ID
45615
Beschreibung
Principal Investigator: MeSH: Health,Genetic Predisposition to Disease,Genome,Metabolome,Proteome,Microbiota https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001363 108 individuals (age 21-89+ years; 59% males, 41% females; 89% Caucasian; not recruited based on any specific phenotype) participated in an IRB-approved study from April 2014 to January 2015. Each individual had the genome sequenced in full. Blood was collected in clinics every three months. Additionally, participants completed at-home collections of saliva, stool, and first morning void urine every three months. Stool and saliva samples were shipped directly to the vendor by the participant, while urine was given back to the study coordinators for distribution to the proper sample vendor. For each successful participant in each round we carried out 218 clinical laboratory tests, measured up to 643 metabolites and 262 proteins, and measured the abundance of 4616 operational taxonomic units (OTUs) in the gut microbiome using 16S rRNA sequencing. The P100 study had four objectives: 1) Establish cost-efficient procedures for generating, storing and analyzing multiple sources of health data obtained over time from participants and analyzed in combination with genomic data; 2) Develop and deploy analytic tools for integrating these diverse datasets and deriving actionable information from their observed interrelationships; 3) Identify novel patterns within the streams of health data that indicate either wellness, or transitions between wellness and disease; 4) Learn how to best interface with and present longitudinal health information to individuals by studying the reactions and feedback from participants as they are presented actionable information.
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- 2/26/23 2/26/23 - Simon Heim
Rechteinhaber
dbGAP
Hochgeladen am
February 26, 2023
DOI
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Lizenz
Creative Commons BY 4.0
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dbGaP phs001363 The Pioneer 100 Wellness Project (P100)
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants with whole genome sequences and involved in the "The Pioneer 100 Wellness Project (P100)" project.
- Subject ID, sample ID, and sample use variable of participants with whole genome sequences and involved in the "The Pioneer 100 Wellness Project (P100)" project.
- Subject ID, age, race, and sex of participants with whole genome sequences and involved in the "The Pioneer 100 Wellness Project (P100)" project.
- Sample ID, analyte type, body site, genotyping center, histological type, tumor status of sample, and sequencing center of participants with whole genome sequences and involved in the "The Pioneer 100 Wellness Project (P100)" project.
- Subject ID, family ID, father, mother, twin ID, and gender of participants with whole genome sequence data and involved in the "Biesecker Lab (NHGRI) Whole Genome Medical Sequencing for Gene Discovery" project.
Ähnliche Modelle
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID and consent group of participants with whole genome sequences and involved in the "The Pioneer 100 Wellness Project (P100)" project.
- Subject ID, sample ID, and sample use variable of participants with whole genome sequences and involved in the "The Pioneer 100 Wellness Project (P100)" project.
- Subject ID, age, race, and sex of participants with whole genome sequences and involved in the "The Pioneer 100 Wellness Project (P100)" project.
- Sample ID, analyte type, body site, genotyping center, histological type, tumor status of sample, and sequencing center of participants with whole genome sequences and involved in the "The Pioneer 100 Wellness Project (P100)" project.
- Subject ID, family ID, father, mother, twin ID, and gender of participants with whole genome sequence data and involved in the "Biesecker Lab (NHGRI) Whole Genome Medical Sequencing for Gene Discovery" project.
C0680251 (UMLS CUI [1,2])
C0043038 (UMLS CUI [1,2])
C0006754 (UMLS CUI [1,3])
C0588387 (UMLS CUI [1,4])
C0086792 (UMLS CUI [1,5])
C0150775 (UMLS CUI [1,6])
C3812881 (UMLS CUI [1,7])
C0013849 (UMLS CUI [1,8])
C2826348 (UMLS CUI [1,9])
C5669842 (UMLS CUI [1,10])
C1450477 (UMLS CUI [1,11])
C1272753 (UMLS CUI [1,12])
C0811741 (UMLS CUI [1,13])
C0010992 (UMLS CUI [1,14])