ID
45616
Descripción
Principal Investigator: Hanlee Ji, MD, Stanford University School of Medicine, Stanford, CA, USA MeSH: Stomach Neoplasms,Krukenberg Tumor https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001362 In this study, linked read sequencing was performed on two ovarian metastases and matched normal tissue, from a patient with primary diffuse gastric cancer. Linked read sequencing is a DNA preparation technology whereby high molecular weight molecules of DNA are uniquely barcoded prior to fragmentation and sequencing, thus retaining information about genomic contiguity. This study performed an extended analysis of linked read sequencing data to resolve the complex structures of structural variants in the cancer genomes. Complex structural rearrangements were identified in the genomic region surrounding the known oncogene FGFR2, and the association between FGFR2 and gastric cancer metastasis was demonstrated in an organoid model.
Link
Palabras clave
Versiones (1)
- 26/2/23 26/2/23 - Simon Heim
Titular de derechos de autor
Hanlee Ji, MD, Stanford University School of Medicine, Stanford, CA, USA
Subido en
26 de febrero de 2023
DOI
Para solicitar uno, por favor iniciar sesión.
Licencia
Creative Commons BY 4.0
Comentarios del modelo :
Puede comentar sobre el modelo de datos aquí. A través de las burbujas de diálogo en los grupos de elementos y elementos, puede agregar comentarios específicos.
Comentarios de grupo de elementos para :
Comentarios del elemento para :
Para descargar modelos de datos, debe haber iniciado sesión. Por favor iniciar sesión o Registrate gratis.
dbGaP phs001362 Linked Read Sequencing of Gastric Cancer Metastases
This subject phenotype table contains subject ID, sex, age of onset, and race.
- StudyEvent: SEV1
- The subject consent file includes subject IDs, consent information, and affection status of the subject for gastric cancer.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, sex, age of onset, and race.
- This sample attributes table contains sample ID, body site where tumor sample was collected, analyte type, tumor status, histological type, and primary tumor or metastasis.
Similar models
This subject phenotype table contains subject ID, sex, age of onset, and race.
- StudyEvent: SEV1
- The subject consent file includes subject IDs, consent information, and affection status of the subject for gastric cancer.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, sex, age of onset, and race.
- This sample attributes table contains sample ID, body site where tumor sample was collected, analyte type, tumor status, histological type, and primary tumor or metastasis.
C2348585 (UMLS CUI [1,2])