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ID
45658
Beschreibung
Principal Investigator: Neil E Caporaso, MD, National Institutes of Health, Bethesda, MD, USA MeSH: Waldenstrom Macroglobulinemia,Lymphoplasmacytoid Lymphoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001284 A discovery GWAS is performed, consisting of genotyping 221 Waldenstrom macroglobulinemia (WM) cases on the Illumina Omni Express 12v1.1 platform and analyzing the genotypes together with those of 3798 previously genotyped controls in a model taking into account gender, age, and principal components of ancestry (i.e., significant eigenvectors). Directly genotyped data are supplemented by imputation using the Haplotype Reference Consortium.
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- 23-03-23 23-03-23 - Simon Heim
Rechteinhaber
Neil E Caporaso, MD, National Institutes of Health, Bethesda, MD, USA
Hochgeladen am
23 maart 2023
DOI
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Creative Commons BY 4.0
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dbGaP phs001284 NCI Waldenstrom Macroglobulinemia Genome-wide Association Study
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, and case control status of the subject for Waldenstrom Macroglobulinemia or lymphoplasmacytic lymphoma.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, race, sex, age at diagnosis, and population structure principal components 1 and 2.
- This sample attributes table contains sample ID, histological type, body site, analyte type, and tumor status.
Ähnliche Modelle
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, and case control status of the subject for Waldenstrom Macroglobulinemia or lymphoplasmacytic lymphoma.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, race, sex, age at diagnosis, and population structure principal components 1 and 2.
- This sample attributes table contains sample ID, histological type, body site, analyte type, and tumor status.
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
*Inclusion criteria, Cases:* Individuals with a confirmed diagnosis of Waldenstrom Macroglobulinemia or lymphoplasmacytic lymphoma who provide informed consent for DNA collection, genetic studies and data-sharing.
Item
*Inclusion criteria, Cases:* Individuals with a confirmed diagnosis of Waldenstrom Macroglobulinemia or lymphoplasmacytic lymphoma who provide informed consent for DNA collection, genetic studies and data-sharing.
boolean
C1512693 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
C0750484 (UMLS CUI [1,4])
C0024419 (UMLS CUI [1,5])
C0334633 (UMLS CUI [1,6])
C0021430 (UMLS CUI [1,7])
C0012854 (UMLS CUI [1,8])
C0200345 (UMLS CUI [1,9])
C2827447 (UMLS CUI [1,10])
C2713450 (UMLS CUI [1,11])
C1706256 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
C0750484 (UMLS CUI [1,4])
C0024419 (UMLS CUI [1,5])
C0334633 (UMLS CUI [1,6])
C0021430 (UMLS CUI [1,7])
C0012854 (UMLS CUI [1,8])
C0200345 (UMLS CUI [1,9])
C2827447 (UMLS CUI [1,10])
C2713450 (UMLS CUI [1,11])
*Inclusion criteria, Controls:* Adults with no history of Waldenstrom macroglobulinemia, lymphoplasmacytic lymphoma, or other B-cell malignancy at enrollment who provide informed consent for DNA collection and genetic studies.
Item
*Inclusion criteria, Controls:* Adults with no history of Waldenstrom macroglobulinemia, lymphoplasmacytic lymphoma, or other B-cell malignancy at enrollment who provide informed consent for DNA collection and genetic studies.
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0001675 (UMLS CUI [1,3])
C0332122 (UMLS CUI [1,4])
C0024419 (UMLS CUI [1,5])
C0334633 (UMLS CUI [1,6])
C0079731 (UMLS CUI [1,7])
C0021430 (UMLS CUI [1,8])
C0012854 (UMLS CUI [1,9])
C0200345 (UMLS CUI [1,10])
C2827447 (UMLS CUI [1,11])
C0009932 (UMLS CUI [1,2])
C0001675 (UMLS CUI [1,3])
C0332122 (UMLS CUI [1,4])
C0024419 (UMLS CUI [1,5])
C0334633 (UMLS CUI [1,6])
C0079731 (UMLS CUI [1,7])
C0021430 (UMLS CUI [1,8])
C0012854 (UMLS CUI [1,9])
C0200345 (UMLS CUI [1,10])
C2827447 (UMLS CUI [1,11])
*Exclusion criteria:* 1) Diagnosis of monoclonal gammopathy of IgM type; 2) diagnosis of primary B-cell disorder other than Waldenstrom macroglobulinemia or lymphoplasmacytic lymphoma; 3) non-European ancestry
Item
*Exclusion criteria:* 1) Diagnosis of monoclonal gammopathy of IgM type; 2) diagnosis of primary B-cell disorder other than Waldenstrom macroglobulinemia or lymphoplasmacytic lymphoma; 3) non-European ancestry
boolean
C0680251 (UMLS CUI [1,1])
C0011900 (UMLS CUI [1,2])
C4288918 (UMLS CUI [1,3])
C5555430 (UMLS CUI [1,4])
C4723751 (UMLS CUI [1,5])
C0024419 (UMLS CUI [1,6])
C0334633 (UMLS CUI [1,7])
C1518422 (UMLS CUI [1,8])
C1257905 (UMLS CUI [1,9])
C0011900 (UMLS CUI [1,2])
C4288918 (UMLS CUI [1,3])
C5555430 (UMLS CUI [1,4])
C4723751 (UMLS CUI [1,5])
C0024419 (UMLS CUI [1,6])
C0334633 (UMLS CUI [1,7])
C1518422 (UMLS CUI [1,8])
C1257905 (UMLS CUI [1,9])
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