 02/04/2023 - Simon Heim
Titular dos direitos
Andy Futreal, PhD, UT MD Anderson Cancer Center, Houston, TX, USA
Transferido a
2 de abril de 2023
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs001257 Genetic Analysis of Tumor Samples
The subject consent file includes subject IDs, consent information, subject aliases, and affection status of the subject for melanoma tumor.
- StudyEvent: SEV1
- The subject consent file includes subject IDs, consent information, subject aliases, and affection status of the subject for melanoma tumor.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample aliases and sample use.
- This subject phenotype table contains subject IDs, response upon anti-CTLA4 treatment or IFNgamma-stimulation, sex, and disease onset age.
- This sample attributes table contains sample IDs, sample type, analyte type, tumor status, histological type, tumor treatment, and name of the center which conducted sequencing.
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The subject consent file includes subject IDs, consent information, subject aliases, and affection status of the subject for melanoma tumor.
- StudyEvent: SEV1
- The subject consent file includes subject IDs, consent information, subject aliases, and affection status of the subject for melanoma tumor.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample aliases and sample use.
- This subject phenotype table contains subject IDs, response upon anti-CTLA4 treatment or IFNgamma-stimulation, sex, and disease onset age.
- This sample attributes table contains sample IDs, sample type, analyte type, tumor status, histological type, tumor treatment, and name of the center which conducted sequencing.
C0441833 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,2])
C0681850 (UMLS CUI [1,3])
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,3])