ID
45626
Descrição
Principal Investigator: S. Louis Bridges, Jr., MD, PhD, University of Alabama at Birmingham, Birmingham, AL, USA MeSH: Arthritis, Rheumatoid https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001360 The Consortium for the Longitudinal Evaluation of African-Americans with Early Rheumatoid Arthritis (*CLEAR*) Registry and Repository, supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (*NIAMS*), was established in 2000 to provide a resource for the scientific community to explore genetic and non-genetic factors affecting rheumatoid arthritis (*RA*) occurrence and outcomes in African Americans. The long term objective is a database and a repository of 1,100 RA and 550 matched healthy African-American subjects. This CLEAR Registry and Repository has two arms: a longitudinal arm for subjects with early RA (enrollment from 2000 to 2005) and a cross-sectional arm for subjects with any disease duration (enrollment from 2006 to 2012). CLEAR has two components: a database and a repository. The database contains extensive demographic, socioeconomic, clinical and radiographic (radiographs of hands and feet) information and bone mineral density data from DEXA scans. The repository contains genomic DNA, plasma and serum on most of the participants. Participants in CLEAR II had RNA isolated from peripheral blood cells.
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Versões (1)
- 28/02/2023 28/02/2023 - Simon Heim
Titular dos direitos
S. Louis Bridges, Jr., MD, PhD, University of Alabama at Birmingham, Birmingham, AL, USA
Transferido a
28 de fevereiro de 2023
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs001360 Genome-Wide Association Study in African-Americans with RA
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, subject source, and affection status of the subject for Rheumatoid Arthritis.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample source.
- This subject phenotype table contains subject IDs, sex, Rheumatoid Arthritis (RA) onset age, age at baseline, disease duration, height, weight, cyclic citrullinated peptide (CCP) and rheumatoid factor (RF) IgM status, smoking tobacco and drinking alcohol status, medication and steroid use history, and RA status.
- This sample attributes table contains sample ID, body site where sample was collected, analyte type, histological type, and name of the center which conducted genotyping.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, subject source, and affection status of the subject for Rheumatoid Arthritis.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample source.
- This subject phenotype table contains subject IDs, sex, Rheumatoid Arthritis (RA) onset age, age at baseline, disease duration, height, weight, cyclic citrullinated peptide (CCP) and rheumatoid factor (RF) IgM status, smoking tobacco and drinking alcohol status, medication and steroid use history, and RA status.
- This sample attributes table contains sample ID, body site where sample was collected, analyte type, histological type, and name of the center which conducted genotyping.
C0680251 (UMLS CUI [1,2])
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C0001779 (UMLS CUI [1,5])
C0017446 (UMLS CUI [1,6])
C0439069 (UMLS CUI [1,2])
C0085756 (UMLS CUI [1,2])
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C0150103 (UMLS CUI [1,2])
C0079399 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0017446 (UMLS CUI [1,5])
C0003873 (UMLS CUI [1,6])
C0409974 (UMLS CUI [1,7])
C4697009 (UMLS CUI [1,8])
C1134635 (UMLS CUI [1,9])