ID
45629
Descrizione
Principal Investigator: Kevin Eggan, PhD, Harvard University, Department of Stem Cell and Regenerative Medicine, Cambridge, MA, USA MeSH: Human Embryonic Stem Cells https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001343 Human embryonic stem cells (hESCs) are a powerful tool for the study of human development and can form the basis of cellular disease models or therapies. However, the genetic make-up and stability of hESCs has not been systematically studied at a genome-wide level with single nucleotide resolution. We therefore sequenced the whole exomes of widely available hESCs. The data generated has provided new insights about the nature of acquired variation and the genomic integrity of the cell lines. We anticipate that this online resource will enable investigators to access raw sequencing data in order to interrogate cell lines for different disease and trait-associated genetic variants.
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versioni (1)
- 02/03/23 02/03/23 - Simon Heim
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Kevin Eggan, PhD, Harvard University, Department of Stem Cell and Regenerative Medicine, Cambridge, MA, USA
Caricato su
2 marzo 2023
DOI
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Licenza
Creative Commons BY 4.0
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dbGaP phs001343 Biological Insights from the genome Sequences of Human Embryonic Stem Cell Lines
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