ID

45611

Beschrijving

Principal Investigator: Glen J Weiss, MD, Cancer Treatment Centers of America, Goodyear, AZ, USA MeSH: Small Cell Lung Carcinoma https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001366 In this prospective study, custom genome-wide exome and whole transcriptome sequencing (NGS) was used to identify genomic events and associated expression changes in advanced Small Cell Lung Cancer (SCLC) and attempt to prescribe systemic therapy based on the results. Tumor/normal pairs were sequenced from 12 patients with advanced SCLC for this study.

Link

dbGaP-study=phs001366

Trefwoorden

  1. 22-02-23 22-02-23 - Chiara Middel
Houder van rechten

Glen J Weiss, MD, Cancer Treatment Centers of America, Goodyear, AZ, USA

Geüploaded op

22 februari 2023

DOI

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Licentie

Creative Commons BY 4.0

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dbGaP phs001366 Pilot Study of Exome and mRNA Profiling in Small Cell Lung Cancer Patients

Eligibility Criteria

Inclusion and exclusion criteria
Beschrijving

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
To participate, patients must have been age ≥18 and willing to undergo a fresh tumor biopsy. Other eligibility criteria included: Karnofsky performance status ≥70%, life expectancy <3 months, and baseline laboratory data indicating acceptable bone marrow reserve, liver, and renal function. Main exclusion criteria were symptomatic or untreated central nervous system (CNS) metastases, known active infections requiring intravenous antimicrobial therapy, pregnant or breast-feeding women, or tumor that was inaccessible for an adequate biopsy. Participation on another clinical trial involving treatment prior to or during participation on this study was allowed.
Beschrijving

Elig.phs001366.v1.p1.1

Datatype

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0001779
UMLS CUI [1,3]
C2586066
UMLS CUI [1,4]
C0027651
UMLS CUI [1,5]
C0005558
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C0206065
UMLS CUI [2,3]
C0023671
UMLS CUI [2,4]
C1442488
UMLS CUI [2,5]
C1254595
UMLS CUI [2,6]
C0205411
UMLS CUI [2,7]
C0005953
UMLS CUI [2,8]
C0232804
UMLS CUI [2,9]
C0232741
UMLS CUI [3,1]
C0680251
UMLS CUI [3,2]
C0231220
UMLS CUI [3,3]
C0332155
UMLS CUI [3,4]
C0220650
UMLS CUI [3,5]
C0205177
UMLS CUI [3,6]
C0009450
UMLS CUI [3,7]
C1514873
UMLS CUI [3,8]
C0338237
UMLS CUI [3,9]
C0205373
UMLS CUI [3,10]
C0032961
UMLS CUI [3,11]
C0006147
UMLS CUI [3,12]
C0027651
UMLS CUI [3,13]
C0005558
UMLS CUI [3,14]
C4743675
UMLS CUI [4,1]
C1298908
UMLS CUI [4,2]
C0680251
UMLS CUI [4,3]
C2348568
UMLS CUI [4,4]
C0008976

Similar models

Eligibility Criteria

Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001366.v1.p1.1
Item
To participate, patients must have been age ≥18 and willing to undergo a fresh tumor biopsy. Other eligibility criteria included: Karnofsky performance status ≥70%, life expectancy <3 months, and baseline laboratory data indicating acceptable bone marrow reserve, liver, and renal function. Main exclusion criteria were symptomatic or untreated central nervous system (CNS) metastases, known active infections requiring intravenous antimicrobial therapy, pregnant or breast-feeding women, or tumor that was inaccessible for an adequate biopsy. Participation on another clinical trial involving treatment prior to or during participation on this study was allowed.
boolean
C1512693 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C2586066 (UMLS CUI [1,3])
C0027651 (UMLS CUI [1,4])
C0005558 (UMLS CUI [1,5])
C1512693 (UMLS CUI [2,1])
C0206065 (UMLS CUI [2,2])
C0023671 (UMLS CUI [2,3])
C1442488 (UMLS CUI [2,4])
C1254595 (UMLS CUI [2,5])
C0205411 (UMLS CUI [2,6])
C0005953 (UMLS CUI [2,7])
C0232804 (UMLS CUI [2,8])
C0232741 (UMLS CUI [2,9])
C0680251 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
C0332155 (UMLS CUI [3,3])
C0220650 (UMLS CUI [3,4])
C0205177 (UMLS CUI [3,5])
C0009450 (UMLS CUI [3,6])
C1514873 (UMLS CUI [3,7])
C0338237 (UMLS CUI [3,8])
C0205373 (UMLS CUI [3,9])
C0032961 (UMLS CUI [3,10])
C0006147 (UMLS CUI [3,11])
C0027651 (UMLS CUI [3,12])
C0005558 (UMLS CUI [3,13])
C4743675 (UMLS CUI [3,14])
C1298908 (UMLS CUI [4,1])
C0680251 (UMLS CUI [4,2])
C2348568 (UMLS CUI [4,3])
C0008976 (UMLS CUI [4,4])

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